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  2. Cytoskeleton
  3. Myosin
  4. JB062

JB062 是一種非肌肉肌球蛋白 (nonmuscle myosin) 抑制劑，對(duì)骨骼肌肌球蛋白、心肌肌球蛋白和平滑肌肌球蛋白 II 的 IC50 值分別為分別為 1.6、5.4 和 >100 μM。JB062 對(duì)人類癌細(xì)胞具有細(xì)胞毒性，但對(duì)正常細(xì)胞沒有細(xì)胞毒性。JB062 可用于肌肉痙攣、慢性肌肉骨骼疼痛和肥厚型心肌病的研究。

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JB062 Chemical Structure

JB062 Chemical Structure

CAS No. : 2417988-00-0

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥2210
1 - 2 周
5 mg   詢價(jià)  
10 mg   詢價(jià)  

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

JB062 is a nonmuscle myosin inhibitor with IC50 values of 1.6, 5.4, and >100 μM for Skeletal muscle myosin, Cardiac muscle myosin, and Smooth muscle myosin II, respectively. JB062 has cytotoxic to human cancer cells but not normal cells. JB062 can be used in research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy[1].

IC50 & Target

IC50: 1.6 μM (Skeletal muscle myosin), 5.4 μM (Cardiac muscle myosin), and >100 μM (Smooth muscle myosin II)[1]
體外研究
(In Vitro)

JB062 (compound 6b; 40 μM; 24 h) 抑制 COS-7 細(xì)胞的胞質(zhì)分裂[1]。
JB062 (COS-7 細(xì)胞) 對(duì)人類癌細(xì)胞具有細(xì)胞毒性，但對(duì)正常細(xì)胞沒有細(xì)胞毒性，CC10 值為 36 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

323.34

Formula

C19H17NO4
CAS 號(hào)
性狀

固體

顏色

White to off-white

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

JB062 相關(guān)分類

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

產(chǎn)品名稱：
JB062
目錄號(hào)：
HY-152206
需求量：