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  2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. Tienilic acid

Tienilic acid  (Synonyms: 替寧酸; Ticrynafen; ANP 3624)

目錄號: HY-21065 純度: 99.85%
COA 產(chǎn)品使用指南 技術(shù)支持

Tienilic acid (Ticrynafen; ANP 3624) 可作為利尿劑降血壓劑。然而，Tienilic acid 會引起肝毒性。Tienilic acid 在體外通過細(xì)胞色素 P450 (CYP) 轉(zhuǎn)化為親電子代謝物。

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Tienilic acid Chemical Structure

Tienilic acid Chemical Structure

CAS No. : 40180-04-9

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥360
In-stock
5 mg ￥328
In-stock
10 mg ￥566
In-stock
25 mg ￥1159
In-stock
50 mg ￥1738
In-stock
100 mg ￥2613
In-stock
200 mg ￥3938
In-stock
500 mg   詢價  
1 g   詢價  

* Please select Quantity before adding items.

Customer Review

Other Forms of Tienilic acid:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Tienilic acid (Ticrynafen; ANP 3624) acts as a diuretic hypotensive agent. However, Tienilic acid induces hepatotoxicity. Tienilic acid is converted into electrophilic metabolites by cytochrome P450 (CYP) in vitro[1].

體內(nèi)研究
(In Vivo)

Tienilic acid (在大鼠和小鼠中為 100 mg/lg，在豬和狗中為 5 mg/kg；PO 和靜脈注射；單劑量) 僅存在于血漿中，通過膽汁和尿液快速消除，并且在不同的物種[2]。
Tienilic acid (0-480 mg/kg；口服28 天) 降低血壓、血清、尿酸血紅蛋白，并增加 S-GPT；誘導(dǎo)小群肝細(xì)胞單細(xì)胞壞死[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats, mice, pigs and dogs[2]
Dosage: 100 mg/lg in rats and mice, 5 mg/kg in pigs and dogs
Administration: PO and IV; single dosage
Result: Only found in plasma with important bindings to the plasma proteins at the blood level; pharmacological action for several hours; eliminated by the biliary and particularly the urinary fast, practically total in the first 48 hours after administration; only small differences were observed for the parameters measured in the different species.
Animal Model: Female and male Sprague-Dawley rats[3]
Dosage: 0, 30, 120 and 480 mg/kg
Administration: PO; for 28 days
Result: Decreased blood pressure and serum uric acid at 30 mg/kg; decreased slightly hemoglobin and increased S-GPT at 120 and 480 mg/kg; significantly increase the liver weight and serum magnesium concentration in male rats, while the liver weight of female rats increased only slightly; besides, induced unicellular necrosis of small groups of liver cells.
分子量

331.18

Formula

C13H8Cl2O4S
CAS 號
性狀

固體

顏色

White to light yellow

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗： 

DMSO 中的溶解度 : 100 mg/mL (301.95 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 3.0195 mL 15.0977 mL 30.1954 mL
5 mM 0.6039 mL 3.0195 mL 6.0391 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實(shí)驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實(shí)驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻(xiàn)

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0195 mL 15.0977 mL 30.1954 mL 75.4886 mL
5 mM 0.6039 mL 3.0195 mL 6.0391 mL 15.0977 mL
10 mM 0.3020 mL 1.5098 mL 3.0195 mL 7.5489 mL
15 mM 0.2013 mL 1.0065 mL 2.0130 mL 5.0326 mL
20 mM 0.1510 mL 0.7549 mL 1.5098 mL 3.7744 mL
25 mM 0.1208 mL 0.6039 mL 1.2078 mL 3.0195 mL
30 mM 0.1007 mL 0.5033 mL 1.0065 mL 2.5163 mL
40 mM 0.0755 mL 0.3774 mL 0.7549 mL 1.8872 mL
50 mM 0.0604 mL 0.3020 mL 0.6039 mL 1.5098 mL
60 mM 0.0503 mL 0.2516 mL 0.5033 mL 1.2581 mL
80 mM 0.0377 mL 0.1887 mL 0.3774 mL 0.9436 mL
100 mM 0.0302 mL 0.1510 mL 0.3020 mL 0.7549 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Tienilic acid
目錄號：
HY-21065
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