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  2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. β-Amyrenonol

β-Amyrenonol (11-Oxo-β-amyrin) 是一種甘草根中的齊墩果型三萜，是甘草次酸的前體。β-Amyrenonol 具有抗增殖和抗炎活性，并可作為合成許多三萜類化合物的骨架。

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β-Amyrenonol Chemical Structure

β-Amyrenonol Chemical Structure

CAS No. : 38242-02-3

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥2336
1 - 2 周
5 mg ￥5840
1 - 2 周
10 mg   詢價(jià)  
50 mg   詢價(jià)  

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

β-Amyrenonol (11-Oxo-β-amyrin), an oleanolic-type triterpenoid in licorice roots, is a precursor of Glycyrrhetinic acid. β-Amyrenonol has anti-proliferative and anti-inflammatory activities, and β-Amyrenonol could function as the skeleton for the synthesis of many triterpenoids[1][2].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
Sf21 IC50
> 40 μM
Compound: 4
Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis
Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis
[PMID: 31774676]
體外研究
(In Vitro)

β-Amyrenonol (11-Oxo-β-amyrin) inhibits cell growth of HL60 cells with an IC50 value of 26.3 μM[1].
β-Amyrenonol (11-Oxo-β-amyrin) (100 μM) significantly reduces lipopolysaccharide-induced TNFα release in THP-1 cells[1].
CYP88D6 is characterized by in vitro enzymatic activity assays and shown to catalyze the sequential two-step oxidation of β-amyrin at C-11 to produce β-Amyrenonol (11-Oxo-β-amyrin). CYP88D6 coexpressed with β-amyrin synthase in yeast also catalyzed in vivo oxidation of β-amyrin to β-Amyrenonol[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

440.70

Formula

C30H48O2
CAS 號(hào)
中文名稱

β-香樹脂酮醇
結(jié)構(gòu)分類
初始來源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

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產(chǎn)品名稱：
β-Amyrenonol
目錄號(hào)：
HY-N2920
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