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  2. Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt NF-κB Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation
  3. JAK Keap1-Nrf2 Apoptosis β-catenin Reactive Oxygen Species
  4. Pentagalloylglucose

Pentagalloylglucose  (Synonyms: Penta-O-galloyl-β-D-glucose; 1,2,3,4,6-Pentagalloyl glucose)

目錄號(hào): HY-N0527 純度: 99.77%
COA 產(chǎn)品使用指南 技術(shù)支持

Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) 是一種口服有效的沒(méi)食子單寧化合物，也是凋亡 (apoptosis) 和自噬 (autophagy) 誘導(dǎo)劑。Pentagalloylglucose 通過(guò) GSK3β/β-catenin 途徑誘導(dǎo)細(xì)胞凋亡自噬。Pentagalloylglucose 具有抗氧化、抗誘變、抗炎、抗驚厥、心臟保護(hù)、抗過(guò)敏、降膽甾醇血癥和抗腫瘤活性。

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Pentagalloylglucose Chemical Structure

Pentagalloylglucose Chemical Structure

CAS No. : 14937-32-7

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥828
In-stock
1 mg ￥251
In-stock
5 mg ￥550
In-stock
10 mg ￥800
In-stock
25 mg ￥1520
In-stock
50 mg ￥2363
In-stock
100 mg ￥3538
In-stock
500 mg 現(xiàn)貨 詢(xún)價(jià)
1 g   詢(xún)價(jià)  
5 g   詢(xún)價(jià)  

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Customer Review

Other Forms of Pentagalloylglucose:

    Pentagalloylglucose purchased from MCE. Usage Cited in: Gastroenterology. 2023 Jun;164(7):1232-1247.  [Abstract]

    In human PC organoids, Pentagalloylglucose (PGG; 100 nM) upregulates p53, decreases RRM1 and RRM2 levels, and aggravates gemcitabine-induced replication stress.

    Pentagalloylglucose purchased from MCE. Usage Cited in: Viruses. 2018 Apr 17;10(4). pii: E201.  [Abstract]

    After incubation with PGG and IPS, RABV is inoculated with BHK-21 cells for 48 h, and the expression level of viral P is analyzed by Western blotting.

    查看 JAK 亞型特異性產(chǎn)品:

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities[1][2][3].
    細(xì)胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    A549 ED50
    > 10 μg/mL
    Compound: 10
    Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay
    Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay
    		[PMID: 1431932]
    HCT-116 IC50
    1.61 μM
    Compound: PGG
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability by MTT assay
    Cytotoxicity against human HCT116 cells assessed as reduction in cell viability by MTT assay
    		[PMID: 29778287]
    HCT-8 ED50
    > 10 μg/mL
    Compound: 10
    Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay
    Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay
    		[PMID: 1431932]
    HeLa IC50
    356.3 μM
    Compound: 8
    Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay
    Cytotoxicity against human HeLa cells assessed as cell viability after 48 hrs by MTT assay
    		[PMID: 24613627]
    HepG2 IC50
    92.4 μM
    Compound: 8
    Cytotoxicity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay
    		[PMID: 24613627]
    HT-29 IC50
    28 μg/mL
    Compound: PGG
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
    		[PMID: 22216935]
    HT-29 IC50
    34 μg/mL
    Compound: PGG
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay in presence of H2O2 scavenger catalase
    Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay in presence of H2O2 scavenger catalase
    		[PMID: 22216935]
    HT-29 IC50
    4.46 μM
    Compound: PGG
    Cytotoxicity against human HT-29 cells assessed as reduction in cell viability by MTT assay
    Cytotoxicity against human HT-29 cells assessed as reduction in cell viability by MTT assay
    		[PMID: 29778287]
    KB ED50
    > 10 μg/mL
    Compound: 10
    Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay
    Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay
    		[PMID: 1431932]
    MDA-MB-231 IC50
    9.12 μM
    Compound: 5
    Cytotoxicity against human MDA-MB-231 cells expressing CD73 assessed as reduction in cell viability by CCK8 assay
    Cytotoxicity against human MDA-MB-231 cells expressing CD73 assessed as reduction in cell viability by CCK8 assay
    		[PMID: 33359608]
    MIA PaCa-2 IC50
    72.59 μM
    Compound: 5
    Cytotoxicity against human MIA PaCa-2 cells expressing CD73 assessed as reduction in cell viability by CCK8 assay
    Cytotoxicity against human MIA PaCa-2 cells expressing CD73 assessed as reduction in cell viability by CCK8 assay
    		[PMID: 33359608]
    NCM460 IC50
    23 μg/mL
    Compound: PGG
    Antiproliferative activity against human NCM460 cells after 72 hrs by MTT assay
    Antiproliferative activity against human NCM460 cells after 72 hrs by MTT assay
    		[PMID: 22216935]
    TE-671 ED50
    > 10 μg/mL
    Compound: 10
    Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay
    Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay
    		[PMID: 1431932]
    體外研究
    (In Vitro)

    Pentagalloylglucose (1 μM, 5 天) 抑制乳腺癌細(xì)胞和髓母細(xì)胞瘤細(xì)胞的增殖和存活，IC50 分別為 3.24 μM 和 1.47 μM[1]。
    Pentagalloylglucose (10-20 μM, 24 h) 通過(guò)激活系膜細(xì)胞中的 Nrf2/HO-1 和抑制 JAK2/STAT3 途徑減少 AGE 誘導(dǎo)的炎癥[2]。
    Pentagalloylglucose (40 μM, 24 h) 通過(guò) GSK3β/β-catenin 途徑抑制人鼻咽癌細(xì)胞的生長(zhǎng)遷移，并阻滯細(xì)胞周期，誘導(dǎo)細(xì)胞凋亡自噬[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1].

    Cell Line: MDA-MB-231, DAOY, PC-3, SK-HEP-1 cells
    Concentration: 1 μM
    Incubation Time: 5 days