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  2. Metabolic Enzyme/Protease Autophagy Anti-infection
  3. HIF/HIF Prolyl-Hydroxylase Autophagy Virus Protease
  4. Oroxylin A

Oroxylin A  (Synonyms: 千層紙素A; Baicalein 6-methyl ether; 6-Methoxybaicalein)

目錄號: HY-N0560 純度: 99.74%
COA 產(chǎn)品使用指南 技術(shù)支持

千層紙素 (Oroxylin A) 是一種有活性的黃酮類化合物，具有較強(qiáng)的抗癌作用。Oroxylin A 可抑制 IL-6/STAT3 通路和 NF-κB 信號傳導(dǎo)，抑制細(xì)胞增殖并誘導(dǎo)細(xì)胞凋亡 (apoptosis)。Oroxylin A 可抑制結(jié)腸炎相關(guān)的癌發(fā)生。

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Oroxylin A Chemical Structure

Oroxylin A Chemical Structure

CAS No. : 480-11-5

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥524
In-stock
5 mg ￥477
In-stock
10 mg ￥716
In-stock
25 mg ￥1290
In-stock
50 mg ￥1800
In-stock
100 mg ￥2520
In-stock
200 mg   詢價  
500 mg   詢價  

* Please select Quantity before adding items.

Customer Review

Other Forms of Oroxylin A:

查看 HIF/HIF Prolyl-Hydroxylase 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Oroxylin A is an active flavonoid compound with strong anti-cancer effects. Oroxylin A inhibits the IL-6/STAT3 pathway and NF-κB signaling, inhibits cell proliferation and induces apoptosis. Oroxylin A inhibits colitis-related carcinogenesis[1][2][3][4][5].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
33.9 μM
Compound: 1, Oroxylin A
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 22196122]
HepG2 IC50
22.7 μM
Compound: 1, Oroxylin A
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 22196122]
HUVEC IC50
61 μM
Compound: 5
Inhibition of trypsin-induced elevation in PAI1 production in HUVEC by ELISA
Inhibition of trypsin-induced elevation in PAI1 production in HUVEC by ELISA
[PMID: 9214730]
KB IC50
16.1 μM
Compound: O, oroxylin-A
Cytotoxicity against multi-drug resistant human KB cells overexpressing mdr1 after 3 days
Cytotoxicity against multi-drug resistant human KB cells overexpressing mdr1 after 3 days
[PMID: 18722769]
KB IC50
31.1 μM
Compound: O, oroxylin-A
Cytotoxicity against human KB cells after 3 days
Cytotoxicity against human KB cells after 3 days
[PMID: 18722769]
MV4-11 GI50
5.59 μM
Compound: 14, Oroxylin
Cytotoxicity against human MV4-11 cells harboring FLT3 mutation after 72 hrs by tetrazolium based Ez CyTox cell viability assay
Cytotoxicity against human MV4-11 cells harboring FLT3 mutation after 72 hrs by tetrazolium based Ez CyTox cell viability assay
[PMID: 23411073]
RS4-11 GI50
40 μM
Compound: 14, Oroxylin
Cytotoxicity against human RS4:11 cells harboring wild type FLT3 after 72 hrs by tetrazolium based Ez CyTox cell viability assay
Cytotoxicity against human RS4:11 cells harboring wild type FLT3 after 72 hrs by tetrazolium based Ez CyTox cell viability assay
[PMID: 23411073]
體外研究
(In Vitro)

Oroxylin A (20 μM; 24 h) 抑制 MDA-MB-231 細(xì)胞的生長、增殖、遷徙。Oroxylin A 還抑制 MDA-MB-231 的侵襲，抑制其上皮-間質(zhì)轉(zhuǎn)化 (EMT) 過程[4]。
Oroxylin A (20 μM; 24 h) 還抑制促炎細(xì)胞因子表達(dá)，抑制 NF-κB 信號通路[4]。
Oroxylin A 的抗炎作用會被 TNF-α 消弭[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

284.26

Formula

C16H12O5
CAS 號
性狀

固體

顏色

Light yellow to yellow

中文名稱

千層紙素A
結(jié)構(gòu)分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細(xì)胞實驗： 

DMSO 中的溶解度 : ≥ 32 mg/mL (112.57 mM; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 3.5179 mL 17.5895 mL 35.1791 mL
5 mM 0.7036 mL 3.5179 mL 7.0358 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.87%

參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5179 mL 17.5895 mL 35.1791 mL 87.9477 mL
5 mM 0.7036 mL 3.5179 mL 7.0358 mL 17.5895 mL
10 mM 0.3518 mL 1.7590 mL 3.5179 mL 8.7948 mL
15 mM 0.2345 mL 1.1726 mL 2.3453 mL 5.8632 mL
20 mM 0.1759 mL 0.8795 mL 1.7590 mL 4.3974 mL
25 mM 0.1407 mL 0.7036 mL 1.4072 mL 3.5179 mL
30 mM 0.1173 mL 0.5863 mL 1.1726 mL 2.9316 mL
40 mM 0.0879 mL 0.4397 mL 0.8795 mL 2.1987 mL
50 mM 0.0704 mL 0.3518 mL 0.7036 mL 1.7590 mL
60 mM 0.0586 mL 0.2932 mL 0.5863 mL 1.4658 mL
80 mM 0.0440 mL 0.2199 mL 0.4397 mL 1.0993 mL
100 mM 0.0352 mL 0.1759 mL 0.3518 mL 0.8795 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Oroxylin A
目錄號：
HY-N0560
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