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  2. MAPK/ERK Pathway
  3. Ribosomal S6 Kinase (RSK)
  4. SL 0101-1

SL 0101-1 (SL0101) 是從熱帶植物F. refracta 中提取得到的山萘酚糖苷，是能穿透細(xì)胞的、選擇性的、可逆的、ATP競(jìng)爭(zhēng)性的 p90核糖體S6激酶(RSK) 的抑制劑，其IC50 值為 89 nM。SL 0101-1 (SL0101) 是選擇性的 RSK1/2 抑制劑，其 Ki 值為 1 μM。

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SL 0101-1 Chemical Structure

SL 0101-1 Chemical Structure

CAS No. : 77307-50-7

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥6704
In-stock
1 mg ￥1900
In-stock
5 mg ￥5900
In-stock
10 mg   詢價(jià)  
50 mg   詢價(jià)  

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查看 Ribosomal S6 Kinase (RSK) 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM[1]. SL 0101-1 (SL0101) is a selective RSK1/2 inhibitor, with a Ki of 1 μM[2].

IC50 & Target

RSK1

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCC70 IC50
15 μM
Compound: 52; SL0101
Anticancer activity against human HCC70 cells assessed as cell growth inhibition incubated up to 72 hrs by Cell-Titre Glo assay
Anticancer activity against human HCC70 cells assessed as cell growth inhibition incubated up to 72 hrs by Cell-Titre Glo assay
[PMID: 33650861]
MCF7 IC50
45.6 μM
Compound: 1, SL0101
Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter-GloTM assay
Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter-GloTM assay
[PMID: 22464132]
MDA-MB-231 IC50
3 μM
Compound: 52; SL0101
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated up to 72 hrs by Cell-Titre Glo assay
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated up to 72 hrs by Cell-Titre Glo assay
[PMID: 33650861]
Sf9 IC50
0.583 μM
Compound: 1, SL0101
Inhibition of His-tagged RSK2 expressed in Sf9 cells using ERalpha-Ser167 RLASTND as substrate after 120 mins by chemiluminescence assay
Inhibition of His-tagged RSK2 expressed in Sf9 cells using ERalpha-Ser167 RLASTND as substrate after 120 mins by chemiluminescence assay
[PMID: 22464132]
Sf9 IC50
0.99 μM
Compound: 1, SL0101
Inhibition of recombinant RSK2 (unknown origin) expressed in baculovirus infected Sf9 cells assessed as decrease in substrate phosphorylation using GST-fusion protein containing ERalpha-Ser167 sequence-RLASTND as substrate by chemiluminescence analysis
Inhibition of recombinant RSK2 (unknown origin) expressed in baculovirus infected Sf9 cells assessed as decrease in substrate phosphorylation using GST-fusion protein containing ERalpha-Ser167 sequence-RLASTND as substrate by chemiluminescence analysis
[PMID: 23519677]
Sf9 IC50
89 nM
Compound: SL0101
Inhibition of his-tagged active RSK2 (unknown origin) expressed in Sf9 cells after 10 to 45 mins by ELISA
Inhibition of his-tagged active RSK2 (unknown origin) expressed in Sf9 cells after 10 to 45 mins by ELISA
[PMID: 25147152]
體外研究
(In Vitro)

SL 0101-1 (SL0101) 在人乳腺癌細(xì)胞系 MCF-7 中表現(xiàn)出增殖抑制作用，并在 G1 期[1] 產(chǎn)生細(xì)胞周期阻滯。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

516.45

Formula

C25H24O12
CAS 號(hào)
性狀

固體

顏色

White to yellow

結(jié)構(gòu)分類
初始來(lái)源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 10 mg/mL (19.36 mM; 超聲加熱助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開(kāi)封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 1.9363 mL 9.6815 mL 19.3630 mL
5 mM 0.3873 mL 1.9363 mL 3.8726 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: ≥98.0%

參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9363 mL 9.6815 mL 19.3630 mL 48.4074 mL
5 mM 0.3873 mL 1.9363 mL 3.8726 mL 9.6815 mL
10 mM 0.1936 mL 0.9681 mL 1.9363 mL 4.8407 mL
15 mM 0.1291 mL 0.6454 mL 1.2909 mL 3.2272 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
SL 0101-1
目錄號(hào)：
HY-15237
需求量：