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  2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. CNQX disodium

CNQX disodium  (Synonyms: FG9065 disodium)

目錄號(hào): HY-15066A 純度: 99.95%
COA 產(chǎn)品使用指南 技術(shù)支持

CNQX disodium (FG9065 disodium) 是一種有效的競(jìng)爭(zhēng)性 AMPA /海藻酸酯受體 (AMPA/kainate receptor) 拮抗劑，IC50 分別為 0.3 μM 和 1.5 μM。CNQX disodium 是一種競(jìng)爭(zhēng)性的非 NMDA 受體拮抗劑。CNQX disodium 會(huì)阻止大鼠恐懼增強(qiáng)的表達(dá)。

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CNQX disodium Chemical Structure

CNQX disodium Chemical Structure

CAS No. : 479347-85-8

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規(guī)格 價(jià)格 是否有貨 數(shù)量
5 mg ￥500
In-stock
10 mg ￥700
In-stock
25 mg ￥1400
In-stock
50 mg ￥2090
In-stock
100 mg ￥3500
In-stock
200 mg   詢價(jià)  
500 mg   詢價(jià)  

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Customer Review

Other Forms of CNQX disodium:

查看 iGluR 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

CNQX disodium (FG9065 disodium) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX disodium is a competitive non-NMDA receptor antagonist[1]. CNQX disodium blocks the expression of fear-potentiated startle in rats[5].

IC50 & Target

IC50: 0.3 μM (AMPA) and 1.5 μM (kainate receptor)[1]
體外研究
(In Vitro)

CNQX disodium (FG9065 disodium; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices[2].
CNQX disodium (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

CNQX disodium (FG9065 disodium; 0.75-3 mg/kg; IP; 20 min before testing) decreased the number of cocaine responses in a dose-dependent manner during the first 15-min cocaine-free interval[4].
The bilateral infusion of CNQX disodium (0.5 or 1.25 μg) into the amygdala or dorsal hippocampus 10 min prior to a retention test partially blocks the expression of stepdown inhibitory avoidance in rats 24 h after training. CNQX disodium causes a complete blockade at a dose of 0.5 μg[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing 180-200 g[4]
Dosage: 0.75, 1.5, and 3 mg/kg
Administration: IP; 20 min before testing
Result: Decreased the number of cocaine (IV; 0.25 mg/infusion) responses in a dose-dependent manner during the first 15-min cocaine-free interval.
分子量

276.12

Formula

C9H2N4Na2O4
CAS 號(hào)
性狀

固體

顏色

Brown to red

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 10.53 mg/mL (38.14 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 70°C; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 3.6216 mL 18.1081 mL 36.2161 mL
5 mM 0.7243 mL 3.6216 mL 7.2432 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻(xiàn)

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6216 mL 18.1081 mL 36.2161 mL 90.5403 mL
5 mM 0.7243 mL 3.6216 mL 7.2432 mL 18.1081 mL
10 mM 0.3622 mL 1.8108 mL 3.6216 mL 9.0540 mL
15 mM 0.2414 mL 1.2072 mL 2.4144 mL 6.0360 mL
20 mM 0.1811 mL 0.9054 mL 1.8108 mL 4.5270 mL
25 mM 0.1449 mL 0.7243 mL 1.4486 mL 3.6216 mL
30 mM 0.1207 mL 0.6036 mL 1.2072 mL 3.0180 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
CNQX disodium
目錄號(hào)：
HY-15066A
需求量：