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  2. Anti-infection
  3. Antibiotic Bacterial
  4. Sancycline hydrochloride

Sancycline hydrochloride  (Synonyms: Bonomycin hydrochloride; 6-Demethyl-6-deoxytetracycline hydrochloride)

目錄號: HY-17466A
產(chǎn)品使用指南 技術(shù)支持

Sancycline (6-Demethyl-6-deoxytetracycline) hydrochloride 與 30 S 核糖體亞基 (30 S ribosomal subunit) 可逆結(jié)合，并通過阻斷氨基?；?tRNA 進入核糖體 A 位點來抑制蛋白質(zhì)翻譯，與四環(huán)素 (HY-A0107) 類似。Sancycline hydrochloride, 由四個線性融合的 6 元環(huán)和 4 個立體中心組成，是由 Declomycin 的氯和芐羥基基團經(jīng)過氫熱解制得的一種半合成四環(huán)素 (HY-A0107)。

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Sancycline hydrochloride Chemical Structure

Sancycline hydrochloride Chemical Structure

CAS No. : 6625-20-3

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規(guī)格 價格 是否有貨
5 mg ￥2550
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Sancycline hydrochloride 的其他形式現(xiàn)貨產(chǎn)品:

Customer Review

Other Forms of Sancycline hydrochloride:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Sancycline (6-Demethyl-6-deoxytetracycline) hydrochloride acts by reversibly binding to the 30 S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome a site similar to tetracycline (HY-A0107). Sancycline hydrochloride, four linearly fused six-membered rings with four stereocenters, is a rare semi-synthetic tetracycline (HY-A0107) prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of Declomycin[1][2][3].

IC50 & Target

Tetracycline

 

體外研究
(In Vitro)

Sancycline hydrochloride (400 μM, 24 小時) 降低 2 氯乙基硫醚 (CEES) 和氮芥 (NM) 誘導(dǎo)的角膜損傷，并在一定程度上抑制基質(zhì)金屬蛋白酶 (MMP)-9 在基底膜區(qū) (BMZ) 的表達[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence[2]

Cell Line: Frozen corneal sections
Concentration: 400 μM
Incubation Time: 24 h
Result: lnhibited MMP-9 expression to some degree in the NM-exposed corneas.
分子量

450.87

Formula

C21H23ClN2O7
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

山環(huán)素鹽酸鹽
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻

Sancycline hydrochloride 相關(guān)分類

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Sancycline hydrochloride
目錄號：
HY-17466A
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