6 | 1092540-50-5 | BMS-232632-d6 | 阿扎那韋-d6 | Isotope-Labeled Compounds | HIV | HIV Protease | SARS-CoV | Cytochrome P450 | P-glycoprotein | Endogenous Metabolite | Human immunodeficiency virus | SARS coronavirus | CYPs | P-gp | Pgp | Multidrug resistance protein 1 | MDR1 | ATP-binding cassette sub-family B member 1 | ABCB1 | Cluster of differentiation 243 | CD243 | Inhibitor | inhibitor | inhibit"/>

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  2. Others Anti-infection Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  3. Isotope-Labeled Compounds HIV HIV Protease SARS-CoV Cytochrome P450 P-glycoprotein Endogenous Metabolite
  4. Atazanavir-d6

Atazanavir-d6  (Synonyms: 阿扎那韋-d6; BMS-232632-d6)

目錄號: HY-17367S4 純度: 99.28%
COA 產(chǎn)品使用指南 技術(shù)支持

Atazanavir-d6 是 Atazanavir 氘代物。Atazanavir (BMS-232632) 是一種高選擇性的 HIV-1蛋白酶抑制劑，用于艾滋病毒感染的研究。Atazanavir 是 CYP3A4 的底物和抑制劑，也是 P-糖蛋白的抑制劑和誘導(dǎo)劑。Atazanavir 也是 SARS-CoV 3CLpro 的抑制劑，IC50 為 3.49 μM。

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Atazanavir-d<sub>6</sub> Chemical Structure

Atazanavir-d6 Chemical Structure

CAS No. : 1092540-50-5

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規(guī)格 價格 是否有貨 數(shù)量
500 μg ￥2020
In-stock
1 mg ￥3250
In-stock
5 mg   詢價  
10 mg   詢價  

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Other Forms of Atazanavir-d6:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Atazanavir-d6 is deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration[1]. Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp)[2]. Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM[3].

體外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

710.89

Formula

C38H46D6N6O7
CAS 號
非標(biāo)記 CAS
性狀

固體

顏色

White to off-white

中文名稱

阿扎那韋-d6
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料

純度: 99.28%

參考文獻(xiàn)

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The molarity calculator equation

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質(zhì)量   濃度   體積   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Atazanavir-d6
目錄號：
HY-17367S4
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