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  2. Apoptosis
  3. Apoptosis
  4. Sappanchalcone

Sappanchalcone 從 Caesalpinia sappan L. 中提取的黃酮類化合物，誘導(dǎo)人結(jié)腸癌細(xì)胞凋亡 (apoptosis)。

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Sappanchalcone Chemical Structure

Sappanchalcone Chemical Structure

CAS No. : 94344-54-4

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1 mg ￥3000
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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells[1].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
Macrophage IC50
32.2 μM
Compound: 7i
Inhibition of LPS stimulated TNF alpha production in Balb/c mouse peritoneal macrophages measured by ELISA plate reader method
Inhibition of LPS stimulated TNF alpha production in Balb/c mouse peritoneal macrophages measured by ELISA plate reader method
[PMID: 32361286]
體外研究
(In Vitro)

Sappanchalcone has a statistically significant effect on HCT116 cells than on SW480 cells (IC50= 37.33 μM and 54.23 μM, respectively). Sappanchalcone reduces MMP with a significant increase in ROS levels in human colon cancer cells. Sappanchalcone triggered phosphorylation of p53, which is involved in the activation of caspases and increased expression of Bax in HCT116 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

286.28

Formula

C16H14O5
CAS 號(hào)
性狀

固體

顏色

Light yellow to yellow

結(jié)構(gòu)分類
初始來源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料
參考文獻(xiàn)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Sappanchalcone
目錄號(hào)：
HY-59001
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