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  2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Naloxone

Naloxone  (Synonyms: 納洛酮)

目錄號: HY-17417A 純度: 99.71%
COA 產品使用指南 技術支持

Naloxone 是 Opioid receptor 的拮抗劑。Naloxone 可減輕阿片類藥物過量引起的呼吸抑制。Naloxone 可能會引起肺水腫和心律失常。

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Naloxone Chemical Structure

Naloxone Chemical Structure

CAS No. : 465-65-6

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規(guī)格 價格 是否有貨 數量
5 mg ￥520
In-stock
10 mg ￥780
In-stock
25 mg ￥1404
In-stock
50 mg ￥2120
In-stock
100 mg ￥3180
In-stock
200 mg ￥4770
In-stock
500 mg   詢價  
1 g   詢價  

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Customer Review

Other Forms of Naloxone:

Proliferation Assay

    Naloxone purchased from MCE. Usage Cited in: Eur J Pain. 2017 May;21(5):804-814.  [Abstract]

    The SCS1 (early SCS)-mediated increase in the ipsilateral:contralateral PWT ratio (compared to pre-SCS) is significantly reduced by the opioid receptor antagonist, Naloxone, which is administered 10 min before SCS1.

    • 生物活性

    • 純度 & 產品資料

    • 參考文獻

    生物活性

    Naloxone is an antagonist of Opioid receptor. Naloxone alleviates opioid-overdose-induced respiratory depression. Naloxone may cause pulmonary edema and cardiac arrhythmias[1].

    細胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    CHO IC50
    146 nM
    Compound: Naloxone
    Antagonist activity at human delta opioid receptor expressed in CHO cell membranes assessed as reduction in SNC80-induced [35S]GTPgammaS binding incubated for 1 hr
    Antagonist activity at human delta opioid receptor expressed in CHO cell membranes assessed as reduction in SNC80-induced [35S]GTPgammaS binding incubated for 1 hr
    		[PMID: 30996778]
    CHO IC50
    15.37 nM
    Compound: 3; NLX
    Antagonist activity at mouse mu opioid receptor expressed in CHO cells cotransfected with Galphaqi5 assessed as inhibition of DAMGO-induced increase in intracellular calcium concentration preincubated for 60 mins in Fluo4AM solution followed by compound a
    Antagonist activity at mouse mu opioid receptor expressed in CHO cells cotransfected with Galphaqi5 assessed as inhibition of DAMGO-induced increase in intracellular calcium concentration preincubated for 60 mins in Fluo4AM solution followed by compound a
    		[PMID: 31782922]
    CHO IC50
    153 nM
    Compound: Naloxone
    Antagonist activity at human delta opioid receptor expressed in CHO cell membranes assessed as reduction in SNC80-induced [35S]GTPgammaS binding preincubated for 5 mins followed by SNC80 addition and measured after 1 hr
    Antagonist activity at human delta opioid receptor expressed in CHO cell membranes assessed as reduction in SNC80-induced [35S]GTPgammaS binding preincubated for 5 mins followed by SNC80 addition and measured after 1 hr
    		[PMID: 32530286]
    CHO IC50
    78.2 nM
    Compound: Naloxone
    Antagonist activity at human DOR expressed in CHO cell membranes assessed as reduction in SNC80-induced response incubated for 1 hr by [35S]-GTPgammaS coupling assay
    Antagonist activity at human DOR expressed in CHO cell membranes assessed as reduction in SNC80-induced response incubated for 1 hr by [35S]-GTPgammaS coupling assay
    		[PMID: 31834798]
    HEK-293T IC50
    0.045 μM
    Compound: Naloxone
    Antagonist activity at recombinant human MOR expressed in HEK293T cells assessed as reduction in DAMGO-induced inhibition of forskolin-stimulated cAMP level preincubated for 15 to 20 mins followed by DAMGO and forskolin addition by GloSensor assay
    Antagonist activity at recombinant human MOR expressed in HEK293T cells assessed as reduction in DAMGO-induced inhibition of forskolin-stimulated cAMP level preincubated for 15 to 20 mins followed by DAMGO and forskolin addition by GloSensor assay
    		[PMID: 28726402]
    體內研究
    (In Vivo)

    Naloxone (2.0 mg/kg with constant infusion of 1.7 mg/kg/h) causes a significant improvement in neurobehavioral outcome which persists up to 4 weeks postinjury in rat. Naloxone treatment causes a modest and nonsignificant increase in mean arterial blood pressure (MAP)[1]. Naloxone (0.4 mg/kg) causes memory facilitation and antagonizes the amnestic effect of ACTH and epinephrine in rat[2]. Naloxone treatment diminishes the strength of the initial tetanus in a dose-related manner in cats. Naloxone (5 or 10 mg/kg, i.v.) causes subsequent doses of morphine to produce less PTP depression but has no effect on maximal twitch depression[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    327.37

    Formula

    C19H21NO4
    CAS 號
    性狀

    固體

    顏色

    White to off-white

    中文名稱

    納洛酮
    運輸條件

    Room temperature in continental US; may vary elsewhere.
    儲存方式

    4°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

    純度 & 產品資料
    參考文獻

    • 摩爾計算器

    • 稀釋計算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   體積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    產品名稱：
    Naloxone
    目錄號：
    HY-17417A
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