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  4. PLGA (75:25)

PLGA (75:25)  (Synonyms: 乳酸/乙醇酸共聚物 (75:25); poly(lactic-co-glycolic acid) (75:25))

目錄號(hào): HY-B2247A 含量: 99.54%
COA 產(chǎn)品使用指南 技術(shù)支持

PLGA (75:25) 是一種低毒的，具有生物相容性和生物降解性的活性分子控釋載體，可在生物體內(nèi)達(dá)到緩釋的作用。PLGA (75:25) 由 75% 聚乳酸 (PLA) 和 25% 聚乙醇酸 (PGA) 的聚合而成。PLGA (75:25) 已被廣泛用于活性分子、蛋白質(zhì)和其他各種大分子如 DNA、RNA和肽的輸送研究。

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PLGA (75:25) Chemical Structure

PLGA (75:25) Chemical Structure

CAS No. : 34346-01-5

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規(guī)格 價(jià)格 是否有貨 數(shù)量
100 mg ￥500
In-stock
500 mg ￥1500
In-stock
1 g   詢價(jià)  
5 g   詢價(jià)  

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Customer Review

Other Forms of PLGA (75:25):

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

PLGA (75:25) is a low toxicity, biocompatible and biodegradable controlled drug delivery carrier, can achieve slow release in the organism. PLGA (75:25) is a copolymer of 75% poly lactic acid (PLA) and 25% poly glycolic acid (PGA). PLGA (75:25) has been extensively studied as delivery vehicles for agents, proteins and various other macromolecules such as DNA, RNA and peptides[1][2][3].

體外研究
(In Vitro)

PLGA 75:25 (0.03-5 mg/mL；72 小時(shí)) 僅在濃度過高而無法用于臨床時(shí)影響 Calu-3 細(xì)胞的活力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Calu-3 cells
Concentration: 0.03-5 mg/mL (for PLgA (75:25)/PVA and PLgA (75:25)/CS); 3-5 mg/mL (for PLgA (75:25)/CS and PLgA (75:25)/PF68); 0.03-1 mg/mL (for PLgA (75:25)/PVA and PLgA (75:25)/PF68) (CS (chitosan), PF68 and PVA (poly vinyl alcohol) serve as cationic stabilizer)
Incubation Time: 72 h
Result: Showed low toxicity to cells (cell viability was always higher than 50%) even at the highest concentration tested, when xposured to PLgA (75:25)/PVA, PLgA (75:25)/CS and PLgA (75:25)/PF68 nanoparticles.
Increased cell viability, after short exposure (4 hours) to PLGA/PF68 nanoparticles.
體內(nèi)研究
(In Vivo)

PLGA 75:25 (40 mg/kg Risperidone (PLGA 75:25 as a drug delivery carrier)；sc；single) 具有良好的45天緩釋活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[2].
Dosage: 40 mg/kg (dose of Risperidone, PLGA (75:25) as a drug delivery carrier).
Administration: Subcutaneous injection; single.
Result: Achieved slow release in vivo: after an initial burst, a sharp drop occurred and the drug levels through day 22 remained in a steady manner while progressing to a decline up to day 45.
CAS 號(hào)
性狀

固體

顏色

White to off-white

中文名稱

乳酸/乙醇酸共聚物 (75:25)
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 100 mg/mL (超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.54%

參考文獻(xiàn)
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
PLGA (75:25)
目錄號(hào)：
HY-B2247A
需求量：