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  1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. iGluR
  3. L-701324

L-701324 是一種口服有效的 NMDA 受體拮抗劑,通過(guò)阻斷其甘氨酸 B 結(jié)合位點(diǎn)來(lái)拮抗 NMDA 受體的活性。L-701324 與大鼠腦膜具有高親和力 (IC50=2 nM)。L-701324 具有抗抑郁活性。

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L-701324 Chemical Structure

L-701324 Chemical Structure

CAS No. : 142326-59-8

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10 mM * 1 mL in DMSO ¥343
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5 mg ¥429
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10 mg ¥701
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Customer Review

查看 iGluR 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

L-701324 is a potent, orally active NMDA receptor antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine B binding site. L-701324 binds with high affinity to rat brain membranes (IC50=2 nM). L-701324 has antidepressant activity[1][2][3].

IC50 & Target

NMDA Receptor

 

體內(nèi)研究
(In Vivo)

L-701324 (5-10 mg/kg;腹腔注射;一次) 在強(qiáng)迫游泳試驗(yàn) (FST) 和懸尾試驗(yàn) (TST) 中表現(xiàn)出抗抑郁樣潛力,而不影響小鼠的運(yùn)動(dòng)活動(dòng)[1]
L-701324 (5-10 mg/kg;腹腔注射;每日一次,持續(xù) 2 周) 在慢性不可預(yù)測(cè)的輕度應(yīng)激 (CUMS) 抑郁癥模型中產(chǎn)生強(qiáng)烈的抗抑郁樣作用,并防止 CUMS 誘發(fā)的減少海馬體中的神經(jīng)發(fā)生和 BDNF 信號(hào)級(jí)聯(lián)[1]。
L-701324 (2.5-5 mg/kg;口服一次) 通過(guò)阻斷 NMDA 受體上的 NMDA/甘氨酸敏感位點(diǎn)抑制 NMDA 受體活性,伴隨著非條件和條件沖突行為情況下的焦慮樣行為減少[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 J mice in the chronic unpredictable mild stress (CUMS) (7 weeks of age) [1]
Dosage: 5 and 10 mg/kg
Administration: Intraperitoneal injection; daily, for 2 weeks
Result: Reduced the immobility of C57BL/6 J mice.
Increased the expression of BDNF, pTrkB and pCREB in the hippocampus.
Animal Model: Male C57BL/6 J mice in the forced swim test (FST) and tail suspension test (TST) (7 weeks of age)[1]
Dosage: 5 and 10 mg/kg
Administration: Intraperitoneal injection; once
Result: Reduced the immobility of C57BL/6 J mice in the FST and TST.
Animal Model: Male Sprague-Dawley rats (280-300 g)[2]
Dosage: 2.5 and 5 mg/kg
Administration: Oral administration; once
Result: Increased in the percentage of time spent in the open arm in a dose-dependent.
Increased punished responding in the Vogel's conflict test in a dose-dependent fashion.
分子量

363.79

Formula

C21H14ClNO3

CAS 號(hào)
性狀

固體

顏色

White to off-white

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn): 

DMSO 中的溶解度 : ≥ 34 mg/mL (93.46 mM; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響,請(qǐng)使用新開封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.7488 mL 13.7442 mL 27.4884 mL
5 mM 0.5498 mL 2.7488 mL 5.4977 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液;一旦配成溶液,請(qǐng)分裝保存,避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí),請(qǐng)?jiān)?年內(nèi)使用, -20°C儲(chǔ)存時(shí),請(qǐng)?jiān)?年內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息:

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

由于實(shí)驗(yàn)過(guò)程有損耗,建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.85%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液;一旦配成溶液,請(qǐng)分裝保存,避免反復(fù)凍融造成的產(chǎn)品失效
儲(chǔ)備液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C儲(chǔ)存時(shí),請(qǐng)?jiān)?年內(nèi)使用, -20°C儲(chǔ)存時(shí),請(qǐng)?jiān)?年內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7488 mL 13.7442 mL 27.4884 mL 68.7210 mL
5 mM 0.5498 mL 2.7488 mL 5.4977 mL 13.7442 mL
10 mM 0.2749 mL 1.3744 mL 2.7488 mL 6.8721 mL
15 mM 0.1833 mL 0.9163 mL 1.8326 mL 4.5814 mL
20 mM 0.1374 mL 0.6872 mL 1.3744 mL 3.4360 mL
25 mM 0.1100 mL 0.5498 mL 1.0995 mL 2.7488 mL
30 mM 0.0916 mL 0.4581 mL 0.9163 mL 2.2907 mL
40 mM 0.0687 mL 0.3436 mL 0.6872 mL 1.7180 mL
50 mM 0.0550 mL 0.2749 mL 0.5498 mL 1.3744 mL
60 mM 0.0458 mL 0.2291 mL 0.4581 mL 1.1453 mL
80 mM 0.0344 mL 0.1718 mL 0.3436 mL 0.8590 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱:
L-701324
目錄號(hào):
HY-18698
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