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  2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. Nucleoside Antimetabolite/Analog Endogenous Metabolite
  4. Orotic acid zinc

Orotic acid zinc  (Synonyms: 6-Carboxyuracil zinc; Vitamin B13 zinc)

目錄號: HY-N0157A 純度: 99.84%
COA 產(chǎn)品使用指南 技術(shù)支持

Orotic acid (zinc)，一種嘧啶核苷酸和 RNA 生物合成的前體，從線粒體二氫乳清酸脫氫酶 (DHODH) 中釋放，通過細(xì)胞質(zhì) UMP 合酶轉(zhuǎn)化為 UMP。Orotic acid (zinc) 是尿素循環(huán)異常的常規(guī)新生兒篩查中的測量指標(biāo)。Orotic acid (zinc) 可引起大鼠肝脂肪變性和肝腫大。

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Orotic acid zinc Chemical Structure

Orotic acid zinc Chemical Structure

CAS No. : 68399-76-8

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規(guī)格 價(jià)格 是否有貨 數(shù)量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mg ￥144
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25 mg ￥211
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50 mg ￥291
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100 mg ￥400
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200 mg ￥561
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500 mg ￥837
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1 g ￥1234
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Customer Review

Other Forms of Orotic acid zinc:

MCE 顧客使用本產(chǎn)品發(fā)表的 2 篇科研文獻(xiàn)

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Orotic acid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid (zinc) can induce hepatic steatosis and hepatomegaly in rats[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

體外研究
(In Vitro)

Orotic acid is found in milk and dairy products, and it is converted to uridine for use in the pyrimidine salvage pathway predominantly in liver, kidney and erythrocytes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Orotic acid is a marker for measurement of urea cycle disorders (UCDs), including ornithine transcarbamylase deficiency (OTCD)[2].
Orotic acid (1.0% addition to the diet; p.o. for 3-10 d) induces a development of fatty liver by day 7, and decreases purine/pyrimidine ratio of hepatic acid-soluble nucleotides by day 3[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

188.79

Formula

C5H4N2O4Zn0.5
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

乳清酸鋅；乳清酸鋅二水合物
結(jié)構(gòu)分類
初始來源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 20 mg/mL (105.94 mM; ultrasonic and adjust pH to 2 with 1 M HCL; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 5.2969 mL 26.4845 mL 52.9689 mL
5 mM 1.0594 mL 5.2969 mL 10.5938 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時(shí)，請?jiān)?個月內(nèi)使用，-20°C儲存時(shí)，請?jiān)?個月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計(jì)算器
請輸入動物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實(shí)驗(yàn)過程有損耗，建議您多配一只動物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時(shí)，請?jiān)?個月內(nèi)使用，-20°C儲存時(shí)，請?jiān)?個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.2969 mL 26.4845 mL 52.9689 mL 132.4223 mL
5 mM 1.0594 mL 5.2969 mL 10.5938 mL 26.4845 mL
10 mM 0.5297 mL 2.6484 mL 5.2969 mL 13.2422 mL
15 mM 0.3531 mL 1.7656 mL 3.5313 mL 8.8282 mL
20 mM 0.2648 mL 1.3242 mL 2.6484 mL 6.6211 mL
25 mM 0.2119 mL 1.0594 mL 2.1188 mL 5.2969 mL
30 mM 0.1766 mL 0.8828 mL 1.7656 mL 4.4141 mL
40 mM 0.1324 mL 0.6621 mL 1.3242 mL 3.3106 mL
50 mM 0.1059 mL 0.5297 mL 1.0594 mL 2.6484 mL
60 mM 0.0883 mL 0.4414 mL 0.8828 mL 2.2070 mL
80 mM 0.0662 mL 0.3311 mL 0.6621 mL 1.6553 mL
100 mM 0.0530 mL 0.2648 mL 0.5297 mL 1.3242 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Orotic acid zinc
目錄號：
HY-N0157A
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