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  2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. β-Nicotinamide mononucleotide

β-Nicotinamide mononucleotide  (Synonyms: 煙酰胺單核苷酸; β-NM; NMN)

目錄號: HY-F0004 純度: 99.90%
COA 產(chǎn)品使用指南 技術(shù)支持

β-nicotinamide mononucleotide (β-NM) 是煙酰胺磷酸核糖轉(zhuǎn)移酶 (NAMPT) 反應的產(chǎn)物，NAD+ 的關(guān)鍵中間體。β-nicotinamide mononucleotide 的作用包括其在細胞生化功能、心臟保護、糖尿病、阿爾茨海默病和肥胖相關(guān)并發(fā)癥中的作用。

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β-Nicotinamide mononucleotide Chemical Structure

β-Nicotinamide mononucleotide Chemical Structure

CAS No. : 1094-61-7

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in Water ￥343
In-stock
5 mg ￥312
In-stock
10 mg ￥491
In-stock
25 mg ￥811
In-stock
50 mg ￥1135
In-stock
100 mg ￥1589
In-stock
500 mg ￥4600
In-stock
1 g 現(xiàn)貨 詢價
5 g   詢價  
10 g   詢價  

* Please select Quantity before adding items.

Other Forms of β-Nicotinamide mononucleotide:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

β-nicotinamide mononucleotide (β-NM) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD+ intermediate. The pharmacological activities of β-nicotinamide mononucleotide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity[1].

IC50 & Target

Human Endogenous Metabolite

 

體外研究
(In Vitro)

β-nicotinamide mononucleotide has several beneficial pharmacological activities. Mostly mediated by its involvement in NAD+ biosynthesis, the pharmacological activities of NMN include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity[1].
The intracellular NAD+ levels are significantly decreased by knockdown or knockout of Nampt (Nampt KD or Nampt KO) or treatment with Nampt inhibitor FK866, whereas NAD+ levels are dramatically increased by supplement of NAD+ precursors NAM or NMN (0.5-1 mM). NAD+ precursor NMN treatment inhibited CD8+ T cells activation and function[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

β-Nicotinamide mononucleotide (500 mg/kg; i.p.; 3 times per week for 7-10 week) prevents mtDNA damage and Dox-induced cardiac dysfunction[3].
Nampt KO markedly inhibits tumor progression, whereas Nampt metabolite β-Nicotinamide mononucleotide (300 mg/kg body weight; i.p.; once every two days for 2 weeks) significantly promotes tumor growth in C57BL/6 mice (bearing wildtype Hepa1-6 cells). The reduction and increase in NAD+ level of respective Nampt KO and β-Nicotinamide mononucleotide-treated tumors are confirmed[2].
β-nicotinamide mononucleotide ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. β-nicotinamide mononucleotide also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL6 mice (p53?/? mice)[3]
Dosage: 500 mg/kg
Administration: I.p.; 3 times per week for 7-10 week
Result: Prevented the significant decline in cardiac function of Dox-treated p53?/? mice (study week 7 versus 10) along with rescuing the decreased mitochondrial respiration and tissue ATP depletion caused by Doxorubicin (Dox).
分子量

334.22

Formula

C11H15N2O8P
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

β-煙酰胺單核苷酸；煙酰胺單核苷酸
結(jié)構(gòu)分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)
細胞實驗： 

H2O 中的溶解度 : 83.33 mg/mL (249.33 mM; 超聲助溶)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.9920 mL 14.9602 mL 29.9204 mL
5 mM 0.5984 mL 2.9920 mL 5.9841 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物實驗：

以下溶解方案，請直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

  • 方案 一

    請依序添加每種溶劑： PBS

    Solubility: 100 mg/mL (299.20 mM); 澄清溶液; 超聲助溶

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
該產(chǎn)品水溶性佳，請具體參考實測 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料

純度: 99.90%

參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.9920 mL 14.9602 mL 29.9204 mL 74.8010 mL
5 mM 0.5984 mL 2.9920 mL 5.9841 mL 14.9602 mL
10 mM 0.2992 mL 1.4960 mL 2.9920 mL 7.4801 mL
15 mM 0.1995 mL 0.9973 mL 1.9947 mL 4.9867 mL
20 mM 0.1496 mL 0.7480 mL 1.4960 mL 3.7401 mL
25 mM 0.1197 mL 0.5984 mL 1.1968 mL 2.9920 mL
30 mM 0.0997 mL 0.4987 mL 0.9973 mL 2.4934 mL
40 mM 0.0748 mL 0.3740 mL 0.7480 mL 1.8700 mL
50 mM 0.0598 mL 0.2992 mL 0.5984 mL 1.4960 mL
60 mM 0.0499 mL 0.2493 mL 0.4987 mL 1.2467 mL
80 mM 0.0374 mL 0.1870 mL 0.3740 mL 0.9350 mL
100 mM 0.0299 mL 0.1496 mL 0.2992 mL 0.7480 mL

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
β-Nicotinamide mononucleotide
目錄號：
HY-F0004
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