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  2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species Endogenous Metabolite
  4. AKBA

AKBA  (Synonyms: Acetyl-11-keto-β-boswellic acid)

目錄號: HY-N0892 純度: 99.93%
COA 產(chǎn)品使用指南

AKBA (Acetyl-11-keto-β-boswellic acid) 是一種從乳香中提取出的活性化合物，是新穎的 Nrf2 的活化劑。

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AKBA Chemical Structure

AKBA Chemical Structure

CAS No. : 67416-61-9

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥1466
In-stock
1 mg ￥594
In-stock
5 mg ￥1300
In-stock
10 mg ￥2300
In-stock
50 mg   詢價  
100 mg   詢價  

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Customer Review

Other Forms of AKBA:

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻

查看 HIF/HIF Prolyl-Hydroxylase 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

生物活性

AKBA (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator.

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
A253 cell line IC50
16.9 μM
Compound: 4, (beta-AKBA)
Cytotoxicity against human A253 cells assessed as cell survival after 96 hrs by SRB assay
Cytotoxicity against human A253 cells assessed as cell survival after 96 hrs by SRB assay
[PMID: 25618017]
A2780 IC50
14.1 μM
Compound: 4, (beta-AKBA)
Cytotoxicity against human A2780 cells assessed as cell survival after 96 hrs by SRB assay
Cytotoxicity against human A2780 cells assessed as cell survival after 96 hrs by SRB assay
[PMID: 25618017]
A549 IC50
3 μM
Compound: 4
Inhibition of microsomal PGES1 isolated from IL-1beta-stimulated human A549 cells preincubated for 15 mins followed by substrate addition measured after 1 min by RP-HPLC analysis
Inhibition of microsomal PGES1 isolated from IL-1beta-stimulated human A549 cells preincubated for 15 mins followed by substrate addition measured after 1 min by RP-HPLC analysis
[PMID: 24844534]
DLD-1 IC50
20.9 μM
Compound: 4, (beta-AKBA)
Cytotoxicity against human DLD1 cells assessed as cell survival after 96 hrs by SRB assay
Cytotoxicity against human DLD1 cells assessed as cell survival after 96 hrs by SRB assay
[PMID: 25618017]
HCT-8 IC50
17.5 μM
Compound: 4, (beta-AKBA)
Cytotoxicity against human HCT8 cells assessed as cell survival after 96 hrs by SRB assay
Cytotoxicity against human HCT8 cells assessed as cell survival after 96 hrs by SRB assay
[PMID: 25618017]
HeLa IC50
31 μM
Compound: 4, AKBA
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
[PMID: 21334793]
HL-60 IC50
11 μM
Compound: 4, AKBA
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
[PMID: 21334793]
HT-29 IC50
19.4 μM
Compound: 4, (beta-AKBA)
Cytotoxicity against human HT-29 cells assessed as cell survival after 96 hrs by SRB assay
Cytotoxicity against human HT-29 cells assessed as cell survival after 96 hrs by SRB assay
[PMID: 25618017]
HUVEC IC50
7.45 μM
Compound: 1, AKBA
Antiproliferation activity against HUVEC cells after 48 hrs by CCK-8 assay
Antiproliferation activity against HUVEC cells after 48 hrs by CCK-8 assay
[PMID: 25819335]
LNCaP GI50
27.43 μM
Compound: AKBA
Anti-proliferative activity against human LNCAP cells measured after 96 hrs by MTT assay
Anti-proliferative activity against human LNCAP cells measured after 96 hrs by MTT assay
[PMID: 27997878]
PC-3 GI50
31.86 μM
Compound: AKBA
Anti-proliferative activity against human PC3 cells measured after 96 hrs by MTT assay
Anti-proliferative activity against human PC3 cells measured after 96 hrs by MTT assay
[PMID: 27997878]
PC-3 GI50
31.9 μM
Compound: 1; AKBA
Antiproliferative activity against human PC3 cells after 96 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 96 hrs by MTT assay
[PMID: 30153964]
RAW264.7 IC50
15.6 μM
Compound: AKBA
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs
[PMID: 23391590]
Sf21 IC50
> 40 μM
Compound: 29
Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis
Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis
[PMID: 31774676]
體外研究
(In Vitro)

AKBA (Acetyl-11-keto-β-boswellic acid) 顯著減少梗塞體積和凋亡細胞，并通過提高 48 小時大腦中動脈閉塞 (MCAO) 大鼠腦組織中 Nrf2 和 HO-1 的表達來增加神經(jīng)系統(tǒng)評分再灌注后。在原代培養(yǎng)的神經(jīng)元中，AKBA 增加了 Nrf2 和 HO-1 的表達，從而防止 OGD 誘導的氧化損傷。此外，AKBA 處理增加了 Nrf2 與抗氧化反應元件 (ARE) 的結合活性[1]。
AKBA (乙?；?11-酮基-β-乳香酸) 顯著抑制人結腸腺癌的生長，表明細胞周期停滯在 G1 期并誘導細胞凋亡[3]。
AKBA (乙?；?11-酮基-β-乳香酸) 在 3T3-L1 中引發(fā)顯著的脂肪分解脂肪細胞，如胞質(zhì)溶膠中中性脂質(zhì)減少和培養(yǎng)基中游離脂肪酸增加所示。AKBA 增加的脂肪分解伴隨著脂肪分解酶、脂肪細胞甘油三酯脂肪酶 (ATGL) 和激素敏感性脂肪酶 (HSL) 的上調(diào)，以及脂滴穩(wěn)定性調(diào)節(jié)因子 perilipin 的表達減少。此外，AKBA (Acetyl-11-keto-β-boswellic acid) 處理減少了成熟脂肪細胞中成熟脂肪細胞 aP2、脂聯(lián)素和 glut-4 的表型標記[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

AKBA (Acetyl-11-keto-β-boswellic acid) 顯著阻止了腸腺瘤性息肉的形成，對小鼠沒有毒性。AKBA 在預防小腸和結腸息肉方面的活性比阿司匹林更有效。組織病理學檢查顯示 AKBA 的作用，即減少息肉大小和異型增生程度，在較大尺寸的息肉中更為突出，尤其是那些起源于結腸的息肉[1]。
AKBA 在小鼠中給藥有效地延遲了 HT-29 異種移植物的生長而沒有毒性跡象。AKBA 的活性比阿司匹林強[3]。
AKBA 在體外和體內(nèi)均表現(xiàn)出抗癌活性。通過在小鼠中口服應用，AKBA 可顯著抑制 SGC-7901 和 MKN-45 異種移植物，且無毒性[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

512.72

Formula

C32H48O5
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

3-乙?；?11-酮基-β-乳香酸
結構分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : ≥ 5.2 mg/mL (10.14 mM; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 1.9504 mL 9.7519 mL 19.5038 mL
5 mM 0.3901 mL 1.9504 mL 3.9008 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.93%

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9504 mL 9.7519 mL 19.5038 mL 48.7596 mL
5 mM 0.3901 mL 1.9504 mL 3.9008 mL 9.7519 mL
10 mM 0.1950 mL 0.9752 mL 1.9504 mL 4.8760 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
AKBA
目錄號：
HY-N0892
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