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  2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Ser/Thr Protease Thrombopoietin Receptor
  4. Imidazole

Imidazole  (Synonyms: 咪唑; Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene)

目錄號: HY-D0837 純度: 99.94%
COA 產(chǎn)品使用指南

Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene)，一種雜環(huán)芳香族化合物。咪唑類分子已被用作緩蝕劑、乙酰膽堿酯酶（AChEI）和黃嘌呤氧化酶（XO）抑制劑，具有抗真菌、抗結(jié)核、抗炎、抗氧化、鎮(zhèn)痛等生物活性。咪唑抑制血小板微粒體將內(nèi)過氧化物(PGG2 和PGH2)轉(zhuǎn)化為血栓素A2。咪唑衍生物對 SARS-CoV-2 3ClPro 酶有抑制作用，有望用于阿爾茨海默病、痛風、新冠肺炎和血栓疾病領(lǐng)域的研究。

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Imidazole Chemical Structure

Imidazole Chemical Structure

CAS No. : 288-32-4

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥193
In-stock
5 g ￥175
In-stock
10 g   詢價  
50 g   詢價  

* Please select Quantity before adding items.

Other Forms of Imidazole:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease[1][2][3].
IC50 & Target

Human Endogenous Metabolite

 

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 20 μM
Compound: Imidazole
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
[PMID: 30822712]
A549 IC50
> 20 μM
Compound: Imidazole
Cytotoxicity against human A549 cells by MTT assay
Cytotoxicity against human A549 cells by MTT assay
[PMID: 26684853]
CHO IC50
3675 μM
Compound: 20
Cytotoxicity against CHO cells after 48 hrs by MTT assay
Cytotoxicity against CHO cells after 48 hrs by MTT assay
[PMID: 20634079]
HL-60 IC50
> 20 μM
Compound: Imidazole
Antiproliferative activity against human HL60 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Antiproliferative activity against human HL60 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
[PMID: 30822712]
HL-60 IC50
> 20 μM
Compound: Imidazole
Cytotoxicity against human HL60 cells by MTT assay
Cytotoxicity against human HL60 cells by MTT assay
[PMID: 26684853]
MCF7 IC50
> 20 μM
Compound: Imidazole
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
[PMID: 30822712]
MCF7 IC50
> 20 μM
Compound: Imidazole
Cytotoxicity against human MCF7 cells by MTT assay
Cytotoxicity against human MCF7 cells by MTT assay
[PMID: 26684853]
SMMC-7721 IC50
> 20 μM
Compound: Imidazole
Antiproliferative activity against human SMMC7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Antiproliferative activity against human SMMC7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
[PMID: 30822712]
SMMC-7721 IC50
> 20 μM
Compound: Imidazole
Cytotoxicity against human SMMC7721 cells by MTT assay
Cytotoxicity against human SMMC7721 cells by MTT assay
[PMID: 26684853]
SW480 IC50
> 20 μM
Compound: Imidazole
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
[PMID: 30822712]
SW480 IC50
> 20 μM
Compound: Imidazole
Cytotoxicity against human SW480 cells by MTT assay
Cytotoxicity against human SW480 cells by MTT assay
[PMID: 26684853]
體外研究
(In Vitro)

Imidazole (0.01-100 μM, 48 h) 無抑制活性，但咪唑衍生物對不同腫瘤細胞系均有顯著抑制作用[1]。
Imidazole (0.01-100 μM, 48 h) 對腫瘤細胞中 EGFR 和 HER2 均有較弱的親和力，而咪唑衍生物可提高其對腫瘤細胞中這些受體的親和力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: A549, HBL-100, HeLa, SW1573, T-47D, WiDr cell lines
Concentration: 0.01-100 μM
Incubation Time: 48 h
Result: Had no inhibitory activity in the compounds employed as control in different tumor cell lines.
體內(nèi)研究
(In Vivo)

Imidazole (50 pg/ml , 灌注) 和類似的化合物是內(nèi)過氧化物轉(zhuǎn)化為血栓素的選擇性抑制劑[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

68.08

Formula

C3H4N2
CAS 號
性狀

固體

顏色

Off-white to light brown

中文名稱

咪唑；異吡唑；間二氮茂
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細胞實驗： 

H2O 中的溶解度 : ≥ 100 mg/mL (1468.86 mM)

DMSO 中的溶解度 : 100 mg/mL (1468.86 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 14.6886 mL 73.4430 mL 146.8860 mL
5 mM 2.9377 mL 14.6886 mL 29.3772 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用，-20°C儲存時，請在1年內(nèi)使用。

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物實驗：

以下溶解方案，請直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

  • 方案 一

    請依序添加每種溶劑： PBS

    Solubility: 100 mg/mL (1468.86 mM); 澄清溶液; 超聲助溶

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
該產(chǎn)品水溶性佳，請具體參考實測 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料

純度: 99.94%

參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用，-20°C儲存時，請在1年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 14.6886 mL 73.4430 mL 146.8860 mL 367.2150 mL
5 mM 2.9377 mL 14.6886 mL 29.3772 mL 73.4430 mL
10 mM 1.4689 mL 7.3443 mL 14.6886 mL 36.7215 mL
15 mM 0.9792 mL 4.8962 mL 9.7924 mL 24.4810 mL
20 mM 0.7344 mL 3.6722 mL 7.3443 mL 18.3608 mL
25 mM 0.5875 mL 2.9377 mL 5.8754 mL 14.6886 mL
30 mM 0.4896 mL 2.4481 mL 4.8962 mL 12.2405 mL
40 mM 0.3672 mL 1.8361 mL 3.6722 mL 9.1804 mL
50 mM 0.2938 mL 1.4689 mL 2.9377 mL 7.3443 mL
60 mM 0.2448 mL 1.2241 mL 2.4481 mL 6.1203 mL
80 mM 0.1836 mL 0.9180 mL 1.8361 mL 4.5902 mL
100 mM 0.1469 mL 0.7344 mL 1.4689 mL 3.6722 mL

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

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Imidazole
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HY-D0837
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