Emtricitabine-¹³C,¹⁵N₂ (BW1592-¹³C,¹⁵N₂) is a ¹³C- and ¹⁵N-labeled Emtricitabine (HY-17427). Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with an EC₅₀ of 0.01 μM in PBMC cell. It is an antiviral agent for the treatment of HIV infection.

氫、碳和其他元素的穩(wěn)定重同位素已被納入藥物分子中，主要作為藥物開(kāi)發(fā)過(guò)程中定量的示蹤劑。氘化引起了人們的關(guān)注，因?yàn)樗赡苡绊懰幬锏乃幋鷦?dòng)力學(xué)和代謝譜^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

250.23

C₇¹³CH₁₀FN¹⁵N₂O₃S

1217820-69-3

143491-57-0

恩曲他濱-¹³C,¹⁵N₂

Room temperature in continental US; may vary elsewhere.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246.  [Content Brief]

  [2]. Xu P, et al. Combined Medication of Antiretroviral Drugs Tenofovir Disoproxil Fumarate, Emtricitabine, and Raltegravir Reduces Neural Progenitor Cell Proliferation In Vivo and In Vitro. J Neuroimmune Pharmacol. 2017 Dec;12(4):682-692.  [Content Brief]

  [3]. Faltz M, et al. Effect of the Anti-retroviral Drugs Efavirenz, Tenofovir and Emtricitabine on Endothelial Cell Function: Role of PARP. Cardiovasc Toxicol. 2017 Jan 3. [Epub ahead of print]  [Content Brief]

  [4]. Szczech GM, Wang LH, Walsh JP, Reproductive toxicology profile of emtricitabine in mice and rabbits. Reprod Toxicol. 2003 Jan-Feb;17(1):95-108.  [Content Brief]

  [5]. Saag MS, et al. Emtricitabine, a new antiretroviral agent with activity against HIV and hepatitis B virus. Clin Infect Dis. 2006 Jan 1;42(1):126-31.  [Content Brief]