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  2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Cytochrome P450 NF-κB Interleukin Related
  4. Friedelin

Friedelin  (Synonyms: 軟木三萜酮)

目錄號: HY-N4110 純度: ≥99.0%
COA 產品使用指南 技術支持

Friedelin 源自 Maytenus ilicifolia(Mart) 的葉子。 Friedelin 是一種具有口服活性的 CYP3A4 非競爭性抑制劑，IC50 和 Ki 值分別為 10.79 μM 和 6.16 μM。 Friedelin 還是 CYP2E1 的競爭性抑制劑，IC50 和 Ki 值分別為 22.54 μM 和 18.02 μM。Friedelin 可用于炎癥、神經疾病以及代謝疾病領域的研究。

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Friedelin Chemical Structure

Friedelin Chemical Structure

CAS No. : 559-74-0

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規(guī)格 價格 是否有貨 數量
1 mg ￥1000
In-stock
5 mg ￥2600
In-stock
10 mg ￥3988
In-stock
25 mg 現(xiàn)貨 詢價
50 mg 現(xiàn)貨 詢價
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Customer Review

Other Forms of Friedelin:

MCE 顧客使用本產品發(fā)表的 1 篇科研文獻

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

Friedelin is derived from the leaves of Maytenus ilicifolia (Mart). Friedelin is an orally active non-competitive inhibitor of CYP3A4, with IC50 and Ki values of 10.79 μM and 6.16 μM, respectively. Friedelin is also a competitive inhibitor of CYP2E1, with IC50 and Ki values of 22.54 μM and 18.02 μM, respectively. Friedelin can be used in research related to inflammation, neurological diseases, and metabolic disorders[1][2][3][4].

IC50 & Target

CYP2

 

CYP3

 

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 GI50
11.1 μM
Compound: 4
Growth inhibition of human A549 cells by MTT assay
Growth inhibition of human A549 cells by MTT assay
[PMID: 20153184]
CHO EC50
> 10 μM
Compound: Friedeline
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
[PMID: 19911773]
COS-1 EC50
0 μM
Compound: Friedeline
Agonist activity at human FXR expressed in COS1 cells by luciferase reporter gene assay
Agonist activity at human FXR expressed in COS1 cells by luciferase reporter gene assay
[PMID: 19911773]
HepG2 2.2.15 CC50
1787.4 μM
Compound: C1; F
Cytotoxicity against human HepG2.215 cells assessed as reduction in cell viability after 3 days by MTT assay
Cytotoxicity against human HepG2.215 cells assessed as reduction in cell viability after 3 days by MTT assay
[PMID: 29627260]
HL-60 GI50
12.2 μM
Compound: 4
Growth inhibition of human HL60 cells by MTT assay
Growth inhibition of human HL60 cells by MTT assay
[PMID: 20153184]
HT-29 GI50
13.5 μM
Compound: 4
Growth inhibition of human HT-29 cells by MTT assay
Growth inhibition of human HT-29 cells by MTT assay
[PMID: 20153184]
MCF7 GI50
> 100 μM
Compound: 1
Cytotoxicity against human MCF7 cells by SRB assay
Cytotoxicity against human MCF7 cells by SRB assay
[PMID: 11678649]
NCI-H460 GI50
> 100 μM
Compound: 1
Cytotoxicity against human NCI-H460 cells by SRB assay
Cytotoxicity against human NCI-H460 cells by SRB assay
[PMID: 11678649]
SF-268 GI50
> 100 μM
Compound: 1
Cytotoxicity against human SF268 cells by SRB assay
Cytotoxicity against human SF268 cells by SRB assay
[PMID: 11678649]
SK-OV-3 GI50
12.7 μM
Compound: 4
Growth inhibition of human SKOV3 cells by MTT assay
Growth inhibition of human SKOV3 cells by MTT assay
[PMID: 20153184]
TK-10 GI50
> 100 μM
Compound: 1
Cytotoxicity against human TK10 cells by SRB assay
Cytotoxicity against human TK10 cells by SRB assay
[PMID: 11678649]
UACC-62 GI50
> 100 μM
Compound: 1
Cytotoxicity against human UACC62 cells by SRB assay
Cytotoxicity against human UACC62 cells by SRB assay
[PMID: 11678649]
體外研究
(In Vitro)

Friedelin (40 μM，24 小時) 可顯著抑制 NF-κB 通路的激活，并減少肌腱細胞中的炎癥反應[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[4]

Cell Line: Tenocytes (Tendinopathy)
Concentration: 40 μM
Incubation Time: 24 hours
Result: Significantly inhibited NF-κB pathway activation, reduced expression of inflammatory factors IL-1β, IL-6, and TNF-α.
體內研究
(In Vivo)

Friedelin (40 mg/kg，口服灌胃，一次性給藥) 在卡拉膠 (HY-125474) 誘導的急性炎癥 Wistar 大鼠模型中展現(xiàn)出強效抗炎活性[2]。
Friedelin (30 mg/kg，腹腔注射，每天一次，持續(xù) 14 天) 在東莨菪堿 (HY-N0296) 誘導的神經退行性疾病小鼠模型中可減輕神經功能障礙和記憶障礙[3]。
Friedelin (40 μM，局部注射至右側跟腱附近，每周一次，持續(xù) 4 周) 在 I 型膠原酶 (HY-E70005A) 誘導的肌腱病 C57BL/6 小鼠模型中可阻止肌腱病的進展[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Scopolamine (HY-N0296)-induced neurodegeneration mice model[3]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection (i.p.), once daily, for 14 days
Result: Improved scopolamine-induced oxidative stress, neurodegeneration, and memory impairment.
Animal Model: Carrageenan (HY-125474)-induced acute inflammation Wistar rats model[2]
Dosage: 40 mg/kg
Administration: Oral gavage (p.o.), single dose
Result: Maximally inhibited acute inflammatory response, significantly reduced paw edema thickness.
Animal Model: Collagenase Type I (HY-E70005A)-induced tendinopathy C57BL/6 mice model[4]
Dosage: 40 μM
Administration: Local injection near the right Achilles tendon, once weekly, for 4 weeks
Result: Significantly improved tendon mechanical strength, reduced inflammatory cell infiltration, restored ordered collagen fiber arrangement.
分子量

426.72

Formula

C30H50O
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

軟木三萜酮
結構分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性數據
細胞實驗： 

THF 中的溶解度 : 7.14 mg/mL (16.73 mM; 超聲助溶)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 2.3435 mL 11.7173 mL 23.4346 mL
5 mM 0.4687 mL 2.3435 mL 4.6869 mL
查看完整儲備液配制表

* 請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產品資料

純度: ≥99.0%

參考文獻

完整儲備液配制表

* 請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
THF 1 mM 2.3435 mL 11.7173 mL 23.4346 mL 58.5864 mL
5 mM 0.4687 mL 2.3435 mL 4.6869 mL 11.7173 mL
10 mM 0.2343 mL 1.1717 mL 2.3435 mL 5.8586 mL
15 mM 0.1562 mL 0.7812 mL 1.5623 mL 3.9058 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
Friedelin
目錄號：
HY-N4110
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