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  2. Anti-infection
  3. Parasite
  4. α-Lapachone

α-Lapachone 具有殺錐蟲活性。

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α-Lapachone Chemical Structure

α-Lapachone Chemical Structure

CAS No. : 4707-33-9

1.  客戶無需承擔相應的運輸費用。

2.  同一機構（單位）同一產品試用裝僅限申領一次，同一機構（單位）一年內

     可免費申領三個不同產品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥361
In-stock
5 mg ￥800
In-stock
10 mg ￥1300
In-stock
25 mg ￥2600
In-stock
50 mg ￥4025
In-stock
100 mg ￥5738
In-stock
200 mg   詢價  
500 mg   詢價  

* Please select Quantity before adding items.

Customer Review

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

α-Lapachone shows trypanocidal activity[1].

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
A2780 GI50
4 μM
Compound: 29
Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay
[PMID: 20304655]
A549 IC50
> 30 μM
Compound: 4
Cytotoxicity against human A549 cells assessed as reduction in cell proliferation measured after 72 hrs by WST8 assay
Cytotoxicity against human A549 cells assessed as reduction in cell proliferation measured after 72 hrs by WST8 assay
[PMID: 32044231]
A549 GI50
16.3 μM
Compound: alpha-Lapachone
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 22819765]
A549 CC50
2.09 μM
Compound: 29
Cytotoxicity against human A549 cells incubated for 24 hrs by MTT assay
Cytotoxicity against human A549 cells incubated for 24 hrs by MTT assay
[PMID: 33333397]
BC1 cell line IC50
27.7 μM
Compound: 5
Cytotoxicity against human BC1 cells after 72 hrs by SRB assay
Cytotoxicity against human BC1 cells after 72 hrs by SRB assay
[PMID: 12088425]
Col2 IC50
40.9 μM
Compound: 5
Cytotoxicity against human Col2 cells after 72 hrs by SRB assay
Cytotoxicity against human Col2 cells after 72 hrs by SRB assay
[PMID: 12088425]
HBL-100 GI50
14 μM
Compound: 1a, alpha-lapachone
Growth inhibition of human HBL100 cells by SRB assay
Growth inhibition of human HBL100 cells by SRB assay
[PMID: 22560628]
HBL-100 GI50
14 μM
Compound: 29
Growth inhibition of human HBL100 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human HBL100 cells after 48 hrs by sulforhodamine B assay
[PMID: 20304655]
HCT-116 IC50
19.11 μM
Compound: alpha-Lapachone
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
10.1039/C4MD00371C
HeLa GI50
15 μM
Compound: 1a, alpha-lapachone
Growth inhibition of human HeLa cells by SRB assay
Growth inhibition of human HeLa cells by SRB assay
[PMID: 22560628]
HeLa GI50
15 μM
Compound: 29
Growth inhibition of human HeLa cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human HeLa cells after 48 hrs by sulforhodamine B assay
[PMID: 20304655]
HeLa GI50
25 μM
Compound: alpha-Lapachone
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 22819765]
HepG2 CC50
2.09 μM
Compound: 29
Cytotoxicity against human HepG2 cells incubated for 24 hrs by MTT assay
Cytotoxicity against human HepG2 cells incubated for 24 hrs by MTT assay
[PMID: 33333397]
HL-60 IC50
13.46 μM
Compound: 36
Cytotoxicity against human promyelocytic leukemia HL60 cell line by MTT assay
Cytotoxicity against human promyelocytic leukemia HL60 cell line by MTT assay
[PMID: 17249647]
HL-60 IC50
8.18 μM
Compound: alpha-Lapachone
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
10.1039/C4MD00371C
Hs 683 GI50
9 μM
Compound: alpha-Lapachone
Antiproliferative activity against human Hs683 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human Hs683 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 22819765]
J774.A1 IC50
285 μg/mL
Compound: 12a
Cytotoxicity against mouse J774.A1 cells measured after 24 hrs by resazurin based assay
Cytotoxicity against mouse J774.A1 cells measured after 24 hrs by resazurin based assay
[PMID: 31378595]
Jurkat GI50
75 μM
Compound: alpha-Lapachone
Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability after 48 hrs by MTT assay
Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 22819765]
K562 IC50
> 10 μM
Compound: 2
Antiproliferative activity against human K562 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human K562 cells measured after 48 hrs by MTT assay
[PMID: 30003778]
KB IC50
53.7 μM
Compound: 5
Cytotoxicity against human KB cells after 72 hrs by SRB assay
Cytotoxicity against human KB cells after 72 hrs by SRB assay
[PMID: 12088425]
KB-V1 IC50
34.3 μM
Compound: 5
Cytotoxicity against human KBV1 cells after 72 hrs by SRB assay
Cytotoxicity against human KBV1 cells after 72 hrs by SRB assay
[PMID: 12088425]
LLC-PK1 CC50
2.09 μM
Compound: 29
Cytotoxicity against human LLC-PK1 cells incubated for 24 hrs by MTT assay
Cytotoxicity against human LLC-PK1 cells incubated for 24 hrs by MTT assay
[PMID: 33333397]
LNCaP IC50
29.3 μM
Compound: 5
Cytotoxicity against human LNCAP cells after 72 hrs by SRB assay
Cytotoxicity against human LNCAP cells after 72 hrs by SRB assay
[PMID: 12088425]
LoVo GI50
24.4 μM
Compound: alpha-Lapachone
Antiproliferative activity against human LoVo cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human LoVo cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 22819765]
Lu1 IC50
21.9 μM
Compound: 5
Cytotoxicity against human Lu1 cells after 72 hrs by SRB assay
Cytotoxicity against human Lu1 cells after 72 hrs by SRB assay
[PMID: 12088425]
MCF7 IC50
> 30 μM
Compound: 4
Cytotoxicity against human MCF7 cells assessed as reduction in cell proliferation measured after 72 hrs by WST8 assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell proliferation measured after 72 hrs by WST8 assay
[PMID: 32044231]
MCF7 IC50
38 μM
Compound: 5
Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
[PMID: 12088425]
MDA-MB-231 IC50
> 10 μM
Compound: 2
Antiproliferative activity against human MDA-MB-231 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells measured after 48 hrs by MTT assay
[PMID: 30003778]
MDA-MB-231 IC50
> 30 μM
Compound: 4
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell proliferation measured after 72 hrs by WST8 assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell proliferation measured after 72 hrs by WST8 assay
[PMID: 32044231]
MRC5 IC50
> 100 μM
Compound: 15
Cytotoxicity against human MRC5 cells assessed as cell growth inhibition after 48 hrs by alamar blue assay
Cytotoxicity against human MRC5 cells assessed as cell growth inhibition after 48 hrs by alamar blue assay
[PMID: 26638044]
MRC5 CC50
2.09 μM
Compound: 29
Cytotoxicity against human MRC5 cells incubated for 24 hrs by MTT assay
Cytotoxicity against human MRC5 cells incubated for 24 hrs by MTT assay
[PMID: 33333397]
OVCAR-8 IC50
14.79 μM
Compound: alpha-Lapachone
Cytotoxicity against human OVCAR8 cells after 72 hrs by MTT assay
Cytotoxicity against human OVCAR8 cells after 72 hrs by MTT assay
10.1039/C4MD00371C
P388 IC50
0.8 μM
Compound: 5
Cytotoxicity against mouse P388 cells after 72 hrs by SRB assay
Cytotoxicity against mouse P388 cells after 72 hrs by SRB assay
[PMID: 12088425]
PBMC IC50
> 20.66 μM
Compound: alpha-Lapachone
Cytotoxicity against human PBMC cells after 72 hrs by MTT assay
Cytotoxicity against human PBMC cells after 72 hrs by MTT assay
10.1039/C4MD00371C
PC-3 GI50
13 μM
Compound: alpha-Lapachone
Antiproliferative activity against human PC3 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 22819765]
Peritoneal macrophage cell CC50
3.8 μM
Compound: 17
Cytotoxicity against Swiss mouse peritoneal macrophages after 24 hrs by MTT assay
Cytotoxicity against Swiss mouse peritoneal macrophages after 24 hrs by MTT assay
[PMID: 23535320]
SF-295 IC50
18.77 μM
Compound: alpha-Lapachone
Cytotoxicity against human SF295 cells after 72 hrs by MTT assay
Cytotoxicity against human SF295 cells after 72 hrs by MTT assay
10.1039/C4MD00371C
SK-MEL-2 IC50
7.9 μM
Compound: 5
Cytotoxicity against human SK-MEL-2 cells after 72 hrs by SRB assay
Cytotoxicity against human SK-MEL-2 cells after 72 hrs by SRB assay
[PMID: 12088425]
SK-MEL-28 GI50
4.7 μM
Compound: alpha-Lapachone
Antiproliferative activity against human SK-MEL-28 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human SK-MEL-28 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 22819765]
SW1573 GI50
3.1 μM
Compound: 1a, alpha-lapachone
Growth inhibition of human SW1573 cells by SRB assay
Growth inhibition of human SW1573 cells by SRB assay
[PMID: 22560628]
SW1573 GI50
3.1 μM
Compound: 29
Growth inhibition of human SW1573 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SW1573 cells after 48 hrs by sulforhodamine B assay
[PMID: 20304655]
SW626 IC50
12.4 μM
Compound: 5
Cytotoxicity against human SW626 cells after 72 hrs by SRB assay
Cytotoxicity against human SW626 cells after 72 hrs by SRB assay
[PMID: 12088425]
T47D GI50
25 μM
Compound: 29
Growth inhibition of human T47D cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human T47D cells after 48 hrs by sulforhodamine B assay
[PMID: 20304655]
U-373MG ATCC GI50
23.1 μM
Compound: alpha-Lapachone
Antiproliferative activity against human U373 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against human U373 cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 22819765]
Vero CC50
1.2 μM
Compound: 9
Cytotoxicity against african green monkey Vero cells after 72 hrs by spectrophotometric analysis
Cytotoxicity against african green monkey Vero cells after 72 hrs by spectrophotometric analysis
[PMID: 22795899]
WiDr GI50
26 μM
Compound: 1a, alpha-lapachone
Growth inhibition of human WiDr cells by SRB assay
Growth inhibition of human WiDr cells by SRB assay
[PMID: 22560628]
WiDr GI50
26 μM
Compound: 29
Growth inhibition of human WiDr cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human WiDr cells after 48 hrs by sulforhodamine B assay
[PMID: 20304655]
分子量

242.27

Formula

C15H14O3
CAS 號
性狀

固體

顏色

Light brown to brown

結構分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 100 mg/mL (412.76 mM; 超聲助溶 (<60°C); 吸濕的 DMSO 對產品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 4.1276 mL 20.6381 mL 41.2763 mL
5 mM 0.8255 mL 4.1276 mL 8.2553 mL
查看完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產品資料

純度: 99.65%

參考文獻

完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.1276 mL 20.6381 mL 41.2763 mL 103.1907 mL
5 mM 0.8255 mL 4.1276 mL 8.2553 mL 20.6381 mL
10 mM 0.4128 mL 2.0638 mL 4.1276 mL 10.3191 mL
15 mM 0.2752 mL 1.3759 mL 2.7518 mL 6.8794 mL
20 mM 0.2064 mL 1.0319 mL 2.0638 mL 5.1595 mL
25 mM 0.1651 mL 0.8255 mL 1.6511 mL 4.1276 mL
30 mM 0.1376 mL 0.6879 mL 1.3759 mL 3.4397 mL
40 mM 0.1032 mL 0.5160 mL 1.0319 mL 2.5798 mL
50 mM 0.0826 mL 0.4128 mL 0.8255 mL 2.0638 mL
60 mM 0.0688 mL 0.3440 mL 0.6879 mL 1.7198 mL
80 mM 0.0516 mL 0.2580 mL 0.5160 mL 1.2899 mL
100 mM 0.0413 mL 0.2064 mL 0.4128 mL 1.0319 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
α-Lapachone
目錄號：
HY-N2848
需求量：