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  2. Cell Cycle/DNA Damage Epigenetics Metabolic Enzyme/Protease
  3. HDAC Endogenous Metabolite
  4. Butyric acid

Butyric acid  (Synonyms: Butanoic acid)

目錄號(hào): HY-B0350 純度: 99.81%
COA 產(chǎn)品使用指南

Butyric acid 是一種 HDAC 抑制劑，具有抗腫瘤活性。

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Butyric acid Chemical Structure

Butyric acid Chemical Structure

CAS No. : 107-92-6

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Customer Review

Other Forms of Butyric acid:

    Butyric acid purchased from MCE. Usage Cited in: Neurobiol Dis. 2017 Dec 14;111:12-25.  [Abstract]

    Cdc42-Rac1 activation mediates the effect of SB on microglial process elongation. Representative images showing the activation effect of Cdc42 and Rac1 by Sodium butyrate (SB) (5 mM) at different time points (5, 10 min) in primary cultured microglia.

    • 生物活性

    • 實(shí)驗(yàn)參考方法

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Butyric acid is a histone deacetylase (HDAC) inhibitor, with anti-tumor effects in several cancers.

    IC50 & Target

    HDAC

     

    Human Endogenous Metabolite

     

    Microbial Metabolite

     

    細(xì)胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    3LLD122 IC50
    > 1000 μM
    Compound: BA
    Concentration required to inhibit the colony formation of lung carcinoma (3LLD122) cell lines by 50%
    Concentration required to inhibit the colony formation of lung carcinoma (3LLD122) cell lines by 50%
    		[PMID: 10956204]
    HEK293 EC50
    12 μM
    Compound: Butyrate
    Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
    Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
    		[PMID: 28745893]
    MIA PaCa-2 IC50
    250 μM
    Compound: BA
    Concentration required to inhibit the colony formation of pancreatic human (PACA) cell lines by 50%
    Concentration required to inhibit the colony formation of pancreatic human (PACA) cell lines by 50%
    		[PMID: 10956204]
    U-251 IC50
    932 μM
    Compound: BA
    Cytotoxicity against human U251 cells after 72 hrs by Hoechst test
    Cytotoxicity against human U251 cells after 72 hrs by Hoechst test
    		[PMID: 19007111]
    體外研究
    (In Vitro)

    Butyric acid is a HDAC inhibitor[1]. Butyric acid induces morphological changes, inhibits cell proliferation and impairs cell viability in NPC cells. Sodium Butyrate (1, 5, 10 mM) is cytotoxic to NPC cells, inducing a dose- and time-dependent decrease in cell viability, in both 5-8F and 6-10B cells. Sodium Butyrate induces nasopharyngeal carcinoma cell apoptosis by activating the mitochondrial apoptotic axis. Moreover, SOCE inhibition and disruption of the CRAC channel can attenuate the apoptosis induced by Sodium Butyrate[2]. Sodium butyrate significantly decreases cell viability, accompanied by reduced levels of p-mTOR and PCNA protein. Sodium butyrate dose-dependently induces cell cycle arrest in G0/G1 phase and reduces the numbers of cells in S phase. In addition, relative expression of p21, p27, and pro-apoptosis bak genes, and protein levels of p21Waf1/Cip1, p27Kip1, cyclinD3, CDK4, and Cleave-caspase3 are increased by higher concentrations of sodium butyrate (1, 5, 10 mM), and the levels of cyclin D1 and CDK6 are reduced by 5 and 10 mM butyrate[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    體內(nèi)研究
    (In Vivo)

    Sodium Butyrate (300 mg/kg, s.c.) provides almost complete neuroprotection in comparison with non-treated animals. Sodium butyrate results in an increased number of microglial cells to 150% of vehicle-treated animals in the ipsilateral side. Sodium butyrate promotes the polarization of microglia from M1- to M2-like phenotype after neonatal hypoxia-ischemia[3]. Sodium butyrate (300 mg/kg, s.c.) in combination with AK-7 (20 mg/kg, i.p.) significantly alleviates this reduction of the time spent exploring new objects, ameliorates the reduction of the number of Ki67-positive cells and DCX-immunoreactive neuroblasts in the dentate gyrus of the mice. In addition, sodium butyrate reverses SIRT2-related age phenotypes[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    88.11

    Formula

    C4H8O2
    CAS 號(hào)
    性狀

    液體

    顏色

    Colorless to light yellow

    中文名稱(chēng)

    丁酸
    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲(chǔ)存方式
    Pure form -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    純度 & 產(chǎn)品資料

    純度: 99.81%

    參考文獻(xiàn)
    Cell Assay
    [2]

    Cells are seeded at a density of 2,000 cells/well in 96-well plates with 200 μL culture medium containing Sodium Butyrate at different concentrations. Then, the cells are consecutively cultured for 72 h. Every 24 h, 20 μL 5 mg/mL MTT solution is added into the corresponding well, and the cells are cultured for another 4 h. Then, the solution is replaced with 150 μL DMSO, followed by gentle agitation of the plates for 15 min at room temperature. Finally, the absorbance at 492 nm is measured to represent the cell viability[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [3]

    Rats[3]
    Seven-day-old rat pups are subjected to unilateral carotid artery ligation followed by 60 min of hypoxia (7.6% O2). Sodium Butyrate (300 mg/kg) is administered in a 5-day regime with the first injection given immediately after hypoxic exposure. The damage of the ipsilateral hemisphere is evaluated by hematoxylin-eosin staining 6 days after the insult. Samples are collected at 24 and 48 h and 6 days[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    參考文獻(xiàn)

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    產(chǎn)品名稱(chēng)：
    Butyric acid
    目錄號(hào)：
    HY-B0350
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