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  2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Anti-infection
  3. HSP Bacterial Influenza Virus Antibiotic
  4. Geldanamycin

Geldanamycin  (Synonyms: 格爾德霉素)

目錄號: HY-15230 純度: 99.78%
COA 產(chǎn)品使用指南

Geldanamycin是 Hsp90 抑制劑，具有抗許多革蘭氏陽性和一些革蘭氏陰性細(xì)菌的活性。Geldanamycin 還具有抗流感病毒 H5N1 的活性。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù)

Geldanamycin Chemical Structure

Geldanamycin Chemical Structure

CAS No. : 30562-34-6

1.  客戶無需承擔(dān)相應(yīng)的運輸費用。

2.  同一機構(gòu)（單位）同一產(chǎn)品試用裝僅限申領(lǐng)一次，同一機構(gòu)（單位）一年內(nèi)

     可免費申領(lǐng)三個不同產(chǎn)品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥1544
In-stock
1 mg ￥500
In-stock
5 mg ￥1234
In-stock
10 mg ￥1989
In-stock
25 mg ￥3282
In-stock
50 mg ￥4595
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100 mg 現(xiàn)貨 詢價
200 mg   詢價  
500 mg   詢價  

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Customer Review

Other Forms of Geldanamycin:

    Geldanamycin purchased from MCE. Usage Cited in: J Cell Biochem. 2019 Sep;120(9):16254-16263.  [Abstract]

    Caspase 3, caspase 9, cleaved caspase 3, cleaved caspase 9, and β-actin protein expression analyzed by Western blot with the treatment of Geldanamycin.

    Geldanamycin purchased from MCE. Usage Cited in: J Cell Biochem. 2019 Sep;120(9):16254-16263.  [Abstract]

    Bcl2, Bax, and β-actin protein expression is analyzed by Western blot with the treatment of Geldanamycin.

    Geldanamycin purchased from MCE. Usage Cited in: J Cell Biochem. 2018 Oct 10.  [Abstract]

    Geldanamycin (GA) attenuatea TNF-α-mediated activation of MAPK and NF-κB signaling pathways.

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus H5N1 activities.

    IC50 & Target[4]

    HSP90

    1.2 μM (Kd)

    細(xì)胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    A2780 IC50
    0.07 μM
    Compound: 1
    Antiproliferative activity against human A2780 assessed as reduction in cell viability measured after 96 hrs by MTT assay
    Antiproliferative activity against human A2780 assessed as reduction in cell viability measured after 96 hrs by MTT assay
    		[PMID: 27476419]
    A-375 IC50
    0.06 μM
    Compound: 1
    Antiproliferative activity against human A375 assessed as reduction in cell viability measured after 96 hrs by MTT assay
    Antiproliferative activity against human A375 assessed as reduction in cell viability measured after 96 hrs by MTT assay
    		[PMID: 27476419]
    A-431 IC50
    0.2 μM
    Compound: geldanamycin
    Antiproliferative activity against human A431 cells after 72 hrs
    Antiproliferative activity against human A431 cells after 72 hrs
    		[PMID: 20655237]
    A-431 IC50
    40 nM
    Compound: 1, GA
    Cytotoxicity against human A431 cells after 72 hrs by MTT assay
    Cytotoxicity against human A431 cells after 72 hrs by MTT assay
    		[PMID: 25277067]
    A549 IC50
    0.1 μM
    Compound: GA
    Antiproliferative activity against human A549 cells after 72 hrs by SRB assay
    Antiproliferative activity against human A549 cells after 72 hrs by SRB assay
    		[PMID: 29172085]
    A549 IC50
    0.109 μM
    Compound: Geldanamycin
    Anticancer activity against human A549 cells measured after 72 hrs by SRB assay
    Anticancer activity against human A549 cells measured after 72 hrs by SRB assay
    		[PMID: 27283788]
    A549 IC50
    0.15 μM
    Compound: geldanamycin
    Cytotoxicity against human A549 cells after 2 days by AlamarBlue assay
    Cytotoxicity against human A549 cells after 2 days by AlamarBlue assay
    		[PMID: 23947794]
    A549 IC50
    0.99 μM
    Compound: GDM
    Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay
    Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay
    		[PMID: 32663707]
    A549 IC50
    97 nM
    Compound: 1, GA
    Cytotoxicity against human A549 cells after 72 hrs by MTT assay
    Cytotoxicity against human A549 cells after 72 hrs by MTT assay
    		[PMID: 25277067]
    BGC-823 IC50
    0.11 μM
    Compound: 1
    Antiproliferative activity against human BGC823 assessed as reduction in cell viability measured after 96 hrs by MTT assay
    Antiproliferative activity against human BGC823 assessed as reduction in cell viability measured after 96 hrs by MTT assay
    		[PMID: 27476419]
    BGC-823 IC50
    40 nM
    Compound: 1, GA
    Cytotoxicity against human BGC823 cells after 72 hrs by MTT assay
    Cytotoxicity against human BGC823 cells after 72 hrs by MTT assay
    		[PMID: 25277067]
    CAKI-1 IC50
    0.056 μM
    Compound: Geldanamycin
    Anticancer activity against human Caki1 cells measured after 72 hrs by SRB assay
    Anticancer activity against human Caki1 cells measured after 72 hrs by SRB assay
    		[PMID: 27283788]
    CNE2Z IC50
    0.31 μM
    Compound: GM
    Antiproliferative activity against human CNE2Z cells assessed as cell growth inhibition by MTT assay
    Antiproliferative activity against human CNE2Z cells assessed as cell growth inhibition by MTT assay
    		[PMID: 32527461]
    HCT-116 EC50
    0.03 μM
    Compound: 1
    Antiproliferative activity against human HCT116 cells measured on day 4 by Cell titer-glo assay
    Antiproliferative activity against human HCT116 cells measured on day 4 by Cell titer-glo assay
    		[PMID: 21420297]
    HCT-116 EC50
    0.03 μM
    Compound: 1
    Antiproliferative activity against human HCT116 cells by luminescence assay
    Antiproliferative activity against human HCT116 cells by luminescence assay
    		[PMID: 21605975]
    HCT-116 IC50
    0.1 μM
    Compound: 1
    Antiproliferative activity against human HCT116 assessed as reduction in cell viability measured after 96 hrs by MTT assay
    Antiproliferative activity against human HCT116 assessed as reduction in cell viability measured after 96 hrs by MTT assay
    		[PMID: 27476419]
    HCT-116 IC50
    0.15 μM
    Compound: Geldanamycin
    Anticancer activity against human HCT116 cells measured after 72 hrs by SRB assay
    Anticancer activity against human HCT116 cells measured after 72 hrs by SRB assay
    		[PMID: 27283788]
    HeLa IC50
    > 5 μM
    Compound: Geldanamycin
    Cytotoxicity against human HeLa cells at 72 hrs by MTS assay
    Cytotoxicity against human HeLa cells at 72 hrs by MTS assay
    		[PMID: 22162786]
    HeLa IC50
    0.06 μM
    Compound: GA
    Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay
    Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay
    		[PMID: 27266997]
    HeLa IC50
    798 nM
    Compound: 1, GA
    Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
    Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
    		[PMID: 25277067]
    HepG2 IC50
    0.3 μM
    Compound: GDM
    Cytotoxicity against human HepG2 cells by MTT assay
    Cytotoxicity against human HepG2 cells by MTT assay
    		[PMID: 23656556]
    HepG2 IC50
    1.74 μM
    Compound: GM
    Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition by MTT assay
    Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition by MTT assay
    		[PMID: 32527461]
    HepG2 IC50
    40 nM
    Compound: 1, GA
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
    		[PMID: 25277067]
    Huh-7 EC50
    0.25 nM
    Compound: Geldanamycin
    Antiviral activity against Hepatitis C virus genotype 1b Con1 infected in human HuH7 cells assessed as GAPDH RNA or 18S rRNA level after 3 days by qRT-PCR analysis
    Antiviral activity against Hepatitis C virus genotype 1b Con1 infected in human HuH7 cells assessed as GAPDH RNA or 18S rRNA level after 3 days by qRT-PCR analysis
    		[PMID: 18936191]
    Huh-7 EC50
    1.2 nM
    Compound: Geldanamycin
    Antiviral activity against Hepatitis C virus genotype 1b Con1 infected in human HuH7 cells assessed as GAPDH RNA or 18S rRNA level after 3 days selected with 40 nM HCV-796 and 800 nM boceprevir by qRT-PCR analysis
    Antiviral activity against Hepatitis C virus genotype 1b Con1 infected in human HuH7 cells assessed as GAPDH RNA or 18S rRNA level after 3 days selected with 40 nM HCV-796 and 800 nM boceprevir by qRT-PCR analysis
    		[PMID: 18936191]
    HUVEC IC50
    19 nM
    Compound: 1, GA
    Cytotoxicity against HUVEC cells after 72 hrs by MTT assay
    Cytotoxicity against HUVEC cells after 72 hrs by MTT assay
    		[PMID: 25277067]
    L02 IC50
    141 nM
    Compound: 1, GA
    Cytotoxicity against human HL7702 cells after 72 hrs by MTT assay
    Cytotoxicity against human HL7702 cells after 72 hrs by MTT assay
    		[PMID: 25277067]
    L6 IC50
    6 μM
    Compound: GA
    Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay
    Cytotoxicity against rat L6 cells after 72 hrs by Alamar Blue assay
    		[PMID: 24580531]
    LNCaP IC50
    0.43 μM
    Compound: GA
    Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay
    Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay
    		[PMID: 25105924]
    LS174T IC50
    0.45 μM
    Compound: GA
    Cytotoxicity against human LS174T cells by MTS assay
    Cytotoxicity against human LS174T cells by MTS assay
    		[PMID: 17034135]
    MCF7 IC50
    0.04 μM
    Compound: GDA
    Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS/PMS assay
    Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS/PMS assay
    		[PMID: 25075762]
    MCF7 IC50
    0.0427 μM
    Compound: 1, GDA
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS/PMS assay
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS/PMS assay
    		[PMID: 25756299]
    MCF7 IC50
    0.053 μM
    Compound: Geldanamycin
    Cytotoxicity against human MCF7 cells at 72 hrs by MTS assay
    Cytotoxicity against human MCF7 cells at 72 hrs by MTS assay
    		[PMID: 22162786]
    MCF7 IC50
    0.11 μM
    Compound: 1
    Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 96 hrs by MTT assay
    Antiproliferative activity against human MCF7 assessed as reduction in cell viability measured after 96 hrs by MTT assay
    		[PMID: 27476419]
    MCF7 GI50
    35.6 μM
    Compound: geldanamycin
    Growth inhibition of human MCF7 cells after days by SRB assay
    Growth inhibition of human MCF7 cells after days by SRB assay
    		[PMID: 17869098]
    MCF7 IC50
    9.6 μM
    Compound: Geldanamycin
    Cytotoxicity against human MCF7 cells by SRB assay
    Cytotoxicity against human MCF7 cells by SRB assay
    		[PMID: 19560353]
    MCF7 IC50
    9.8 nM
    Compound: 5, GDA
    Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 72 hrs
    Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 72 hrs
    		[PMID: 23648180]
    MDA-MB-231 IC50
    0.03 μM
    Compound: GA
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay
    		[PMID: 27266997]
    MDA-MB-231 IC50
    0.05 μM
    Compound: 1, GA
    Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay
    		[PMID: 25277067]
    MDA-MB-231 IC50
    0.05 μM
    Compound: GA
    Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay
    		[PMID: 25105924]
    MDA-MB-231 IC50
    0.06 μM
    Compound: GA
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay
    		[PMID: 29172085]
    MDA-MB-231 IC50
    0.11 μM
    Compound: Geldanamycin
    Anticancer activity against human MDA-MB-231 cells measured after 72 hrs by SRB assay
    Anticancer activity against human MDA-MB-231 cells measured after 72 hrs by SRB assay
    		[PMID: 27283788]
    MDA-MB-231 IC50
    0.62 μM
    Compound: GM
    Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition by MTT assay
    		[PMID: 32527461]
    NCI-H1975 GI50
    0.56 μM
    Compound: 1; GA
    Antiproliferative activity against gefitinib-resistant human NCI-H1975 cells after 1 to 3 days by MTS assay
    Antiproliferative activity against gefitinib-resistant human NCI-H1975 cells after 1 to 3 days by MTS assay
    		[PMID: 27783977]
    NCI-H1975 GI50
    0.56 μM
    Compound: GA
    Antiproliferative activity against human NCI-H1975 cells after 72 hrs by Cell Titer 96 Aqueous One Solution cell proliferation assay
    Antiproliferative activity against human NCI-H1975 cells after 72 hrs by Cell Titer 96 Aqueous One Solution cell proliferation assay
    		[PMID: 29202402]
    P19 IC50
    0.1 μM
    Compound: 1
    Cytotoxicity against mouse P19 cells after 18 hrs
    Cytotoxicity against mouse P19 cells after 18 hrs
    		[PMID: 17442565]
    PC-3 IC50
    0.73 μM
    Compound: GDM
    Antiproliferative activity against human PC-3 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay
    Antiproliferative activity against human PC-3 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay
    		[PMID: 32663707]
    RPMI-8226 GI50
    0.003 μM
    Compound: Geldanamycin
    Growth inhibition of human RPMI8226 cells after 72 hrs by MTS/PMS assay
    Growth inhibition of human RPMI8226 cells after 72 hrs by MTS/PMS assay
    		[PMID: 29057043]
    Sf9 IC50
    74 nM
    Compound: Geldanamycin
    Displacement of GM-BODIPY from human full length HSP90 alpha expressed in baculovirus-infected Sf9 cells after 16 hrs by fluorescence polarization assay
    Displacement of GM-BODIPY from human full length HSP90 alpha expressed in baculovirus-infected Sf9 cells after 16 hrs by fluorescence polarization assay
    		[PMID: 24751441]
    SK-BR-3 GI50
    0.43 μM
    Compound: 1; GA
    Antiproliferative activity against Her2-overexpressing human SKBR3 cells after 1 to 3 days by MTS assay
    Antiproliferative activity against Her2-overexpressing human SKBR3 cells after 1 to 3 days by MTS assay
    		[PMID: 27783977]
    SK-BR-3 IC50
    0.87 μM
    Compound: GDM
    Antiproliferative activity against human SK-BR-3 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay
    Antiproliferative activity against human SK-BR-3 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay
    		[PMID: 32663707]
    SK-BR-3 IC50
    41 nM
    Compound: GDM
    Cytotoxicity against human SKBR3 cells after 72 hrs by celltiter-glo assay
    Cytotoxicity against human SKBR3 cells after 72 hrs by celltiter-glo assay
    		[PMID: 19405528]
    SK-BR-3 IC50
    8.5 nM
    Compound: 5, GDA
    Antiproliferative activity against estrogen receptor deficient human SKBR3 cells after 72 hrs
    Antiproliferative activity against estrogen receptor deficient human SKBR3 cells after 72 hrs
    		[PMID: 23648180]
    SK-OV-3 IC50
    0.94 μM
    Compound: GDM
    Antiproliferative activity against human SK-OV-3 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay
    Antiproliferative activity against human SK-OV-3 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay
    		[PMID: 32663707]
    SMMC-7721 IC50
    0.11 μM
    Compound: GM
    Antiproliferative activity against human SMMC7721 cells assessed as cell growth inhibition by MTT assay
    Antiproliferative activity against human SMMC7721 cells assessed as cell growth inhibition by MTT assay
    		[PMID: 32527461]
    SNU-638 IC50
    0.03 μM
    Compound: Geldanamycin
    Anticancer activity against human SNU638 cells measured after 72 hrs by SRB assay
    Anticancer activity against human SNU638 cells measured after 72 hrs by SRB assay
    		[PMID: 27283788]
    SW1990 IC50
    0.29 μM
    Compound: 1
    Antiproliferative activity against human SW1990 assessed as reduction in cell viability measured after 96 hrs by MTT assay
    Antiproliferative activity against human SW1990 assessed as reduction in cell viability measured after 96 hrs by MTT assay
    		[PMID: 27476419]
    SW480 IC50
    0.51 μM
    Compound: GM
    Antiproliferative activity against human SW480 cells assessed as cell growth inhibition by MTT assay
    Antiproliferative activity against human SW480 cells assessed as cell growth inhibition by MTT assay
    		[PMID: 32527461]
    SW480 IC50
    310 nM
    Compound: 1, GA
    Cytotoxicity against human SW480 cells after 72 hrs by MTT assay
    Cytotoxicity against human SW480 cells after 72 hrs by MTT assay
    		[PMID: 25277067]
    U-87MG ATCC EC50
    0.089 μM
    Compound: 1
    Antiproliferative activity against human U87 cells by luminescence assay
    Antiproliferative activity against human U87 cells by luminescence assay
    		[PMID: 21605975]
    U-87MG ATCC IC50
    0.81 μM
    Compound: GDM
    Antiproliferative activity against human U-87 MG cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay
    Antiproliferative activity against human U-87 MG cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay
    		[PMID: 32663707]
    體外研究
    (In Vitro)

    Geldanamycin 顯著延遲和降低 viperin 表達(dá)，表明 IRF3 參與 RAW264.7 細(xì)胞中的 viperin 誘導(dǎo)[1]。
    Geldanamycin 是一種苯醌安沙霉素，可防止在培養(yǎng)的原代神經(jīng)元中由氧-葡萄糖剝奪 (OGD)/zVAD 處理誘導(dǎo)的神經(jīng)元損傷。更重要的是，Geldanamycin 以時間和濃度依賴性方式降低 RIP1 蛋白水平。Geldanamycin 還會降低 Hsp90 蛋白水平，從而導(dǎo)致 RIP1 蛋白不穩(wěn)定，導(dǎo)致 Geldanamycin 處理后 RIP1 蛋白水平降低，但 RIP1 mRNA 水平?jīng)]有降低[2]。
    Geldanamycin 被確定為第一個 Hsp90 的天然產(chǎn)物抑制劑，它結(jié)合 Hsp90 的 N 端 ATPase 結(jié)構(gòu)域以抑制其分子伴侶功能，并通過凋亡機制顯著誘導(dǎo)腫瘤細(xì)胞死亡[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    560.64

    Formula

    C29H40N2O9
    CAS 號
    性狀

    固體

    顏色

    Light yellow to orange

    中文名稱

    格爾德霉素
    結(jié)構(gòu)分類
    初始來源

    Streptomyces hygroscopicus
    運輸條件

    Room temperature in continental US; may vary elsewhere.
    儲存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性數(shù)據(jù)
    細(xì)胞實驗： 

    DMSO 中的溶解度 : 25 mg/mL (44.59 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

    配制儲備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 1.7837 mL 8.9184 mL 17.8368 mL
    5 mM 0.3567 mL 1.7837 mL 3.5674 mL
    查看完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

    • 摩爾計算器

    • 稀釋計算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動物實驗：

    請根據(jù)您的 實驗動物和給藥方式 選擇適當(dāng)?shù)娜芙夥桨浮?

    以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
    ——為保證實驗結(jié)果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用；
    以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

    • 方案 一

      請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: 2.5 mg/mL (4.46 mM); 懸濁液; 超聲助溶

      此方案可獲得 2.5 mg/mL的均勻懸濁液，懸濁液可用于口服和腹腔注射。

      以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水 定容至 1 mL。

      生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
    • 方案 二

      請依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: 2.5 mg/mL (4.46 mM); 懸濁液; 超聲助溶

      此方案可獲得 2.5 mg/mL的均勻懸濁液，懸濁液可用于口服和腹腔注射。

      以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 900 μL 20% 的 SBE-β-CD 生理鹽水水溶液 中，混合均勻。

      2 g SBE-β-CD（磺丁基醚 β-環(huán)糊精）粉末定容于 10 mL 的生理鹽水中，完全溶解至澄清透明。
    動物溶解方案計算器
    請輸入動物實驗的基本信息：

    給藥劑量

    mg/kg

    動物的平均體重

    g

    每只動物的給藥體積

    μL

    動物數(shù)量

    只
    由于實驗過程有損耗，建議您多配一只動物的量
    請輸入您的動物體內(nèi)配方組成：
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    如果您的動物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。
    方案所需 助溶劑 包括：DMSO， ，均可在 MCE 網(wǎng)站選購。 ，Tween 80，均可在 MCE 網(wǎng)站選購。
    計算結(jié)果
    工作液所需濃度 : mg/mL
    儲備液配制方法 : mg 藥物溶于 μL  DMSO（母液濃度為 mg/mL）。
    您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，以下方案僅供參考，如有需要，請與 MCE 中國技術(shù)支持聯(lián)系。
    動物實驗體內(nèi)工作液的配制方法 : 取 μL DMSO 儲備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。
    連續(xù)給藥周期超過半月以上，請謹(jǐn)慎選擇該方案。
    請確保第一步儲備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱 （超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。
    純度 & 產(chǎn)品資料

    純度: 99.78%

    參考文獻(xiàn)

    完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.7837 mL 8.9184 mL 17.8368 mL 44.5919 mL
    5 mM 0.3567 mL 1.7837 mL 3.5674 mL 8.9184 mL
    10 mM 0.1784 mL 0.8918 mL 1.7837 mL 4.4592 mL
    15 mM 0.1189 mL 0.5946 mL 1.1891 mL 2.9728 mL
    20 mM 0.0892 mL 0.4459 mL 0.8918 mL 2.2296 mL
    25 mM 0.0713 mL 0.3567 mL 0.7135 mL 1.7837 mL
    30 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.4864 mL
    40 mM 0.0446 mL 0.2230 mL 0.4459 mL 1.1148 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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