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  2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Rosabulin

Rosabulin  (Synonyms: STA 5312)

目錄號: HY-14934 純度: 98.72%
COA 產品使用指南 技術支持

Rosabulin (STA 5312) 是一種有效的具有口服活性的微管 (microtubule) 抑制劑，可抑制微管組裝。Rosabulin 具有廣譜抗腫瘤活性。

MCE 的所有產品僅用作科學研究或藥證申報，我們不為任何個人用途提供產品和服務

Rosabulin Chemical Structure

Rosabulin Chemical Structure

CAS No. : 501948-05-6

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2.  同一機構（單位）同一產品試用裝僅限申領一次，同一機構（單位）一年內

     可免費申領三個不同產品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 價格 是否有貨 數量
10 mM * 1 mL in DMSO ￥2731
In-stock
1 mg ￥1450
In-stock
5 mg ￥3100
In-stock
10 mg ￥4650
In-stock
25 mg 現貨 詢價
50 mg 現貨 詢價
100 mg 現貨 詢價
200 mg   詢價  
500 mg   詢價  

* Please select Quantity before adding items.

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

Rosabulin (STA 5312) is a potent and orally active microtubule inhibitor that inhibits microtubule assembly. Rosabulin has broad-spectrum anti-tumor activity[1].

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
DU-145 IC50
0.05 μM
Compound: 5b
Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
[PMID: 18308566]
HL-60 IC50
0.05 μM
Compound: 5b
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
[PMID: 18308566]
MDA-MB-435 IC50
0.05 μM
Compound: 5b
Cytotoxicity against human MDA435 cells after 72 hrs by MTT assay
Cytotoxicity against human MDA435 cells after 72 hrs by MTT assay
[PMID: 18308566]
MES-SA IC50
0.01 μM
Compound: 5b
Cytotoxicity against human MESSA cells after 72 hrs by MTT assay
Cytotoxicity against human MESSA cells after 72 hrs by MTT assay
[PMID: 18308566]
MES-SA/Dx5 IC50
0.05 μM
Compound: 5b
Cytotoxicity against human MESSA/DX5 cells after 72 hrs by MTT assay
Cytotoxicity against human MESSA/DX5 cells after 72 hrs by MTT assay
[PMID: 18308566]
P388 IC50
0.01 μM
Compound: 5b
Cytotoxicity against mouse P388 cells after 72 hrs by MTT assay
Cytotoxicity against mouse P388 cells after 72 hrs by MTT assay
[PMID: 18308566]
體外研究
(In Vitro)

Rosabulin (STA 5312) demonstrates substantial anti-proliferative activity against a wide range of cancer cell linesin vitro, including hematologic and solid tumor cell lines of various origins (e.g. leukemia, lymphoma, breast, colon, uterine), with IC50 values extending down into the nanomolar range. Cell lines with multi-drug resistant (MDR) phenotypes are similarly sensitive to Rosabulin. The mechanism of action for Rosabulin is inhibition of microtubule assembly and subsequent arrest of the cell cycle[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內研究
(In Vivo)

When dosed orally or intravenously, Rosabulin (STA 5312) has shown in vivo activity in several murine tumors as well as human tumor xenograft models, including drug resistant tumors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

400.45

Formula

C22H16N4O2S
CAS 號
性狀

固體

顏色

Light yellow to green yellow

中文名稱

羅沙布林
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數據
細胞實驗： 

DMSO 中的溶解度 : 50 mg/mL (124.86 mM; 超聲助溶; 吸濕的 DMSO 對產品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 2.4972 mL 12.4860 mL 24.9719 mL
5 mM 0.4994 mL 2.4972 mL 4.9944 mL
查看完整儲備液配制表

* 請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產品資料
參考文獻

完整儲備液配制表

* 請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4972 mL 12.4860 mL 24.9719 mL 62.4298 mL
5 mM 0.4994 mL 2.4972 mL 4.9944 mL 12.4860 mL
10 mM 0.2497 mL 1.2486 mL 2.4972 mL 6.2430 mL
15 mM 0.1665 mL 0.8324 mL 1.6648 mL 4.1620 mL
20 mM 0.1249 mL 0.6243 mL 1.2486 mL 3.1215 mL
25 mM 0.0999 mL 0.4994 mL 0.9989 mL 2.4972 mL
30 mM 0.0832 mL 0.4162 mL 0.8324 mL 2.0810 mL
40 mM 0.0624 mL 0.3121 mL 0.6243 mL 1.5607 mL
50 mM 0.0499 mL 0.2497 mL 0.4994 mL 1.2486 mL
60 mM 0.0416 mL 0.2081 mL 0.4162 mL 1.0405 mL
80 mM 0.0312 mL 0.1561 mL 0.3121 mL 0.7804 mL
100 mM 0.0250 mL 0.1249 mL 0.2497 mL 0.6243 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
Rosabulin
目錄號：
HY-14934
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