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  2. Autophagy
  3. Autophagy
  4. Pterostilbene

Pterostilbene 是從藍(lán)莓和囊狀紫檀中得到的芪類化合物，具有抗氧化、抗炎、抗癌、抗糖尿病和抗肥胖等功效。Pterostilbene 抑制 ROS 的生成，能對(duì)抗多種自由基，例如 DPPH，ABTS，hydroxyl，superoxide 和 hydrogen peroxide 等。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Pterostilbene Chemical Structure

Pterostilbene Chemical Structure

CAS No. : 537-42-8

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥550
In-stock
5 mg ￥164
In-stock
10 mg ￥263
In-stock
25 mg ￥500
In-stock
50 mg ￥750
In-stock
100 mg ￥1100
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200 mg   詢價(jià)  
500 mg   詢價(jià)  

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Customer Review

Other Forms of Pterostilbene:

    Pterostilbene purchased from MCE. Usage Cited in: Arch Biochem Biophys. 2023 Mar 9;738:109561.  [Abstract]

    Pterostilbene (20 μM; 6 h) can reverse the changes of ferroptosis-related proteins in OGCs (COV434 and KGN cells) induced by H2O2. Pterostilbene significantly increases the expression of GPX4 while decreases the expression of ACSL4.

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium[1]. Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties[1][4]. Pterostilbene blocks ROS production[3], also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide[4].

    細(xì)胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    518A2 IC50
    17.39 μM
    Compound: 21
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    A253 cell line IC50
    17.33 μM
    Compound: 21
    Cytotoxicity against human A253 cells after 96 hrs by SRB assay
    Cytotoxicity against human A253 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    A2780 IC50
    15.56 μM
    Compound: 21
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    A549 IC50
    15.86 μM
    Compound: 21
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    Cytotoxicity against human A549 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    A549 IC50
    26 μM
    Compound: Pter
    Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    		[PMID: 28654265]
    A549 IC50
    71.7 μM
    Compound: 6
    Cytotoxicity against human A549 cells after 72 hrs by MTT assay
    Cytotoxicity against human A549 cells after 72 hrs by MTT assay
    		[PMID: 19689125]
    B16-BL6 IC50
    15.9 μM
    Compound: 6
    Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
    Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
    		[PMID: 19689125]
    BXPC-3 IC50
    31 μM
    Compound: Pter
    Cytotoxicity against human BxPC3 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human BxPC3 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    		[PMID: 28654265]
    Caco-2 IC50
    14.46 μM
    Compound: 16, Pterostilbene
    Cytotoxicity against human Caco-2 cells after 3 days by [3H]thymidine incorporation assay
    Cytotoxicity against human Caco-2 cells after 3 days by [3H]thymidine incorporation assay
    		[PMID: 20627379]
    COLO 201 IC50
    29 μM
    Compound: Pter
    Cytotoxicity against human COLO201 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human COLO201 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    		[PMID: 28654265]
    DLD-1 IC50
    16.45 μM
    Compound: 21
    Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay
    Cytotoxicity against human DLD1 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    DU-145 GI50
    4.3 μg/mL
    Compound: 14d
    The concentration causing 50% reduction in the net protein increase (cell growth inhibition, GI50) against central nervous system (CNS) SF-268 cells
    The concentration causing 50% reduction in the net protein increase (cell growth inhibition, GI50) against central nervous system (CNS) SF-268 cells
    		[PMID: 12036362]
    HCT-116 IC50
    > 60 μM
    Compound: 2
    Cytotoxicity against human HCT116 cells assessed as inhibition of cell growth after 24 hrs by MTT assay
    Cytotoxicity against human HCT116 cells assessed as inhibition of cell growth after 24 hrs by MTT assay
    		[PMID: 26204233]
    HCT-116 IC50
    34.08 μM
    Compound: PTE
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 34043359]
    HEK293 IC50
    19.5 μM
    Compound: 1H6
    Inhibition of TNFalpha induced NF-kappaB activation in human 293 cells after 24 hrs by luciferase reporter gene assay
    Inhibition of TNFalpha induced NF-kappaB activation in human 293 cells after 24 hrs by luciferase reporter gene assay
    		[PMID: 18487053]
    HeLa IC50
    9.43 μM
    Compound: 6
    Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
    		[PMID: 19689125]
    HT-1080 IC50
    93.4 μM
    Compound: 6
    Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
    Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
    		[PMID: 19689125]
    HT-29 IC50
    > 60 μM
    Compound: 2
    Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth after 24 hrs by MTT assay
    Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth after 24 hrs by MTT assay
    		[PMID: 26204233]
    HT-29 IC50
    23.8 μM
    Compound: 16, Pterostilbene
    Cytotoxicity against human HT-29 cells after 3 days by [3H]thymidine incorporation assay
    Cytotoxicity against human HT-29 cells after 3 days by [3H]thymidine incorporation assay
    		[PMID: 20627379]
    HT-29 IC50
    28 μM
    Compound: Pter
    Cytotoxicity against human HT-29 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human HT-29 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    		[PMID: 28654265]
    J774 IC50
    10.5 μM
    Compound: 4
    Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced MCP1 expression after 24 hrs by ELISA
    Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced MCP1 expression after 24 hrs by ELISA
    		[PMID: 29726680]
    J774 IC50
    16.7 μM
    Compound: 4
    Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced nitric oxide production after 24 hrs by Griess assay
    Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced nitric oxide production after 24 hrs by Griess assay
    		[PMID: 29726680]
    J774 IC50
    8.7 μM
    Compound: 4
    Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced IL6 expression after 24 hrs by ELISA
    Antiinflammatory activity in mouse J774 cells assessed as reduction in LPS-induced IL6 expression after 24 hrs by ELISA
    		[PMID: 29726680]
    L02 IC50
    > 100 μM
    Compound: Pter
    Cytotoxicity against human L-02 cells incubated for 24 hrs by MTT assay
    Cytotoxicity against human L-02 cells incubated for 24 hrs by MTT assay
    		[PMID: 34506712]
    LN-229 IC50
    14 μM
    Compound: Pter
    Cytotoxicity against human LN229 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human LN229 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    		[PMID: 28654265]
    MCF7 IC50
    14.11 μM
    Compound: 21
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    MCF7 IC50
    65 μM
    Compound: Pterostlibene
    Cytotoxicity against human MCF7 cells measured 24 hrs by MTT assay
    Cytotoxicity against human MCF7 cells measured 24 hrs by MTT assay
    		[PMID: 27598238]
    MDA-MB-231 IC50
    31.17 μM
    Compound: PTE
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 34043359]
    MDA-MB-231 IC50
    63 μM
    Compound: Pter
    Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    		[PMID: 28654265]
    NCI-H460 IC50
    17 μM
    Compound: Pter
    Cytotoxicity against human NCI-H460 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human NCI-H460 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    		[PMID: 28654265]
    NIH3T3 IC50
    12.19 μM
    Compound: 21
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
    		[PMID: 22749392]
    NIH3T3 IC50
    12.2 μM
    Compound: 16
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by sulforhodamine-B colorimetric assay
    Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by sulforhodamine-B colorimetric assay
    		[PMID: 21803587]
    PANC-1 IC50
    50 μM
    Compound: Pter
    Cytotoxicity against human PANC1 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human PANC1 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    		[PMID: 28654265]
    RAW264.7 IC50
    30 μM
    Compound: 1b
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS/IFNgamma-induced NO production by measuring NO level preincubated for 2 hrs and followed by LPS/IFNgamma addition and measured after 24 hrs by Griess assay
    Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS/IFNgamma-induced NO production by measuring NO level preincubated for 2 hrs and followed by LPS/IFNgamma addition and measured after 24 hrs by Griess assay
    		[PMID: 31350127]
    SK-MEL-2 IC50
    17 μM
    Compound: Pter
    Cytotoxicity against human SK-MEL-2 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human SK-MEL-2 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    		[PMID: 28654265]
    T47D IC50
    35 μM
    Compound: Pter
    Cytotoxicity against human T47D cells assessed as decrease in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human T47D cells assessed as decrease in cell viability after 48 hrs by MTT assay
    		[PMID: 28654265]
    U-87MG ATCC IC50
    34 μM
    Compound: Pter
    Cytotoxicity against human U87 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    Cytotoxicity against human U87 cells assessed as decrease in cell viability after 48 hrs by MTT assay
    		[PMID: 28654265]
    體外研究
    (In Vitro)

    Pterostilbene (0, 5, 25, 50, 100, 200 and 400 μM) shows inhibitory activity against the growth of HeLa cells, with IC50s of 101.2 μM and 65.9 μM at 24 and 48 hrs, respectively. Ipterostilbene (0, 25, 100 and 200 μM) also induces the apoptosis HeLa cells[2].
    Pterostilbene (0.05, 0.1, 0.15 and 0.2 mM) has high anti-oxidant activity against DPPH, ABTS, hydroxyl, superoxide, hydrogen peroxide in a dose-dependent manner. Pterostilbene decreases lipid peroxides and hydroperoxides, reduces protein carbonyl groups and restores protein sulphydryl groups in response to damage by TBHP and As-Fe2+. Pterostilbene also inhibits single strand breaks in pBR322[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    體內(nèi)研究
    (In Vivo)

    Pterostilbene (30 mg/kg daily, p.o. for 21 days) inhibits reactive oxygen species production in the animal model of inflammation[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    256.30

    Formula

    C16H16O3
    CAS 號(hào)
    性狀

    固體

    顏色

    White to off-white

    中文名稱

    紫檀茋
    結(jié)構(gòu)分類
    初始來源
    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲(chǔ)存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 1 year
    -20°C 6 months
    溶解性數(shù)據(jù)
    細(xì)胞實(shí)驗(yàn)： 

    DMSO 中的溶解度 : 110 mg/mL (429.18 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

    配制儲(chǔ)備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 3.9017 mL 19.5084 mL 39.0168 mL
    5 mM 0.7803 mL 3.9017 mL 7.8034 mL
    查看完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

    • 摩爾計(jì)算器

    • 稀釋計(jì)算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動(dòng)物實(shí)驗(yàn)：

    請(qǐng)根據(jù)您的 實(shí)驗(yàn)動(dòng)物和給藥方式 選擇適當(dāng)?shù)娜芙夥桨浮?

    以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：
    ——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
    以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

    • 方案 一

      請(qǐng)依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 3.93 mg/mL (15.33 mM); 澄清溶液

      此方案可獲得 ≥ 3.93 mg/mL（飽和度未知）的澄清溶液。

      以 1 mL 工作液為例，取 100 μL 39.3 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水 定容至 1 mL。

      生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
    • 方案 二

      請(qǐng)依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.75 mg/mL (10.73 mM); 澄清溶液

      此方案可獲得 ≥ 2.75 mg/mL（飽和度未知）的澄清溶液。

      以 1 mL 工作液為例，取 100 μL 27.5 mg/mL 的澄清 DMSO 儲(chǔ)備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液 中，混合均勻。

      2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。
    動(dòng)物溶解方案計(jì)算器
    請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

    給藥劑量

    mg/kg

    動(dòng)物的平均體重

    g

    每只動(dòng)物的給藥體積

    μL

    動(dòng)物數(shù)量

    只
    由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量
    請(qǐng)輸入您的動(dòng)物體內(nèi)配方組成：
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    如果您的動(dòng)物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。
    方案所需 助溶劑 包括：DMSO， ，均可在 MCE 網(wǎng)站選購(gòu)。 ，Tween 80，均可在 MCE 網(wǎng)站選購(gòu)。
    計(jì)算結(jié)果
    工作液所需濃度 : mg/mL
    儲(chǔ)備液配制方法 : mg 藥物溶于 μL  DMSO（母液濃度為 mg/mL）。
    您所需的儲(chǔ)備液濃度超過該產(chǎn)品的實(shí)測(cè)溶解度，以下方案僅供參考，如有需要，請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。
    動(dòng)物實(shí)驗(yàn)體內(nèi)工作液的配制方法 : 取 μL DMSO 儲(chǔ)備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。
    連續(xù)給藥周期超過半月以上，請(qǐng)謹(jǐn)慎選擇該方案。
    請(qǐng)確保第一步儲(chǔ)備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱 （超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。
    純度 & 產(chǎn)品資料

    純度: 99.90%

    參考文獻(xiàn)

    完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?年內(nèi)使用， -20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.9017 mL 19.5084 mL 39.0168 mL 97.5419 mL
    5 mM 0.7803 mL 3.9017 mL 7.8034 mL 19.5084 mL
    10 mM 0.3902 mL 1.9508 mL 3.9017 mL 9.7542 mL
    15 mM 0.2601 mL 1.3006 mL 2.6011 mL 6.5028 mL
    20 mM 0.1951 mL 0.9754 mL 1.9508 mL 4.8771 mL
    25 mM 0.1561 mL 0.7803 mL 1.5607 mL 3.9017 mL
    30 mM 0.1301 mL 0.6503 mL 1.3006 mL 3.2514 mL
    40 mM 0.0975 mL 0.4877 mL 0.9754 mL 2.4385 mL
    50 mM 0.0780 mL 0.3902 mL 0.7803 mL 1.9508 mL
    60 mM 0.0650 mL 0.3251 mL 0.6503 mL 1.6257 mL
    80 mM 0.0488 mL 0.2439 mL 0.4877 mL 1.2193 mL
    100 mM 0.0390 mL 0.1951 mL 0.3902 mL 0.9754 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    產(chǎn)品名稱：
    Pterostilbene
    目錄號(hào)：
    HY-N0828
    需求量：