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  2. Membrane Transporter/Ion Channel MAPK/ERK Pathway Stem Cell/Wnt NF-κB Apoptosis
  3. Sodium Channel MEK ERK NF-κB Apoptosis
  4. Lidocaine hydrochloride hydrate

Lidocaine hydrochloride hydrate  (Synonyms: 鹽酸利多卡因; Lignocaine hydrochloride hydrate)

目錄號(hào): HY-B0185B 純度: 99.90%
COA 產(chǎn)品使用指南 技術(shù)支持

Lidocaine (Lignocaine) hydrochloride hydrate 抑制涉及復(fù)雜電壓和依賴性的鈉通道 (sodium channels)。Lidocaine hydrochloride hydrate 通過(guò)調(diào)節(jié) miR-145 表達(dá)和進(jìn)一步抑制 MEK/ERK 和 NF-κB 信號(hào)通路來(lái)減少胃癌細(xì)胞的生長(zhǎng)，遷移和侵襲。Lidocaine hydrochloride hydrate 是一種酰胺衍生物，可用于研究室性心律失常。

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Lidocaine hydrochloride hydrate Chemical Structure

Lidocaine hydrochloride hydrate Chemical Structure

CAS No. : 6108-05-0

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規(guī)格 價(jià)格 是否有貨 數(shù)量
5 mg ￥100
In-stock
10 mg ￥145
In-stock
25 mg ￥232
In-stock
50 mg ￥320
In-stock
100 mg ￥449
In-stock
200 mg   詢價(jià)  
500 mg   詢價(jià)  

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Customer Review

Other Forms of Lidocaine hydrochloride hydrate:

    Lidocaine hydrochloride hydrate purchased from MCE. Usage Cited in: J Neuroinflammation. 2017 Nov 2;14(1):211.  [Abstract]

    Immunoblot results demonstrate that Lidocaine inhibits Morphine-induced upregulation of phosphorylation of p38 MAPK, but not the p38 total protein.

    查看 Sodium Channel 亞型特異性產(chǎn)品:

    查看 MEK 亞型特異性產(chǎn)品:

    查看 ERK 亞型特異性產(chǎn)品:

    查看 NF-κB 亞型特異性產(chǎn)品:

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Lidocaine (Lignocaine) hydrochloride hydrate inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride hydrate decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride hydrate is an amide derivative and has potential for the research of ventricular arrhythmia[1][2].

    IC50 & Target[1][2]

    ERK

     

    NF-κB

     

    MEK

     

    體外研究
    (In Vitro)

    Lidocaine (Lignocaine) (10 nM; 48 hours) decreases significantly cell proliferation[2].
    Lidocaine (1-10 nM; 24-72 hours) inhibits cell viability and achieves the most suppressing effects at the concentration of 10?nM and treatment time 48?hours[2].
    Lidocaine (10 nM; 48 hours) increases significantly the apoptotic cell rate[2].
    Lidocaine (10 nM; 48 hours) down-regulates Cyclin D1 and up-regulates p21 expression significantly[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Proliferation Assay[2]

    Cell Line: The human gastric cancer cell line MKN45
    Concentration: 10?nM
    Incubation Time: 48 hours
    Result: Decreased significantly cell proliferation.

    Cell Viability Assay[2]

    Cell Line: The human gastric cancer cell line MKN45
    Concentration: 1, 5 and 10?nM
    Incubation Time: 24, 48, 72 hours
    Result: Inhibited MKN45 cell viability.

    Apoptosis Analysis[2]

    Cell Line: The human gastric cancer cell line MKN45
    Concentration: 10?nM
    Incubation Time: 48 hours
    Result: Increased significantly the apoptotic cell rate.

    Western Blot Analysis[2]

    Cell Line: The human gastric cancer cell line MKN45
    Concentration: 10?nM
    Incubation Time: 48 hours
    Result: Down-regulated Cyclin D1 and up-regulated p21 expression significantly.
    體內(nèi)研究
    (In Vivo)

    Lidocaine (Lignocaine) causes completely reversible tail nerve block in rats. Mechanical nociception block produced by lidocaine has slower onset and faster recovery compared with thermal nociception block[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    288.81

    Formula

    C14H25ClN2O2
    CAS 號(hào)
    性狀

    固體

    顏色

    White to off-white

    中文名稱

    鹽酸利多卡因；鹽酸賽羅卡因；鹽酸賽洛卡因；鹽酸昔羅卡因
    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲(chǔ)存方式

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    溶解性數(shù)據(jù)
    細(xì)胞實(shí)驗(yàn)： 

    H2O 中的溶解度 : ≥ 100 mg/mL (346.25 mM)

    * "≥" means soluble, but saturation unknown.

    配制儲(chǔ)備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 3.4625 mL 17.3124 mL 34.6248 mL
    5 mM 0.6925 mL 3.4625 mL 6.9250 mL
    查看完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

    * 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

    • 摩爾計(jì)算器

    • 稀釋計(jì)算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動(dòng)物實(shí)驗(yàn)：

    以下溶解方案，請(qǐng)直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的方式助溶。

    • 方案 一

      請(qǐng)依序添加每種溶劑： Saline

      Solubility: ≥ 100 mg/mL (346.25 mM); 澄清溶液

    動(dòng)物溶解方案計(jì)算器
    請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

    給藥劑量

    mg/kg

    動(dòng)物的平均體重

    g

    每只動(dòng)物的給藥體積

    μL

    動(dòng)物數(shù)量

    只
    由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
    計(jì)算結(jié)果
    工作液所需濃度 : mg/mL
    該產(chǎn)品水溶性佳，請(qǐng)具體參考實(shí)測(cè) 水 / PBS / Saline 中的溶解度數(shù)據(jù)。
    您所需的儲(chǔ)備液濃度超過(guò)該產(chǎn)品的實(shí)測(cè)溶解度，如有需要，請(qǐng)與 MCE 中國(guó)技術(shù)支持聯(lián)系。
    純度 & 產(chǎn)品資料

    純度: 99.90%

    參考文獻(xiàn)

    完整儲(chǔ)備液配制表

    * 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 3.4625 mL 17.3124 mL 34.6248 mL 86.5621 mL
    5 mM 0.6925 mL 3.4625 mL 6.9250 mL 17.3124 mL
    10 mM 0.3462 mL 1.7312 mL 3.4625 mL 8.6562 mL
    15 mM 0.2308 mL 1.1542 mL 2.3083 mL 5.7708 mL
    20 mM 0.1731 mL 0.8656 mL 1.7312 mL 4.3281 mL
    25 mM 0.1385 mL 0.6925 mL 1.3850 mL 3.4625 mL
    30 mM 0.1154 mL 0.5771 mL 1.1542 mL 2.8854 mL
    40 mM 0.0866 mL 0.4328 mL 0.8656 mL 2.1641 mL
    50 mM 0.0692 mL 0.3462 mL 0.6925 mL 1.7312 mL
    60 mM 0.0577 mL 0.2885 mL 0.5771 mL 1.4427 mL
    80 mM 0.0433 mL 0.2164 mL 0.4328 mL 1.0820 mL
    100 mM 0.0346 mL 0.1731 mL 0.3462 mL 0.8656 mL

    * 備注：如您選擇水作為儲(chǔ)備液，請(qǐng)稀釋至工作液后，再用 0.22 μm 的濾膜過(guò)濾除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    產(chǎn)品名稱：
    Lidocaine hydrochloride hydrate
    目錄號(hào)：
    HY-B0185B
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