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  2. GPCR/G Protein Metabolic Enzyme/Protease
  3. Oxytocin Receptor Endogenous Metabolite
  4. Oxytocin

Oxytocin  (Synonyms: 催產(chǎn)素; 縮宮素; α-Hypophamine; Oxytocic hormone)

目錄號: HY-17571 純度: 99.69%
COA 產(chǎn)品使用指南

Oxytocin (α-Hypophamine; Oxytocic hormone) 是一種多效的下丘腦肽 (hypothalamic peptide)，有助于分娩、哺乳和親社會行為。Oxytocin 可以作為一種壓力應對分子，具有抗炎、抗氧化劑和保護作用，特別是在面對逆境或創(chuàng)傷時。

MCE 的所有產(chǎn)品僅用作科學研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務

Custom Peptide Synthesis

Oxytocin Chemical Structure

Oxytocin Chemical Structure

CAS No. : 50-56-6

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥1795
In-stock
2 mg ￥650
In-stock
5 mg ￥1150
In-stock
10 mg ￥1620
In-stock
25 mg ￥2430
In-stock
50 mg ￥3400
In-stock
100 mg ￥4760
In-stock
200 mg   詢價  
500 mg   詢價  

* Please select Quantity before adding items.

Customer Review

Other Forms of Oxytocin:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma[1][2].

IC50 & Target

Human Endogenous Metabolite

 

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO EC50
0.04 nM
Compound: 1; OT
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
Agonist activity at human oxytocin receptor expressed in CHO cells assessed as increase in intracellular calcium flux measured for 90 sec by fluo-4 dye based FLIPR assay
[PMID: 27297999]
CHO EC50
10.8 nM
Compound: OT
Agonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay
Agonist activity at human oxytocin receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay
[PMID: 21428295]
CHO EC50
24.5 nM
Compound: OT
Agonist activity at human vasopressin V1b receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay
Agonist activity at human vasopressin V1b receptor expressed CHO cells assessed as induction of phospholipase C activity after 15 mins by inositol phosphate accumulation assay
[PMID: 21428295]
CHO-K1 EC50
2.3 nM
Compound: 1, OT
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
Agonist activity at human oxytocin receptor expressed in CHO-K1 cells after 5 hrs by firefly luciferase reporter gene assay
[PMID: 24874785]
COS-1 EC50
15 nM
Compound: 1, OT
Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay
Activity at oxytocin receptor expressed in COS1 cells assessed as IP-one generation by HTRF assay
[PMID: 21117646]
HEK293 IC50
> 10000 nM
Compound: 1, OT
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
Antagonist activity at human vasopressin V1a expressed in AVP-stimulated HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
[PMID: 24874785]
HEK293 EC50
0.0046 nM
Compound: OT
Agonist activity at human OTR receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
Agonist activity at human OTR receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
[PMID: 31229420]
HEK293 EC50
0.01 nM
Compound: OT
Agonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
Agonist activity at recombinant human OTR expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
[PMID: 30896946]
HEK293 EC50
0.18 nM
Compound: OT
Agonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
Agonist activity at human V1A receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
[PMID: 31229420]
HEK293 EC50
0.19 nM
Compound: OT
Agonist activity at recombinant human V1a receptor expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
Agonist activity at recombinant human V1a receptor expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
[PMID: 30896946]
HEK293 EC50
0.2 nM
Compound: OT
Agonist activity at human V1B receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
Agonist activity at human V1B receptor expressed in HEK293 cells assessed as intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
[PMID: 31229420]
HEK293 EC50
0.24 nM
Compound: OT
Agonist activity at recombinant human V1b receptor expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
Agonist activity at recombinant human V1b receptor expressed in HEK293 cells assessed as increase in intracellular calcium level measured at 3 secs interval for 5 mins by fura-2/AM dye based micro spectrofluorometric method
[PMID: 30896946]
HEK293 EC50
10 nM
Compound: 1, OT
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
Agonist activity at human vasopressin V1a expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
[PMID: 24874785]
HEK293 EC50
2.1 nM
Compound: 1; OT
Agonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
Agonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay
[PMID: 27420737]
HEK293 EC50
240 nM
Compound: 1, OT
Agonist activity at human vasopressin V1b expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
Agonist activity at human vasopressin V1b expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
[PMID: 24874785]
HEK293 EC50
5 nM
Compound: OT
Agonist activity at wild type OTR (unknown origin) expressed in HEK293 cells assessed as intracellular calcium flux after 3 mins by fluorescence assay
Agonist activity at wild type OTR (unknown origin) expressed in HEK293 cells assessed as intracellular calcium flux after 3 mins by fluorescence assay
[PMID: 25642985]
HEK293 EC50
7.3 nM
Compound: 1, OT
Agonist activity at human vasopressin V2 expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
Agonist activity at human vasopressin V2 expressed in HEK293 cells after 5 hrs by firefly luciferase reporter gene assay
[PMID: 24874785]
HEK293 EC50
8 nM
Compound: OT
Agonist activity at SNAP-tagged oxytocin receptor (unknown origin) expressed in HEK293 cells assessed as intracellular calcium flux after 3 mins by fluorescence assay
Agonist activity at SNAP-tagged oxytocin receptor (unknown origin) expressed in HEK293 cells assessed as intracellular calcium flux after 3 mins by fluorescence assay
[PMID: 25642985]
體內(nèi)研究
(In Vivo)

在 LMA 任務期間，大鼠核心體溫略有下降。Oxytocin (皮下注射；0.1 mg/kg - 0.3 mg/kg；單劑量) 產(chǎn)生的低溫效應 (0.3 mg/kg) 顯著高于生理鹽水或兩種較低劑量的 Oxytocin 。0.3 mg/kg 的 Oxytocin 在注射后 15-60 分鐘內(nèi)產(chǎn)生的溫度下降幅度顯著高于載體，而 0.1 mg/kg 的 Oxytocin 僅在 30 分鐘時間點略微降低溫度[1]。與鹽水對照組相比，Oxytocin (0.1 mg/kg)參與了顯著更多的身體嗅探和肛門生殖器嗅探[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fifty-six male Lister-hooded rats (150-200?g)[1]
Dosage: 0.1?mg/kg-0.3 mg/kg
Administration: Subcutaneous?injection; 0.1?mg/kg-0.3 mg/kg; single dose
Result: Produced significantly greater hypothermia (at 0.3 mg/kg) than the saline group.
分子量

1007.19

Formula

C43H66N12O12S2
CAS 號
性狀

固體

顏色

White to off-white

Sequence

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (Disulfide bridge:Cys1-Cys6)
Sequence Shortening

CYIQNCPLG-NH2 (Disulfide bridge:Cys1-Cys6)
中文名稱

催產(chǎn)素；縮宮素
結(jié)構(gòu)分類
初始來源

the paraventricular and supraoptic nuclei of the hypothalamus
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 100 mg/mL (99.29 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 0.9929 mL 4.9643 mL 9.9286 mL
5 mM 0.1986 mL 0.9929 mL 1.9857 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: 99.79%

參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9929 mL 4.9643 mL 9.9286 mL 24.8215 mL
5 mM 0.1986 mL 0.9929 mL 1.9857 mL 4.9643 mL
10 mM 0.0993 mL 0.4964 mL 0.9929 mL 2.4822 mL
15 mM 0.0662 mL 0.3310 mL 0.6619 mL 1.6548 mL
20 mM 0.0496 mL 0.2482 mL 0.4964 mL 1.2411 mL
25 mM 0.0397 mL 0.1986 mL 0.3971 mL 0.9929 mL
30 mM 0.0331 mL 0.1655 mL 0.3310 mL 0.8274 mL
40 mM 0.0248 mL 0.1241 mL 0.2482 mL 0.6205 mL
50 mM 0.0199 mL 0.0993 mL 0.1986 mL 0.4964 mL
60 mM 0.0165 mL 0.0827 mL 0.1655 mL 0.4137 mL
80 mM 0.0124 mL 0.0621 mL 0.1241 mL 0.3103 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Oxytocin
目錄號：
HY-17571
需求量：