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  2. Metabolic Enzyme/Protease
  3. Indoleamine 2,3-Dioxygenase (IDO)
  4. (S)-Indoximod

(S)-Indoximod  (Synonyms: 1-Methyl-L-tryptophan; (S)-NLG-8189)

目錄號(hào): HY-N0707 純度: 99.47%
COA 產(chǎn)品使用指南 技術(shù)支持

(S)-Indoximod (1-Methyl-L-tryptophan) 是吲哚胺-2,3-雙加氧酶 (IDO) 抑制劑 (Ki: 19 μM)。(S)-Indoximod 可用于癌癥和神經(jīng)疾病研究。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

(S)-Indoximod Chemical Structure

(S)-Indoximod Chemical Structure

CAS No. : 21339-55-9

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100 mg ￥200
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500 mg ￥320
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1 g   詢價(jià)  
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Other Forms of (S)-Indoximod:

查看 Indoleamine 2,3-Dioxygenase (IDO) 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

(S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO) (Ki: 19 μM). (S)-Indoximod can be used for the research of cancer and neurological disease[1][2][3][4].

IC50 & Target

Indoleamine 2,3-Dioxygenase (IDO)[1]
細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
18.4 μM
Compound: 1-L-MT
Inhibition of human IDO1 expressed in HEK293 cells assessed as kynurenine release after 5 hrs by spectrophotometry
Inhibition of human IDO1 expressed in HEK293 cells assessed as kynurenine release after 5 hrs by spectrophotometry
[PMID: 24099220]
HEK293 IC50
18.4 μM
Compound: 1-L-MT
Inhibition of recombinant human IDO1 expressed in HEK293 cells assessed as reduction in kynurenine formation after 5 hrs by microplate reader analysis
Inhibition of recombinant human IDO1 expressed in HEK293 cells assessed as reduction in kynurenine formation after 5 hrs by microplate reader analysis
[PMID: 31580660]
HEK293 IC50
90 μM
Compound: L-1MT
Inhibition of human recombinant IDO expressed in HEK293 cells assessed as blockade of tryptophan degradation by HPLC
Inhibition of human recombinant IDO expressed in HEK293 cells assessed as blockade of tryptophan degradation by HPLC
[PMID: 20055453]
HeLa IC50
118.5 μM
Compound: L-1-MT
Inhibition of IDO1 in interferon-gamma-induced human HeLa cells using L-tryptophan substrate incubated for 24 hrs
Inhibition of IDO1 in interferon-gamma-induced human HeLa cells using L-tryptophan substrate incubated for 24 hrs
[PMID: 31178268]
MDA-MB-231 EC50
120 μM
Compound: L-1MT
Inhibition of IDO1 in IFNgamma-induced human MDA-MB-231 cells using tryptophan as substrate preincubated for 4 hrs followed by substrate addition for 5 hrs by spectrophotometric method
Inhibition of IDO1 in IFNgamma-induced human MDA-MB-231 cells using tryptophan as substrate preincubated for 4 hrs followed by substrate addition for 5 hrs by spectrophotometric method
[PMID: 27994758]
U-87MG ATCC IC50
56.9 μM
Compound: 1-L-MT
Inhibition of recombinant human IDO2 expressed in human U87MG cells assessed as reduction in kynurenine formation using L-tryptophan as substrate after 6 hrs by spectrophotometry
Inhibition of recombinant human IDO2 expressed in human U87MG cells assessed as reduction in kynurenine formation using L-tryptophan as substrate after 6 hrs by spectrophotometry
[PMID: 27475108]
體外研究
(In Vitro)

(S)-Indoximod (750 μM，24 小時(shí)) 可降低轉(zhuǎn)導(dǎo)人 IDO1 基因的 HEK293 細(xì)胞中的 IDO 活性[4]。
(S)-Indoximod (0.5 mM, 48 h) 使肝星狀細(xì)胞細(xì)胞從 IFN-γ (100 ng/mL) 介導(dǎo)的 G1 細(xì)胞周期阻滯中釋放出來，進(jìn)而促進(jìn)細(xì)胞凋亡[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

(S)-Indoximod (5 mg/天，腹腔注射，持續(xù) 3 周) 可逆轉(zhuǎn)卡介苗 (BCG) 誘導(dǎo)的小鼠神經(jīng)毒性[3]。
(S)-Indoximod (200 mg/kg，口服灌胃) 比 D 異構(gòu)體表現(xiàn)出延遲、持續(xù)時(shí)間更長(zhǎng)的腎臟保護(hù)作用，并提高 IRI 大鼠模型的存活率[4]。
(S)-Indoximod (1-9 mg/kg，腹腔注射) 可逆轉(zhuǎn)膽管結(jié)扎 (BDL) 大鼠的認(rèn)知、焦慮和抑郁樣行為[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Bile duct ligation (BDL) rats[5]
Dosage: 1-9 mg/kg
Administration: i.p., After the rats recovered for 7 days from BDL surgery.
Result: Increased the sucrose preference.
Prevents the increased number of buried marbles.
Improved learning and memory function.
分子量

218.25

Formula

C12H14N2O2
CAS 號(hào)
性狀

固體

顏色

White to off-white

中文名稱

相思豆堿
結(jié)構(gòu)分類
初始來源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 4.81 mg/mL (22.04 mM; ultrasonic and warming and adjust pH to 4 with HCl and heat to 60°C; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 4.5819 mL 22.9095 mL 45.8190 mL
5 mM 0.9164 mL 4.5819 mL 9.1638 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物實(shí)驗(yàn)：

以下溶解方案，請(qǐng)直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

  • 方案 一

    請(qǐng)依序添加每種溶劑： 50% PEG300    50% Saline

    Solubility: 5 mg/mL (22.91 mM); 懸濁液; 超聲助溶

  • 方案 二

    請(qǐng)依序添加每種溶劑： 15% Cremophor EL    85% Saline

    Solubility: 20 mg/mL (91.64 mM); 懸濁液; 超聲助溶

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.47%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.5819 mL 22.9095 mL 45.8190 mL 114.5475 mL
5 mM 0.9164 mL 4.5819 mL 9.1638 mL 22.9095 mL
10 mM 0.4582 mL 2.2910 mL 4.5819 mL 11.4548 mL
15 mM 0.3055 mL 1.5273 mL 3.0546 mL 7.6365 mL
20 mM 0.2291 mL 1.1455 mL 2.2910 mL 5.7274 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
(S)-Indoximod
目錄號(hào)：
HY-N0707
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