Itraconazole-d₃ (Synonyms: 伊曲康唑 -d₃; R51211-d₃)

目錄號: HY-17514S1 純度: 99.62%: FAQs
Data Sheet SDS COA 產(chǎn)品使用指南

摩爾計算器

Itraconazole-d₃ 是 Itraconazole (HY-17514) 的氘代物。

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Itraconazole-d<sub>3</sub> Chemical Structure

Itraconazole-d₃ Chemical Structure

CAS No. : 1217512-35-0

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1 mg	￥3900	In-stock
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生物活性
純度 & 產(chǎn)品資料
參考文獻

生物活性

Itraconazole-d₃ is the deuterium labeled Itraconazole (HY-17514)[1].

細胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 30 μM Compound: ITC	Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 34388384]
A549	IC₅₀	> 50 μM Compound: 2; ILC	Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay	[PMID: 34749201]
A549	IC₅₀	182 μg/mL Compound: IT	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 24513049]
A549	IC₅₀	3 μM Compound: Itraconazole	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 36184028]
C3H 10T1/2	IC₅₀	0.063 μM Compound: 1; ITZ	Inhibition of hedgehog pathway in mouse C3H10T1/2 cells assessed as downregulation of Gli1 mRNA expression after 24 hrs by qPCR method Inhibition of hedgehog pathway in mouse C3H10T1/2 cells assessed as downregulation of Gli1 mRNA expression after 24 hrs by qPCR method	[PMID: 27014922]
CHO	IC₅₀	> 40 μM Compound: 2	Inhibition of human ERG expressed in CHO cells by whole-cell patch clamp assay Inhibition of human ERG expressed in CHO cells by whole-cell patch clamp assay	[PMID: 24564525]
HEK293	IC₅₀	> 250 μM Compound: Itraconazole	Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay	[PMID: 29626797]
HEK-293T	IC₅₀	> 50 μM Compound: 2; ILC	Cytotoxicity against human HEK293T cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay Cytotoxicity against human HEK293T cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay	[PMID: 34749201]
Hepatocyte	IC₅₀	0.07 μM Compound: Itraconazole	Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS method Inhibition of CYP3A4 in human hepatocytes using testosterone as substrate by HPLC/MS/MS method	[PMID: 24948565]
HepG2	IC₅₀	> 50 μM Compound: 2; ILC	Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay	[PMID: 34749201]
HepG2	IC₅₀	142 μg/mL Compound: IT	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 24513049]
HepG2	IC₅₀	7.87 μM Compound: Itraconazole	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 36184028]
HT-1080	IC₅₀	201.63 μg/mL Compound: IT	Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay	[PMID: 24513049]
HUVEC	IC₅₀	0.17 μM Compound: 1	Anti-angiogenic activity against HUVEC after 24 hrs by scintillation counting based [3H]-thymidine incorporation assay Anti-angiogenic activity against HUVEC after 24 hrs by scintillation counting based [3H]-thymidine incorporation assay	[PMID: 30481027]
HUVEC	GI₅₀	0.4 μM Compound: 1; ITZ	Antiproliferative activity against HUVEC assessed as inhibition of VEGF induced cell proliferation after 72 hrs by MTS assay Antiproliferative activity against HUVEC assessed as inhibition of VEGF induced cell proliferation after 72 hrs by MTS assay	[PMID: 27014922]
HUVEC	IC₅₀	160 nM Compound: 1; ITZ	Antiproliferative activity against HUVEC assessed as inhibition of VEGF induced cell proliferation using methyl-[3H]thymidine after 36 hrs Antiproliferative activity against HUVEC assessed as inhibition of VEGF induced cell proliferation using methyl-[3H]thymidine after 36 hrs	[PMID: 27014922]
HUVEC	IC₅₀	170 nM Compound: 1	Inhibition of NPC1/VDAC1 in HUVEC cells assessed as reduction in cell proliferation pretreated for 24 hrs followed by [3H]thymidine incorporation by scintillation counter method Inhibition of NPC1/VDAC1 in HUVEC cells assessed as reduction in cell proliferation pretreated for 24 hrs followed by [3H]thymidine incorporation by scintillation counter method	[PMID: 32550989]
L02	IC₅₀	> 50 μM Compound: Itraconazole	Cytotoxicity against human L02 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Cytotoxicity against human L02 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 36184028]
LLC-PK1	IC₅₀	0.2 μM Compound: Itraconazole	Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	[PMID: 12699389]
LLC-PK1	IC₅₀	0.7 μM Compound: Itraconazole	Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	[PMID: 12699389]
LLC-PK1	IC₅₀	2.1 μM Compound: Itraconazole	Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	[PMID: 12699389]
MCF-10A	IC₅₀	> 300 μM Compound: IT	Cytotoxicity against human MCF10A cells after 48 hrs by WST1 assay Cytotoxicity against human MCF10A cells after 48 hrs by WST1 assay	[PMID: 24513049]
MCF7	IC₅₀	> 30 μM Compound: ITC	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 34388384]
MCF7	IC₅₀	> 50 μM Compound: 2; ILC	Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay	[PMID: 34749201]
Medulloblastoma cell	GI₅₀	0.44 μM Compound: 1; ITZ	Antiproliferative activity against mouse MERP MB cells assessed as cell growth inhibition using methyl-[3H]thymidine after 48 hrs by liquid scintillation spectrophotometry Antiproliferative activity against mouse MERP MB cells assessed as cell growth inhibition using methyl-[3H]thymidine after 48 hrs by liquid scintillation spectrophotometry	[PMID: 27014922]
PBMC	IC₅₀	1.53 μM Compound: Itraconazole	Cytotoxicity against human PBMC assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against human PBMC assessed as cell viability after 72 hrs by MTT assay	[PMID: 24485783]
THLE-2	IC₅₀	> 30 μM Compound: ITC	Cytotoxicity against human THLE-2 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay Cytotoxicity against human THLE-2 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay	[PMID: 34388384]
Vero	IC₅₀	> 50 μg/mL Compound: ITZ	Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay	[PMID: 23831506]

分子量

708.65

Formula

C₃₅H₃₅D₃Cl₂N₈O₄

CAS 號

1217512-35-0

非標(biāo)記 CAS

84625-61-6

性狀

固體

顏色

White to off-white

中文名稱

伊曲康唑-d₃；依他康唑-d₃

運輸條件

Room temperature in continental US; may vary elsewhere.

儲存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性數(shù)據(jù)

細胞實驗：

DMSO 中的溶解度 : ≥ 0.5 mg/mL (0.71 mM; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

DMF 中的溶解度 : ≥ 0.5 mg/mL (0.71 mM)

* "≥" means soluble, but saturation unknown.

摩爾計算器
稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

濃度 _(start)

體積 _(start)

濃度 _(final)

體積 _(final)

動物溶解方案計算器

請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

每只動物的給藥體積

μL

動物數(shù)量

只

由于實驗過程有損耗，建議您多配一只動物的量

計算結(jié)果

工作液所需濃度 : mg/mL

純度 & 產(chǎn)品資料

純度: 99.62%

選擇批次：

Data Sheet (584 KB) SDS (252 KB)

COA (291 KB) LCMS (94 KB)

產(chǎn)品使用指南 (1538 KB)

參考文獻

[1]. Dwivedi A, et al. Ultra-performance liquid chromatography electrospray ionization-tandem mass spectrometry method for the simultaneous determination of itraconazole and hydroxy itraconazole in human plasma. J Pharm Anal. 2014 Oct;4(5):316-324. [Content Brief]

Itraconazole-d₃ 相關(guān)分類

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Itraconazole-d₃1217512-35-0R51211-d₃伊曲康唑-d₃依他康唑-d₃AntibioticFungalAutophagyHedgehogBacterialCytochrome P450CYPsInhibitorinhibitorinhibit

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Itraconazole-d₃ (Synonyms: 伊曲康唑 -d₃; R51211-d₃)

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Itraconazole-d3 (Synonyms: 伊曲康唑 -d3; R51211-d3)

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Itraconazole-d₃ (Synonyms: 伊曲康唑 -d₃; R51211-d₃)

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Itraconazole-d₃ 相關(guān)抗體

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Itraconazole-d₃ 相關(guān)分類