成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

  2. NF-κB Immunology/Inflammation Metabolic Enzyme/Protease Anti-infection Apoptosis
  3. Keap1-Nrf2 NF-κB Reactive Oxygen Species SARS-CoV Apoptosis
  4. Danshensu sodium

Danshensu sodium  (Synonyms: 丹參素鈉鹽; Dan shen suan A sodium; Salvianic acid A sodium)

目錄號: HY-N1913A 純度: 98.00%
COA 產品使用指南 技術支持

Danshensu (Dan shen suan A) sodium 是一種具有口服活性的酚類化合物，可誘導 Nrf2/HO-1 激活并抑制 NF-κB 通路。Danshensu sodium 可減少活性氧 (ROS) 的產生，上調抗氧化防御機制并抑制內在的細胞凋亡途徑。Danshensu sodium 對 SARS-CoV-2 顯示出有效的抗病毒活性，EC50 為 0.97 μM。Danshensu sodium 具有抗氧化、抗凋亡、抗肺部炎癥等作用，具有用于 COVID-19、心腦血管等疾病研究的潛力。

MCE 的所有產品僅用作科學研究或藥證申報，我們不為任何個人用途提供產品和服務

Danshensu sodium Chemical Structure

Danshensu sodium Chemical Structure

CAS No. : 81075-52-7

1.  客戶無需承擔相應的運輸費用。

2.  同一機構（單位）同一產品試用裝僅限申領一次，同一機構（單位）一年內

     可免費申領三個不同產品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥783
In-stock
5 mg ￥1959
In-stock
10 mg   詢價  
50 mg   詢價  

* Please select Quantity before adding items.

Customer Review

Other Forms of Danshensu sodium:

MCE 顧客使用本產品發(fā)表的 1 篇科研文獻

查看 NF-κB 亞型特異性產品:

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC50 of 0.97?μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research[1][2][3].

體外研究
(In Vitro)

Danshensu (Dan shen suan A) sodium 有效抑制 SARS-CoV-2 S 蛋白假型病毒 (SARS-CoV-2 S) 進入 ACE2 過表達的 HEK-293T 細胞 (IC50=0.31μM) 和 Vero-E6 細胞 (IC50=4.97μM)[1].
Danshensu (0-100 μM；24小時) sodium 在較高濃度 (50 和 100 μM) 會導致 FaDu 和 Ca9-22 細胞的遷移和侵襲顯著減少[2].
Danshensu (0-100 μM；24小時) sodium 劑量依賴性降低 FaDu 細胞中 ERK 磷酸化和 p38 磷酸化[2].
Danshensu (0-100 μM；24、48、72 小時) sodium 對人口腔癌細胞沒有任何細胞毒性作用[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay [2]

Cell Line: FaDu and Ca9-22 cells
Concentration: 25, 50, and 100 μM
Incubation Time: 24 h
Result: At higher concentrations (50 and 100 μM) caused significant reduction in migration and invasion of both FaDu and Ca9-22 cells.

Western Blot Analysis[2]

Cell Line: FaDu and Ca9-22 cells
Concentration: 25, 50, and 100 μM
Incubation Time: 24 h
Result: Phosphorylation of ERK reduced dose-dependently after 24 h in FaDu cell.
Caused significant reduction in p38 phosphorylation.
體內研究
(In Vivo)

Danshensu (Dan shen suan A; 25、50、100mg/kg；每天口服給藥，連續(xù) 7 天或靜脈注射一次) sodium 在 SARS-CoV-2 S 感染前給藥后，可劑量依賴性地減輕 SARS-CoV-2 S 感染小鼠的病理改變[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult BALB/c mice (male, 6-8 weeks, 20±2?g)[1]
Dosage: 25, 50, 100?mg/kg
Administration: Oral administration (daily for 7 continuous days) or i.v. (once)
Result: Could prevent SARS-CoV-2 S protein-induced acute lung inflammation.
Ameliorated inflammatory cytokines in serum and lung tissue.
分子量

220.15

Formula

C9H9NaO5
CAS 號
性狀

固體

顏色

Off-white to light yellow

中文名稱

丹參素鈉鹽
結構分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

純度 & 產品資料

純度: 98.00%

參考文獻

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的產品:

Your information is safe with us. * Required Fields.

   產品名稱：

  

* 需求量：

* 客戶姓名：

 

* Email：

* 電話：

 

* 公司或機構名稱：

   留言給我們：

Bulk Inquiry

Inquiry Information

產品名稱：
Danshensu sodium
目錄號：
HY-N1913A
需求量：