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  2. Anti-infection
  3. SARS-CoV Influenza Virus
  4. Umifenovir

Umifenovir 是一種有效的口服活性廣譜抗病毒活性分子，對(duì)許多包膜病毒和非包膜病毒具有活性。Umifenovir 被用作抗流感病毒劑 (anti-influenza virus)。Umifenovir 能有效抑制病毒與宿主細(xì)胞的融合。 Umifenovir 是體外有效的 SARS-CoV-2 的抑制劑。Umifenovir 具有抗炎活性。

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Umifenovir Chemical Structure

Umifenovir Chemical Structure

CAS No. : 131707-25-0

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥426
In-stock
5 mg ￥406
In-stock
10 mg ￥650
In-stock
25 mg ￥1073
In-stock
50 mg ￥1575
In-stock
100 mg ￥2325
In-stock
500 mg ￥5775
In-stock
1 g   詢價(jià)  
5 g   詢價(jià)  

* Please select Quantity before adding items.

Customer Review

Other Forms of Umifenovir:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is used as an anti-influenza virus agent. Umifenovir could effectively inhibit the fusion of virus with host cells[1][2]. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro[2]. Umifenovir shows anti-inflammatory activity[3].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa EC50
> 200 μM
Compound: Arbidol
Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 E572K mutant expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staini
Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 E572K mutant expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staini
[PMID: 31753804]
HeLa EC50
> 200 μM
Compound: Arbidol
Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 D1122N expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.6 by giemsa staining bas
Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 D1122N expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.6 by giemsa staining bas
[PMID: 31753804]
HeLa EC50
40 μM
Compound: Arbidol
Inhibition of influenza H3N2 A/X-31 hemagglutinin 3 expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staining based microscopic
Inhibition of influenza H3N2 A/X-31 hemagglutinin 3 expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staining based microscopic
[PMID: 31753804]
Huh-7 IC50
1 μM
Compound: Arbidol
Cytotoxicity against human Huh7.5 cells by celltiter-blue viability assay
Cytotoxicity against human Huh7.5 cells by celltiter-blue viability assay
[PMID: 20638289]
MDCK IC50
32.5 μM
Compound: Arbidol
Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect incubated for 48 hrs by crystal violet staining based assay
Antiviral activity against Influenza A virus (A/Puerto Rico/8/1934(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect incubated for 48 hrs by crystal violet staining based assay
[PMID: 32520560]
MDCK CC50
46.44 μM
Compound: arbidol
Cytotoxicity against dog MDCK cells incubated for 48 hrs by MTT assay
Cytotoxicity against dog MDCK cells incubated for 48 hrs by MTT assay
[PMID: 33631936]
MRC5 CC50
376 μM
Compound: 2
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by neutral red staining-based microscopic analysis
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 48 hrs by neutral red staining-based microscopic analysis
[PMID: 28689975]
Vero CC50
161 μM
Compound: Arbidol
Cytotoxicity against African green monkey Vero cells assessed as reduction in metabolic activity by MTS/PMS based microscopic analysis
Cytotoxicity against African green monkey Vero cells assessed as reduction in metabolic activity by MTS/PMS based microscopic analysis
[PMID: 27856239]
Vero CC50
31.79 μM
Compound: 16
Cytotoxicity against african green monkey Vero cells incubated for 3 days
Cytotoxicity against african green monkey Vero cells incubated for 3 days
[PMID: 32539378]
Vero EC50
35 μM
Compound: Arbidol
Antiviral activity against Chikungunya virus 899 infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathogenic effect measured 5 days post infection by MTS/PMS based microscopic analysis
Antiviral activity against Chikungunya virus 899 infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathogenic effect measured 5 days post infection by MTS/PMS based microscopic analysis
[PMID: 27856239]
Vero CC50
679.9 μM
Compound: 2
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 18 hrs by neutral red staining-based microscopic analysis
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 18 hrs by neutral red staining-based microscopic analysis
[PMID: 28689975]
Vero C1008 CC50
> 40 μM
Compound: Arbidol
Cytotoxicity (CC50) determination in Vero E6 cells measured by fluorescence (OD590nm)
Cytotoxicity (CC50) determination in Vero E6 cells measured by fluorescence (OD590nm)
10.1101/2020.04.03.023846
Vero C1008 EC50
10.7 μM
Compound: Arbidol
Antiviral efficacy against SARS-CoV-2 (strain BavPat1) in Vero E6 cells assessed by inhibition of viral RNA replication measured by RT-PCR after 2 days
Antiviral efficacy against SARS-CoV-2 (strain BavPat1) in Vero E6 cells assessed by inhibition of viral RNA replication measured by RT-PCR after 2 days
10.1101/2020.04.03.023846
Vero C1008 CC50
31.79 μM
Compound: Arbidol
Cytotoxicity against African green monkey Vero E6 cells assessed as cell growth inhibition by CCK8 assay
Cytotoxicity against African green monkey Vero E6 cells assessed as cell growth inhibition by CCK8 assay
[PMID: 32771797]
體外研究
(In Vitro)

Umifenovir exhibits a wide range and potent antiviral activity against a number of viruses including influenza viruses A, B and C, respiratory syncytial virus, SARS-CoV, adenovirus, parainfluenza type 5, poliovirus 1, rhinovirus 14, coxsackievirus B5, hantaan virus, Chikungunya virus, HBV and HCV[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Umifenovir (25 and 45 mg/ml; p.o.) shows a survival benefit to mice suffering from influenza infection[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice (6–8 weeks old), mice were intranasally (i.n.) inoculated with 2 times the 50% mouse lethal dose (MLD50) of A/ Guangdong/GIRD07/09 (H1N1) (104.5TCID50/mL) in a volume of 20mL[3].
Dosage: 1.25 mg/mL (25 mg/kg/day) and 2.25 mg/mL (45 mg/kg/day) in a total volume of 500mL at one day pre-infection and 3 days post-infection (dpi)
Administration: Oral administration
Result: Increased the survival rate, inhibited the decrease of body weight at 45 mg/mL and inhibited the increase of mice lung index at 25 mg/mL and 45 mg/mL comparing to virus group.
Clinical Trial
分子量

477.41

Formula

C22H25BrN2O3S
CAS 號(hào)
性狀

固體

顏色

Off-white to light yellow

中文名稱

阿比朵爾
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 50 mg/mL (104.73 mM; 超聲助溶; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響，請(qǐng)使用新開封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.0946 mL 10.4732 mL 20.9464 mL
5 mM 0.4189 mL 2.0946 mL 4.1893 mL
查看完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息：

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

只
由于實(shí)驗(yàn)過(guò)程有損耗，建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻(xiàn)

Umifenovir 相關(guān)分類

完整儲(chǔ)備液配制表

* 請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0946 mL 10.4732 mL 20.9464 mL 52.3659 mL
5 mM 0.4189 mL 2.0946 mL 4.1893 mL 10.4732 mL
10 mM 0.2095 mL 1.0473 mL 2.0946 mL 5.2366 mL
15 mM 0.1396 mL 0.6982 mL 1.3964 mL 3.4911 mL
20 mM 0.1047 mL 0.5237 mL 1.0473 mL 2.6183 mL
25 mM 0.0838 mL 0.4189 mL 0.8379 mL 2.0946 mL
30 mM 0.0698 mL 0.3491 mL 0.6982 mL 1.7455 mL
40 mM 0.0524 mL 0.2618 mL 0.5237 mL 1.3091 mL
50 mM 0.0419 mL 0.2095 mL 0.4189 mL 1.0473 mL
60 mM 0.0349 mL 0.1746 mL 0.3491 mL 0.8728 mL
80 mM 0.0262 mL 0.1309 mL 0.2618 mL 0.6546 mL
100 mM 0.0209 mL 0.1047 mL 0.2095 mL 0.5237 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Umifenovir
目錄號(hào)：
HY-14904
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