(S)-10-Hydroxycamptothecin (Synonyms: 10-羥基喜樹堿; 10-HCPT; 10-Hydroxycamptothecin)

目錄號: HY-N0095 純度: 99.38%: FAQs
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(S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) 是一種從喜樹中分離的 DNA 拓?fù)洚悩?gòu)酶 I (DNA topoisomerase I) 抑制劑。(S)-10-Hydroxycamptothecin 可顯著誘導(dǎo)細(xì)胞凋亡，并可用于肝癌，胃癌，結(jié)腸癌和白血病的研究。

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(S)-10-Hydroxycamptothecin Chemical Structure

CAS No. : 19685-09-7

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規(guī)格	價(jià)格	是否有貨
10 mM * 1 mL in DMSO	￥462	In-stock
25 mg	￥420	In-stock
50 mg	￥600	In-stock
100 mg	￥950	In-stock
500 mg	￥2413	In-stock
1 g		詢價(jià)
5 g		詢價(jià)

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Other Forms of (S)-10-Hydroxycamptothecin:

(±)-10-Hydroxycamptothecin In-stock
(S)-10-Hydroxycamptothecin-d5 詢價(jià)
(S)-10-Hydroxycamptothecin (Standard) 詢價(jià)

(S)-10-Hydroxycamptothecin 相關(guān)產(chǎn)品

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Topoisomerase Topo I Topo II

生物活性
純度 & 產(chǎn)品資料
參考文獻(xiàn)

生物活性

(S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment^[1]^[2]^[3]^[4].

IC₅₀ & Target^[1]^[3]

Topoisomerase I

細(xì)胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A2780	IC₅₀	0.004 μM Compound: 2	Cytotoxicity against human A2780 cells overexpressing alpha5beta3 integrin assessed as cell survival after 72 hrs by SRB assay Cytotoxicity against human A2780 cells overexpressing alpha5beta3 integrin assessed as cell survival after 72 hrs by SRB assay	[PMID: 22959246]
A2780	IC₅₀	0.7 μM Compound: 2, HCPT	Cytotoxicity against human A2780 cells after 48 hrs by MTT assay Cytotoxicity against human A2780 cells after 48 hrs by MTT assay	[PMID: 19715319]
A-375	IC₅₀	0.15 μM Compound: HCPT	Cytotoxicity against human A375 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human A375 cells after 72 hrs by sulforhodamine B assay	[PMID: 23639650]
A-375	IC₅₀	27.8 μM Compound: HCPT	Cytotoxicity against human A375 cells after 72 hrs by MTT assay Cytotoxicity against human A375 cells after 72 hrs by MTT assay	[PMID: 26280921]
A-375	IC₅₀	27.8 μM Compound: HCPT	Cytotoxicity against human A375 cells after 72 hrs by MTT assay Cytotoxicity against human A375 cells after 72 hrs by MTT assay	[PMID: 25874331]
A549	IC₅₀	0.07 μM Compound: 10-OH CPT	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 23566520]
A549	IC₅₀	0.08 μM Compound: 10-HCPT	Cytotoxicity against human A549 assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against human A549 assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 32650182]
A549	IC₅₀	0.082 μM Compound: HCPT	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 26725027]
A549	IC₅₀	0.11 μM Compound: 6, CPT-OH	Antitumor activity against human A549/ATCC cells by SRB method Antitumor activity against human A549/ATCC cells by SRB method	[PMID: 19541483]
A549	IC₅₀	0.3 μM Compound: HCPT	Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay	[PMID: 23639650]
A549	IC₅₀	0.8 μM Compound: HCPT	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 28441581]
A549	IC₅₀	0.8 μM Compound: HCPT	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 27836197]
A549	IC₅₀	1.75 μM Compound: HCPT	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 29921475]
A549	IC₅₀	2.75 μM Compound: HCPT	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 30108853]
A549	IC₅₀	33.6 nM Compound: 10-HCPT	Cytotoxicity against human A549 after 72 hrs by SRB assay Cytotoxicity against human A549 after 72 hrs by SRB assay	[PMID: 22647222]
A549	IC₅₀	9.13 μM Compound: HCPT	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 30528976]
Bcap37	IC₅₀	> 20 μM Compound: HCPT	Antiproliferative activity against human Bcap37 cells after 72 hrs by MTT assay Antiproliferative activity against human Bcap37 cells after 72 hrs by MTT assay	[PMID: 23124210]
Bcap37	IC₅₀	28.1 μM Compound: HCPT	Cytotoxicity against human Bcap37 cells after 72 hrs by MTT assay Cytotoxicity against human Bcap37 cells after 72 hrs by MTT assay	[PMID: 26280921]
Bcap37	IC₅₀	28.1 μM Compound: HCPT	Cytotoxicity against human Bcap37 cells after 72 hrs by MTT assay Cytotoxicity against human Bcap37 cells after 72 hrs by MTT assay	[PMID: 25874331]
Bel-7402	IC₅₀	0.2 μM Compound: 2, HCPT	Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay	[PMID: 19715319]
Bel-7402	IC₅₀	0.2 μM Compound: 10-OH CPT	Cytotoxicity against human Bel7402 cells by MTT assay Cytotoxicity against human Bel7402 cells by MTT assay	[PMID: 23566520]
Bel-7402	IC₅₀	0.28 μM Compound: HCP	Cytotoxicity against human Bel-7402 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human Bel-7402 cells after 72 hrs by sulforhodamine B assay	[PMID: 17067169]
Bel-7402	IC₅₀	0.36 μM Compound: HCP	Cytotoxicity against human Bel7402 cells after 72 hrs by SRB assay Cytotoxicity against human Bel7402 cells after 72 hrs by SRB assay	[PMID: 20184290]
Bel-7402	IC₅₀	0.4 μM Compound: HCP	Cytotoxicity against human Bel7402 cells after 72 hrs by SRB assay Cytotoxicity against human Bel7402 cells after 72 hrs by SRB assay	[PMID: 19133759]
CNE-2	IC₅₀	0.37 μM Compound: HCPT	Cytotoxicity against human CNE2 cells after 48 hrs by MTT assay Cytotoxicity against human CNE2 cells after 48 hrs by MTT assay	[PMID: 19423199]
CNE-2	IC₅₀	1.04 μM Compound: 10-HCT	Antitumor against human CNE2 cells assessed as cell survival after 48 hrs by MTT assay Antitumor against human CNE2 cells assessed as cell survival after 48 hrs by MTT assay	[PMID: 21600681]
COLO 205	IC₅₀	9.1 nM Compound: 2	Cytotoxicity against human Colo 205 cells assessed as inhibition of [3H]thymidine after 48 hrs Cytotoxicity against human Colo 205 cells assessed as inhibition of [3H]thymidine after 48 hrs	[PMID: 18318465]
HCT-116	IC₅₀	0.021 μM Compound: 10-HCPT	Cytotoxicity against human HCT-116 assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against human HCT-116 assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 32650182]
HCT-116	IC₅₀	0.05 μM Compound: 10-HCPT	Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by CCK-8 assay Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by CCK-8 assay	[PMID: 35561631]
HCT-116	IC₅₀	0.3 μM Compound: 10-OH CPT	Cytotoxicity against human HCT116 cells by MTT assay Cytotoxicity against human HCT116 cells by MTT assay	[PMID: 23566520]
HCT-116	IC₅₀	3.2 μM Compound: HCPT	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 28441581]
HCT-116	IC₅₀	3.5 μM Compound: HCPT	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 27836197]
HCT-116	IC₅₀	31.2 nM Compound: 10-HCPT	Cytotoxicity against human HCT116 after 72 hrs by SRB assay Cytotoxicity against human HCT116 after 72 hrs by SRB assay	[PMID: 22647222]
HCT-116	IC₅₀	58.62 μM Compound: HCPT	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 26725027]
HCT-8	IC₅₀	0.181 μM Compound: 2	Antiproliferative activity against human HCT8 cells after 48 hrs by CCK8 assay Antiproliferative activity against human HCT8 cells after 48 hrs by CCK8 assay	[PMID: 25481395]
HeLa	IC₅₀	0.06 μM Compound: 10-HCPT	Antiproliferative activity against human HeLa cells incubated for 24 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells incubated for 24 hrs by CCK-8 assay	[PMID: 35561631]
HeLa	IC₅₀	10.04 μM Compound: HCPT	Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 48 hrs by MTT assay	[PMID: 28318943]
HeLa	IC₅₀	29.16 μM Compound: HCPT	Antiproliferative activity against human HeLa cells by MTT assay Antiproliferative activity against human HeLa cells by MTT assay	[PMID: 28745887]
HepG2	IC₅₀	0.499 μM Compound: 2	Antiproliferative activity against human HepG2 cells after 48 hrs by CCK8 assay Antiproliferative activity against human HepG2 cells after 48 hrs by CCK8 assay	[PMID: 25481395]
HepG2	IC₅₀	0.981 μM Compound: 10-Hydroxy CPT	Antitumor activity against human HepG2 cells by WST-1 assay Antitumor activity against human HepG2 cells by WST-1 assay	[PMID: 21414778]
HepG2	IC₅₀	1.47 μM Compound: HCPT	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 30600208]
HepG2	IC₅₀	10.1 μM Compound: HCPT	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 27836197]
HepG2	IC₅₀	10.21 μM Compound: HCPT	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 30528976]
HepG2	IC₅₀	10.3 μM Compound: HCPT	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 28441581]
HepG2	IC₅₀	2.27 μM Compound: HCPT	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 26725027]
HepG2	IC₅₀	3.19 μM Compound: HCPT	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 29921475]
HepG2	IC₅₀	3.7 μM Compound: 10-Hydroxycamptothecin	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 20402524]
HepG2	IC₅₀	5.4 nM Compound: 2	Cytotoxicity against human HepG2 cells assessed as inhibition of [3H]thymidine after 48 hrs Cytotoxicity against human HepG2 cells assessed as inhibition of [3H]thymidine after 48 hrs	[PMID: 18318465]
HepG2	IC₅₀	5.52 μM Compound: HCPT	Antiproliferative activity against human HepG2 cells by MTT assay Antiproliferative activity against human HepG2 cells by MTT assay	[PMID: 28745887]
HepG2	IC₅₀	6.49 μM Compound: 10-hydroxy-camptothecin	Cytotoxicity against human Hep G2 after 48 hrs by MTT assay Cytotoxicity against human Hep G2 after 48 hrs by MTT assay	[PMID: 16933867]
HL-60	IC₅₀	0.04 μM Compound: 10-Hydroxycamptothecin	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 20402524]
HL-60	IC₅₀	0.11 μM Compound: 5ak	Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells	[PMID: 8410981]
HL-60	IC₅₀	0.25 μM Compound: HCPT	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 23639650]
HL-60	IC₅₀	0.41 μM Compound: HCP	Cytotoxicity against human HL-60 cells after 72 hrs by MTT assay Cytotoxicity against human HL-60 cells after 72 hrs by MTT assay	[PMID: 17067169]
HT-29	IC₅₀	0.21 μM Compound: 6, CPT-OH	Antitumor activity against human HT-29 cells by SRB method Antitumor activity against human HT-29 cells by SRB method	[PMID: 19541483]
HT-29	IC₅₀	8.8 nM Compound: 2	Cytotoxicity against human HT29 cells assessed as inhibition of [3H]thymidine after 48 hrs Cytotoxicity against human HT29 cells assessed as inhibition of [3H]thymidine after 48 hrs	[PMID: 18318465]
HUVEC	IC₅₀	18.2 μM Compound: HCPT	Antiproliferative activity against human HUVEC cells after 48 hrs by MTT assay Antiproliferative activity against human HUVEC cells after 48 hrs by MTT assay	[PMID: 28441581]
Jurkat	IC₅₀	0.03 μM Compound: 10-Hydroxycamptothecin	Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay	[PMID: 20402524]
K562	IC₅₀	0.16 μM Compound: HCP	Cytotoxicity against human K562 cells after 72 hrs by MTT assay Cytotoxicity against human K562 cells after 72 hrs by MTT assay	[PMID: 20184290]
K562	IC₅₀	4.1 μM Compound: HCP	Cytotoxicity against human K562 cells after 72 hrs by MTT assay Cytotoxicity against human K562 cells after 72 hrs by MTT assay	[PMID: 19133759]
KB	IC₅₀	0.128 μM Compound: 2	Antiproliferative activity against human KB cells after 48 hrs by CCK8 assay Antiproliferative activity against human KB cells after 48 hrs by CCK8 assay	[PMID: 25481395]
KB	IC₅₀	0.6 μM Compound: 2, HCPT	Cytotoxicity against human KB cells after 48 hrs by MTT assay Cytotoxicity against human KB cells after 48 hrs by MTT assay	[PMID: 19715319]
KB	IC₅₀	0.6 μM Compound: 10-OH CPT	Cytotoxicity against human KB cells by MTT assay Cytotoxicity against human KB cells by MTT assay	[PMID: 23566520]
KB	IC₅₀	0.829 μM Compound: 10-Hydroxy CPT	Antitumor activity against human KB cells by WST-1 assay Antitumor activity against human KB cells by WST-1 assay	[PMID: 21414778]
L02	IC₅₀	10.23 μM Compound: HCPT	Antiproliferative activity against human HL-7702 cells after 48 hrs by MTT assay Antiproliferative activity against human HL-7702 cells after 48 hrs by MTT assay	[PMID: 30528976]
L02	IC₅₀	12.83 μM Compound: HCPT	Cytotoxicity against human HL7702 cells after 48 hrs by MTT assay Cytotoxicity against human HL7702 cells after 48 hrs by MTT assay	[PMID: 30108853]
L02	IC₅₀	20.4 μM Compound: HCPT	Antiproliferative activity against human L02 cells after 48 hrs by MTT assay Antiproliferative activity against human L02 cells after 48 hrs by MTT assay	[PMID: 28441581]
LoVo	IC₅₀	0.33 μM Compound: 10-HCPT	Cytotoxicity against human LoVo assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against human LoVo assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 32650182]
MCF7	IC₅₀	19.12 μM Compound: 10-hydroxy-camptothecin	Cytotoxicity against human MCF7 after 48 hrs by MTT assay Cytotoxicity against human MCF7 after 48 hrs by MTT assay	[PMID: 16933867]
MCF7	IC₅₀	2.4 μM Compound: HCPT	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 27836197]
MCF7	IC₅₀	2.8 μM Compound: HCPT	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 28441581]
MCF7	IC₅₀	3.58 μM Compound: HCPT	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 30600208]
MCF7	IC₅₀	48.2 μM Compound: HCPT	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 26280921]
MCF7	IC₅₀	48.2 μM Compound: HCPT	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 25874331]
MDA-MB-231	IC₅₀	0.06 μM Compound: 10-OH CPT	Cytotoxicity against human MDA-MB-231 cells by MTT assay Cytotoxicity against human MDA-MB-231 cells by MTT assay	[PMID: 23566520]
MG-63	IC₅₀	10.69 μM Compound: HCPT	Antiproliferative activity against human MG63 cells after 48 hrs by MTT assay Antiproliferative activity against human MG63 cells after 48 hrs by MTT assay	[PMID: 30528976]
MGC-803	IC₅₀	> 20 μM Compound: HCPT	Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay	[PMID: 23124210]
MGC-803	IC₅₀	15.19 μM Compound: HCPT	Antiproliferative activity against human MGC803 cells by MTT assay Antiproliferative activity against human MGC803 cells by MTT assay	[PMID: 28745887]
MGC-803	IC₅₀	29.1 μM Compound: HCPT	Cytotoxicity against human MGC803 cells after 72 hrs by MTT assay Cytotoxicity against human MGC803 cells after 72 hrs by MTT assay	[PMID: 26280921]
MGC-803	IC₅₀	29.1 μM Compound: HCPT	Cytotoxicity against human MGC803 cells after 72 hrs by MTT assay Cytotoxicity against human MGC803 cells after 72 hrs by MTT assay	[PMID: 25874331]
MGC-803	IC₅₀	6.55 μM Compound: HCPT	Cytotoxicity against human MGC803 cells after 48 hrs by MTT assay Cytotoxicity against human MGC803 cells after 48 hrs by MTT assay	[PMID: 30108853]
MGC-803	IC₅₀	6.55 μM Compound: HCPT	Cytotoxicity against human MGC803 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human MGC803 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 29921475]
MGC-803	IC₅₀	9.71 μM Compound: HCPT	Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay	[PMID: 30528976]
NCI-H460	IC₅₀	10.08 μM Compound: HCPT	Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells after 48 hrs by MTT assay	[PMID: 30528976]
NCI-H460	IC₅₀	16.59 μM Compound: HCPT	Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay	[PMID: 30108853]
NCI-H460	IC₅₀	38.55 μM Compound: 10-hydroxy-camptothecin	Cytotoxicity against human NCI-H460 after 48 hrs by MTT assay Cytotoxicity against human NCI-H460 after 48 hrs by MTT assay	[PMID: 16933867]
NCI-H460	IC₅₀	4.91 μM Compound: HCPT	Antiproliferative activity against human NCI-H460 cells by MTT assay Antiproliferative activity against human NCI-H460 cells by MTT assay	[PMID: 28745887]
PC-3	IC₅₀	0.078 μM Compound: 2	Cytotoxicity against human PC3 cells expressing alpha5beta3 integrin assessed as cell survival after 72 hrs by SRB assay Cytotoxicity against human PC3 cells expressing alpha5beta3 integrin assessed as cell survival after 72 hrs by SRB assay	[PMID: 22959246]
PC-3	IC₅₀	34.5 μM Compound: HCPT	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	[PMID: 26280921]
PC-3	IC₅₀	34.5 μM Compound: HCPT	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	[PMID: 25874331]
SF-268	IC₅₀	29.88 μM Compound: 10-hydroxy-camptothecin	Cytotoxicity against human SF-268 after 48 hrs by MTT assay Cytotoxicity against human SF-268 after 48 hrs by MTT assay	[PMID: 16933867]
SGC-7901	IC₅₀	0.835 μM Compound: 2	Antiproliferative activity against human SGC7901 cells after 48 hrs by CCK8 assay Antiproliferative activity against human SGC7901 cells after 48 hrs by CCK8 assay	[PMID: 25481395]
SMMC-7721	IC₅₀	0.14 μM Compound: HCP	Growth inhibition of human SMMC7721 cells after 48 hrs by MTT assay Growth inhibition of human SMMC7721 cells after 48 hrs by MTT assay	[PMID: 19842682]
T-24	IC₅₀	11.83 μM Compound: HCPT	Cytotoxicity against human T24 cells after 48 hrs by MTT assay Cytotoxicity against human T24 cells after 48 hrs by MTT assay	[PMID: 30108853]
T-24	IC₅₀	11.83 μM Compound: HCPT	Cytotoxicity against human T24 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human T24 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 29921475]
T-24	IC₅₀	5.53 μM Compound: HCPT	Antiproliferative activity against human T24 cells by MTT assay Antiproliferative activity against human T24 cells by MTT assay	[PMID: 28745887]
U-937	IC₅₀	0.11 μM Compound: 10-Hydroxycamptothecin	Cytotoxicity against human U937 cells after 48 hrs by MTT assay Cytotoxicity against human U937 cells after 48 hrs by MTT assay	[PMID: 20402524]

體外研究
(In Vitro)

(S)-10-Hydroxycamptothecin (5-20 μg/L; 6 days; Hep G2 cells) treatment results in the cell cycle arrest at G2/M phase^[2].
(S)-10-Hydroxycamptothecin induces differentiation, down-regulates nuclear antigen (PCNA) and up-regulates wild-type protein p53 in Hep G2 cells^[2].
(S)-10-Hydroxycamptothecin inhibits L1210 leukemia cells with an IC₅₀ of 1.15 μM^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[2]

Cell Line:	Hep G2 cells
Concentration:	5 μg/L, 10 μg/L, 20 μg/L
Incubation Time:	6 days
Result:	Hep G2 cells were mainly arrested at G2/M phase.

體內(nèi)研究
(In Vivo)

(S)-10-Hydroxycamptothecin (10-Hydroxycamptothecin) against L1210 leukemia in mice is tested. At the optimal dose (15 mg/kg), (S)-10-Hydroxycamptothecin has a 71% increase in life span (ILS)^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

364.35

Formula

C₂₀H₁₆N₂O₅

CAS 號

19685-09-7

性狀

固體

顏色

Light yellow to yellow

中文名稱

伊立替康EP雜質(zhì)B (10-Hydroxy Camptothecin)

結(jié)構(gòu)分類

初始來源

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)

細(xì)胞實(shí)驗(yàn)：

DMSO 中的溶解度 : 50 mg/mL (137.23 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液

濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg

1 mM	2.7446 mL	13.7231 mL	27.4461 mL
5 mM	0.5489 mL	2.7446 mL	5.4892 mL
10 mM	0.2745 mL	1.3723 mL	2.7446 mL

查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用，-20°C儲存時(shí)，請?jiān)?個(gè)月內(nèi)使用。

摩爾計(jì)算器
稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

濃度 _(start)

體積 _(start)

濃度 _(final)

體積 _(final)

動(dòng)物實(shí)驗(yàn)：

請根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥方式選擇適當(dāng)?shù)娜芙夥桨浮?

以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

方案一

請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (6.86 mM); 懸濁液; 超聲助溶

此方案可獲得 2.5 mg/mL的均勻懸濁液，懸濁液可用于口服和腹腔注射。
以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水定容至 1 mL。
生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
方案二

請依序添加每種溶劑： 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (6.86 mM); 懸濁液; 超聲助溶

此方案可獲得 2.5 mg/mL的均勻懸濁液，懸濁液可用于口服和腹腔注射。
以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液中，混合均勻。
2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。

動(dòng)物溶解方案計(jì)算器

請輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只

由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量

請輸入您的動(dòng)物體內(nèi)配方組成：

DMSO +

Tween-80 +

Saline

如果您的動(dòng)物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。

方案所需 助溶劑 包括：DMSO，，均可在 MCE 網(wǎng)站選購。，Tween 80，均可在 MCE 網(wǎng)站選購。

計(jì)算結(jié)果

工作液所需濃度 : mg/mL

儲備液配制方法 : mg 藥物溶于 μL DMSO（母液濃度為 mg/mL）。

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

您所需的儲備液濃度超過該產(chǎn)品的實(shí)測溶解度，以下方案僅供參考，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。

動(dòng)物實(shí)驗(yàn)體內(nèi)工作液的配制方法 : 取 μL DMSO 儲備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。

連續(xù)給藥周期超過半月以上，請謹(jǐn)慎選擇該方案。

請確保第一步儲備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱（超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。

純度 & 產(chǎn)品資料

純度: 99.38%

選擇批次：

Data Sheet (626 KB) SDS (393 KB)

COA (292 KB) HNMR (171 KB) LCMS (584 KB)

產(chǎn)品使用指南 (1538 KB)

參考文獻(xiàn)

[1]. Min Liu, et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance . Journal of Drug Targeting.

[2]. Min Liu, et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance. J Drug Target, Early Online: 1–8

[3]. Yu P, et al. Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs. Biol Pharm Bull. 2012;35(8):1295-9. [Content Brief]

[4]. Zhang XW, et al. Differentiation-inducing action of 10-hydroxycamptothecin on human hepatoma Hep G2 cells. Acta Pharmacol Sin. 2000 Apr;21(4):364-8. [Content Brief]

[5]. Zhang XW, et al. Differential regulation of P53, c-Myc, Bcl-2, Bax and AFP protein expression, and caspase activity during 10-hydroxycamptothecin-induced apoptosis in Hep G2 cells. Anticancer Drugs. 2000 Oct;11(9):747-56. [Content Brief]

[6]. Liu M, et al. Intracellular delivery of 10-hydroxycamptothecin with targeted nanostructured lipid carriers against multidrug resistance. J Drug Target. 2016;24(5):433-40. [Content Brief]

(S)-10-Hydroxycamptothecin 相關(guān)分類

完整儲備液配制表

可選溶劑	濃度溶劑體積質(zhì)量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7446 mL	13.7231 mL	27.4461 mL	68.6153 mL
	5 mM	0.5489 mL	2.7446 mL	5.4892 mL	13.7231 mL
	10 mM	0.2745 mL	1.3723 mL	2.7446 mL	6.8615 mL
	15 mM	0.1830 mL	0.9149 mL	1.8297 mL	4.5744 mL
	20 mM	0.1372 mL	0.6862 mL	1.3723 mL	3.4308 mL
	25 mM	0.1098 mL	0.5489 mL	1.0978 mL	2.7446 mL
	30 mM	0.0915 mL	0.4574 mL	0.9149 mL	2.2872 mL
	40 mM	0.0686 mL	0.3431 mL	0.6862 mL	1.7154 mL
	50 mM	0.0549 mL	0.2745 mL	0.5489 mL	1.3723 mL
	60 mM	0.0457 mL	0.2287 mL	0.4574 mL	1.1436 mL
	80 mM	0.0343 mL	0.1715 mL	0.3431 mL	0.8577 mL
	100 mM	0.0274 mL	0.1372 mL	0.2745 mL	0.6862 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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(S)-10-Hydroxycamptothecin (Synonyms: 10-羥基喜樹堿; 10-HCPT; 10-Hydroxycamptothecin)

Other Forms of (S)-10-Hydroxycamptothecin:

(S)-10-Hydroxycamptothecin 相關(guān)產(chǎn)品

•相關(guān)化合物庫:

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生物活性

純度 & 產(chǎn)品資料

參考文獻(xiàn)

摩爾計(jì)算器

稀釋計(jì)算器

(S)-10-Hydroxycamptothecin 相關(guān)分類

完整儲備液配制表

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(S)-10-Hydroxycamptothecin (Synonyms: 10-羥基喜樹堿; 10-HCPT; 10-Hydroxycamptothecin)

Other Forms of (S)-10-Hydroxycamptothecin:

(S)-10-Hydroxycamptothecin 相關(guān)抗體

(S)-10-Hydroxycamptothecin 相關(guān)產(chǎn)品

•相關(guān)化合物庫:

•同靶點(diǎn)產(chǎn)品:

•同靶點(diǎn)蛋白產(chǎn)品:

查看 Topoisomerase 亞型特異性產(chǎn)品:

生物活性

純度 & 產(chǎn)品資料

參考文獻(xiàn)

(S)-10-Hydroxycamptothecin 相關(guān)抗體:

摩爾計(jì)算器

稀釋計(jì)算器

(S)-10-Hydroxycamptothecin 相關(guān)分類

完整儲備液配制表

Keywords:

您最近查看的產(chǎn)品:

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