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  1. Metabolic Enzyme/Protease
  2. Cytochrome P450
  3. Talarozole (R enantiomer)

Talarozole (R enantiomer)  (Synonyms: (R)-Talarozole)

目錄號(hào): HY-14802
產(chǎn)品使用指南 技術(shù)支持

Talarozole R enantiomer是一個(gè)強(qiáng)的,有選擇性的細(xì)胞色素P450,CYP26的抑制劑。

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Talarozole (R enantiomer) Chemical Structure

Talarozole (R enantiomer) Chemical Structure

CAS No. : 870093-23-5

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規(guī)格 價(jià)格 是否有貨 數(shù)量
5 mg ¥3438
3 - 4 周
10 mg   詢價(jià)  
50 mg   詢價(jià)  

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Customer Review

Other Forms of Talarozole (R enantiomer):

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Talarozole R enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne. Target: CYP26 in vitro: Talarozole R enantiomer treatment increased the mRNA expression of CRABP2, KRT4, CYP26A1 and CYP26B1 dose dependently, and decreased theexpression of KRT2 and IL-1alpha compared with vehicle-treated skin. No mRNA change in retinol-metabolizing enzymes was obtained. There was no induction of epidermal thickness or overt skin inflammation in talarozole-treated skin. Immunofluorescence analysis confirmed an upregulation of KRT4 protein, but no upregulation of CYP26A1 and CYP26B1 expression was detected [1] [2]. in vivo: Talarozole R enantiomer slightly diffused into the skin only when dissolved in propylene glycol, isopropyl myristate or ethanol. Although only 0.1% of the dose applied was found in the skin itself after 12-24 h, this was sufficient to achieve local concentrations well above the half-maximal inhibitory concentration value for talarozole. The distribution of talarozole within the skin was investigated: 80% was located in the epidermis, while the remaining 20% was found in the dermis [3].

分子量

377.51

Formula

C21H23N5S

CAS 號(hào)
中文名稱

(R)-他拉羅唑

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn): 

DMSO 中的溶解度 : ≥ 51 mg/mL (135.10 mM; 吸濕的 DMSO 對(duì)產(chǎn)品的溶解度有顯著影響,請(qǐng)使用新開(kāi)封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.6489 mL 13.2447 mL 26.4894 mL
5 mM 0.5298 mL 2.6489 mL 5.2979 mL
查看完整儲(chǔ)備液配制表
  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

掃碼獲得
動(dòng)物溶解方案

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息:

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

由于實(shí)驗(yàn)過(guò)程有損耗,建議您多配一只動(dòng)物的量
純度 & 產(chǎn)品資料
參考文獻(xiàn)

完整儲(chǔ)備液配制表

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6489 mL 13.2447 mL 26.4894 mL 66.2234 mL
5 mM 0.5298 mL 2.6489 mL 5.2979 mL 13.2447 mL
10 mM 0.2649 mL 1.3245 mL 2.6489 mL 6.6223 mL
15 mM 0.1766 mL 0.8830 mL 1.7660 mL 4.4149 mL
20 mM 0.1324 mL 0.6622 mL 1.3245 mL 3.3112 mL
25 mM 0.1060 mL 0.5298 mL 1.0596 mL 2.6489 mL
30 mM 0.0883 mL 0.4415 mL 0.8830 mL 2.2074 mL
40 mM 0.0662 mL 0.3311 mL 0.6622 mL 1.6556 mL
50 mM 0.0530 mL 0.2649 mL 0.5298 mL 1.3245 mL
60 mM 0.0441 mL 0.2207 mL 0.4415 mL 1.1037 mL
80 mM 0.0331 mL 0.1656 mL 0.3311 mL 0.8278 mL
100 mM 0.0265 mL 0.1324 mL 0.2649 mL 0.6622 mL

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產(chǎn)品名稱:
Talarozole (R enantiomer)
目錄號(hào):
HY-14802
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