成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

  2. Metabolic Enzyme/Protease Anti-infection Apoptosis
  3. Endogenous Metabolite Antibiotic Apoptosis
  4. Citric acid monohydrate

Citric acid monohydrate  (Synonyms: 一水檸檬酸)

目錄號: HY-N1428A 純度: ≥98.0%
COA 產(chǎn)品使用指南 技術(shù)支持

Citric acid monohydrate 是一種天然防腐劑和食品酸味增強(qiáng)劑。Citric acid monohydrate誘導(dǎo)細(xì)胞凋亡 (apoptosis) 和細(xì)胞周期停滯在 G2/M 期和 S 期。Citric acid monohydrate 通過降低抗氧化酶活性引起肝臟的氧化損傷。Citric acid monohydrate 對小鼠造成腎毒性。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù)

Citric acid monohydrate Chemical Structure

Citric acid monohydrate Chemical Structure

CAS No. : 5949-29-1

1.  客戶無需承擔(dān)相應(yīng)的運(yùn)輸費(fèi)用。

2.  同一機(jī)構(gòu)（單位）同一產(chǎn)品試用裝僅限申領(lǐng)一次，同一機(jī)構(gòu)（單位）一年內(nèi)

     可免費(fèi)申領(lǐng)三個不同產(chǎn)品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 價格 是否有貨 數(shù)量
5 g ￥100
In-stock
10 g ￥150
In-stock
50 g   詢價  

* Please select Quantity before adding items.

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate causes renal toxicity in mice[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

體外研究
(In Vitro)

Citric acid monohydrate (0-12.5 mM; 24 h) shows antiproliferative activity in a dose dependent manner[3].
Citric acid monohydrate (12.5 mM; 72 h) induces apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner[3].
Citric acid monohydrate (12.5 mM; 48 h) increases the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreases of BCL-2 and BCL-Xl[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: HaCaT cells
Concentration: 0, 2.5, 5, 7.5, 10, 12.5 mM
Incubation Time: 24 h
Result: Inhibited the cell viability in a dose dependent manner.

Cell Cycle Analysis[3]

Cell Line: HaCaT cells
Concentration: 12.5 mM
Incubation Time: 0, 12, 24, 48, 72 h
Result: Induced apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner.

Western Blot Analysis[3]

Cell Line: HaCaT cells
Concentration: 12.5 mM
Incubation Time: 12, 24, 48 h
Result: Increased the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreased of BCL-2 and BCL-Xl.
體內(nèi)研究
(In Vivo)

Citric acid monohydrate (120, 240, and 480 mg/kg; i.p.) significantly decreases GSH-Px activity and induces an increase in the MDA (malonyldialdehyde) levels in mouse liver[1].
Citric acid monohydrate (120, 240, and 480 mg/kg; i.p.) induces apoptosis by increases caspase-3 activity in a dose-dependent manner in mouse hepatocytes[1].
Citric acid monohydrate (120, 240, and 480 mg/kg; i.p.; weekly for 3 weeks) causes renal toxicity in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 20 g male Kunming mice[2]
Dosage: 120, 240, 480 mg/kg
Administration: I.p.; weekly for 3 weeks
Result: T-SOD and GSH-Px activities in the treated groups decreased with increasing doses of citric acid, NOS activity tended to increase, and H2O2 and MDA contents gradually decreased.
Clinical Trial
分子量

210.14

Formula

C6H10O8
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

一水檸檬酸
初始來源

Aspergillus niger
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Store at room temperature, keep dry and cool

In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細(xì)胞實驗： 

DMSO 中的溶解度 : 100 mg/mL (475.87 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 4.7587 mL 23.7937 mL 47.5873 mL
5 mM 0.9517 mL 4.7587 mL 9.5175 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用，-20°C儲存時，請在1年內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用，-20°C儲存時，請在1年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.7587 mL 23.7937 mL 47.5873 mL 118.9683 mL
5 mM 0.9517 mL 4.7587 mL 9.5175 mL 23.7937 mL
10 mM 0.4759 mL 2.3794 mL 4.7587 mL 11.8968 mL
15 mM 0.3172 mL 1.5862 mL 3.1725 mL 7.9312 mL
20 mM 0.2379 mL 1.1897 mL 2.3794 mL 5.9484 mL
25 mM 0.1903 mL 0.9517 mL 1.9035 mL 4.7587 mL
30 mM 0.1586 mL 0.7931 mL 1.5862 mL 3.9656 mL
40 mM 0.1190 mL 0.5948 mL 1.1897 mL 2.9742 mL
50 mM 0.0952 mL 0.4759 mL 0.9517 mL 2.3794 mL
60 mM 0.0793 mL 0.3966 mL 0.7931 mL 1.9828 mL
80 mM 0.0595 mL 0.2974 mL 0.5948 mL 1.4871 mL
100 mM 0.0476 mL 0.2379 mL 0.4759 mL 1.1897 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的產(chǎn)品:

Your information is safe with us. * Required Fields.

   產(chǎn)品名稱：

  

* 需求量：

* 客戶姓名：

 

* Email：

* 電話：

 

* 公司或機(jī)構(gòu)名稱：

   留言給我們：

Bulk Inquiry

Inquiry Information

產(chǎn)品名稱：
Citric acid monohydrate
目錄號：
HY-N1428A
需求量：