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  2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Apoptosis HDAC
  4. Triacetin

Triacetin  (Synonyms: 三醋酸甘油酯; Glyceryl triacetate; 1,2,3-Triacetoxypropane)

目錄號: HY-B0896 純度: 99.58%
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Triacetin是一種人工合成的化合物，是甘油和乙酸的三酯。

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Triacetin Chemical Structure

Triacetin Chemical Structure

CAS No. : 102-76-1

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥110
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100 mg ￥100
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500 mg ￥150
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1 g ￥200
In-stock
5 g ￥320
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Other Forms of Triacetin:

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

Triacetin (Glyceryl triacetate) is a synthetic compound that is a triester of glycerol and acetic acid. Triacetin increases acetate bioavailability in glioma cells. Triacetin induces glioma cell growth arrest and Apoptosis. Triacetin freely crosses the blood brain barrier/plasma membrane. Triacetin increases histone acetylation and enhances Temozolomide (HY-17364) (TMZ) chemotherapeutic efficacy [1][2].

IC50 & Target

Human Endogenous Metabolite

 

體外研究
(In Vitro)

Triacetin (0.25%, 24 h) 在體外誘導 HOG, Hs683, U87, U251, OG33, OG35 GBM9, GBM12, GBM34, GBM2, GBM8 和 GBM44 細胞生長停滯[1]。
Triacetin (25 mM, 24 h) 可有效抑制 U87MG (人類惡性膠質瘤) 細胞活力[2]。
Triacetin (12.5-25 mM, 24 h) 在 U87MG 細胞中誘導明顯的 G2/M 細胞周期阻滯[2]。
Triacetin (12.5 mM) 誘導 GBM 癌癥細胞凋亡[2]。
Triacetin (25 mM, 24 h) 降低 U87MG 細胞中 I類 和 II 類 HDAC (組蛋白脫乙酰酶) mRNA 的表達[2]。
Triacetin (12.5 mM, 24 h) 抑制 U87MG 細胞中 HDAC-8 的活性[2]。
Triacetin (12.5 mM, 24 h) 激活 mTOR 復合物下游基因，這些基因在癌癥細胞代謝中起重要作用，如S6K1，mSIN1，Protor 2 和 PKCα[2]。
Triacetin (12.5 mM, 24 h) 促進有腫瘤抑制作用的 miRs 表達，這些 miRs 可以抑制 U87MG 細胞的生長，增殖，侵襲，遷移和血管生成[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Human malignant glioma (U87 MG) cells
Concentration: 25 mM
Incubation Time: 24 h
Result: Inhibited the U87MG cell viability.

Cell Cycle Analysis[1]

Cell Line: Established glioma cell lines and primary tumor-derived GSCs.
Concentration: 0.25%
Incubation Time: 24 h
Result: Induced G0 growth arrest of all glioma cells, except U87, U251 and GBM (glioblastoma) 8 GSCs, without affecting Oli-Neu OPCs (oligodendrocyte progenitor cell line) or astrocytes and promoted NSC (neural stem cells) expansion.
The growth reduction of established glioma cell lines and primary tumor-derived GSCs in vitro is not due to the promotion of differentiation.

Cell Cycle Analysis[2]

Cell Line: U87 MG cells
Concentration: 12.5, 25 mM
Incubation Time: 24 h
Result: Induced 12% and 25% of sub-G1 cells and 60% and 79% of G2/M cells.

Apoptosis Analysis[2]

Cell Line: GBM cancer cells
Concentration: 12.5 mM
Incubation Time: 24 h
Result: Increased caspase-3 activity in treated GBM cancer cells.

RT-PCR[2]

Cell Line: U87MG cells
Concentration: 25 mM
Incubation Time: 24 h
Result: Decreased the classI and class II HDAC (histone deacetylase) mRNA expression.
Increased expression of S6K1, mSIN1, Protor 2, and PKCα.
Increased expression of miR-15b, miR-92, miR-101, miR-155, miR-199, miR-200, miR-223, and slight increase in expression in miR-16 and miR-17.
體內研究
(In Vivo)

Triacetin (5.0 g/kg with 10% v/v oral-sweet SF, p.o., daily, 14 days) 可增強植入少突膠質瘤 GSCs 小鼠 TMZ (Temozolomide) (HY-17364) 化療療效[1]。
Triacetin (5.0 g/kg with 10% v/v Ora-Sweet SF, p.o., daily, 40days) 可提高原位植入 GBM GSCs 小鼠的存活率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult (8 week, 24 - 28g) male athymic mice orthotopically engrafted with oligodendroglioma-derived GSC cells [1].
Dosage: 5.0 g/kg with 10% v/v oral-sweet SF
Administration: p.o., daily, 14 days
Result: Significantly reduced tumor bioluminescence and increased survival but did not reduce end-point tumor volume with treatment of TMZ (Temozolomide) (HY-17364).
Animal Model: Adult (8 week, 24 - 28g) male athymic mice orthotopically engrafted with GBM-derived GSC cells[1].
Dosage: 5.0 g/kg with 10% v/v oral-sweet SF
Administration: p.o., daily, 40 days
Result: Alone did not alter blood glucose, bioluminescence, or end-point tumor volume; however, increased survival.
Significantly increased survival with treatment of TMZ, with two of eight mice never redeveloping measurable flux or displaying histological signs of tumor at study termination.
分子量

218.20

Formula

C9H14O6
CAS 號
性狀

液體（密度：1.16 g/cm3）

顏色

Colorless to light yellow

中文名稱

三醋精；三醋酸甘油酯；三醋汀；三乙酸丙酯；三乙酸甘油酯；甘油三乙酸酯
結構分類
初始來源
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : ≥ 2.3 mg/mL (10.54 mM; 吸濕的 DMSO 對產品的溶解度有顯著影響，請使用新開封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 4.5830 mL 22.9148 mL 45.8295 mL
5 mM 0.9166 mL 4.5830 mL 9.1659 mL
查看完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產品資料
參考文獻

完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.5830 mL 22.9148 mL 45.8295 mL 114.5738 mL
5 mM 0.9166 mL 4.5830 mL 9.1659 mL 22.9148 mL
10 mM 0.4583 mL 2.2915 mL 4.5830 mL 11.4574 mL
Help & FAQs
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Triacetin
目錄號：
HY-B0896
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