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  2. Anti-infection
  3. Parasite
  4. Eflornithine hydrochloride

Eflornithine hydrochloride  (Synonyms: 鹽酸依氟鳥氨酸；依氟鳥氨酸; DFMO hydrochloride; MDL71782 hydrochloride; RMI71782 hydrochloride; α-difluoromethylornithine hydrochloride)

目錄號: HY-B0744A 純度: ≥98.0%
COA 產(chǎn)品使用指南 技術(shù)支持

Eflornithine hydrochloride (DFMO hydrochloride) 是酶鳥氨酸脫羧酶的特異性不可逆抑制劑。Eflornithine hydrochloride (DFMO hydrochloride) 可用于非洲錐蟲病和女性面部毛發(fā)過度生長的研究。

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Eflornithine hydrochloride Chemical Structure

Eflornithine hydrochloride Chemical Structure

CAS No. : 68278-23-9

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Other Forms of Eflornithine hydrochloride:

  • 生物活性

  • 實驗參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Eflornithine hydrochloride is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

IC50 & Target

Trypanosoma

 

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
J774 IC50
> 1000 μM
Compound: S3
Cytotoxicity against J774.1 cell line after 48 hrs
Cytotoxicity against J774.1 cell line after 48 hrs
[PMID: 16516467]
體內(nèi)研究
(In Vivo)

Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[1]. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism[2]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles[3]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

218.63

Formula

C6H13ClF2N2O2
CAS 號
性狀

固體

顏色

White to light yellow

中文名稱

鹽酸依氟烏氨酸
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數(shù)據(jù)
細胞實驗： 

H2O 中的溶解度 : 100 mg/mL (457.39 mM; 超聲助溶)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 4.5739 mL 22.8697 mL 45.7394 mL
5 mM 0.9148 mL 4.5739 mL 9.1479 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
該產(chǎn)品水溶性佳，請具體參考實測 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻
Animal Administration
[3]

Mice: The skin area where the hair is removed is then treated with the eflornithine hydrochloride 13.9% cream (～50?mg per mouse per treatment) using a spatula 2 times a day in an interval of at least 8?h for a maximum period of 36?days[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻

Eflornithine hydrochloride 相關(guān)分類

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.5739 mL 22.8697 mL 45.7394 mL 114.3484 mL
5 mM 0.9148 mL 4.5739 mL 9.1479 mL 22.8697 mL
10 mM 0.4574 mL 2.2870 mL 4.5739 mL 11.4348 mL
15 mM 0.3049 mL 1.5246 mL 3.0493 mL 7.6232 mL
20 mM 0.2287 mL 1.1435 mL 2.2870 mL 5.7174 mL
25 mM 0.1830 mL 0.9148 mL 1.8296 mL 4.5739 mL
30 mM 0.1525 mL 0.7623 mL 1.5246 mL 3.8116 mL
40 mM 0.1143 mL 0.5717 mL 1.1435 mL 2.8587 mL
50 mM 0.0915 mL 0.4574 mL 0.9148 mL 2.2870 mL
60 mM 0.0762 mL 0.3812 mL 0.7623 mL 1.9058 mL
80 mM 0.0572 mL 0.2859 mL 0.5717 mL 1.4294 mL
100 mM 0.0457 mL 0.2287 mL 0.4574 mL 1.1435 mL

* 備注：如您選擇水作為儲備液，請稀釋至工作液后，再用 0.22 μm 的濾膜過濾除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Eflornithine hydrochloride
目錄號：
HY-B0744A
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