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  2. Anti-infection
  3. CMV HSV Orthopoxvirus
  4. Brincidofovir

Brincidofovir  (Synonyms: CMX001; HDP-CDV)

目錄號: HY-14532 純度: 99.00%
COA 產品使用指南 技術支持

Brincidofovir (CMX001) 是 Cidofovir 的脂質結合前體藥物，是一種口服、長效抗病毒藥物。Brincidofovir 對廣泛的 DNA 病毒具有活性，包括巨細胞病毒 (CMV)、腺病毒 (ADV)、水痘帶狀皰疹病毒、單純皰疹病毒、多瘤病毒、乳頭瘤病毒、痘病毒和混合雙鏈 DNA 病毒感染。Brincidofovir是一種具有口服活性的抗病毒化合物，已被證明在體外和體內對正痘病毒有效。

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Brincidofovir Chemical Structure

Brincidofovir Chemical Structure

CAS No. : 444805-28-1

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥960
In-stock
5 mg ￥2240
In-stock
10 mg ￥3360
In-stock
25 mg 現(xiàn)貨 詢價
50 mg   詢價  
100 mg   詢價  

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Customer Review

查看 HSV 亞型特異性產品:

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir (HY-17438), is an orally available, long-acting antiviral. Brincidofovir shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections. Brincidofovir, an oral antiviral in late stage development, has proven effective against orthopoxviruses in vitro and in vivo.[1][2][3][4].

IC50 & Target

EC50: 5.5 nM (anti-CMV, in PDA at 7 dpi)
細胞效力
(Cellular Effect)
Cell Line Type Value Description References
BSC-1 EC50
0.125 μM
Compound: 1, HDP-CDV
Antiviral activity against Ectromelia virus Moscow infected in african green monkey BSC1 cells after 4 to 5 days by plaque reduction assay
Antiviral activity against Ectromelia virus Moscow infected in african green monkey BSC1 cells after 4 to 5 days by plaque reduction assay
[PMID: 21493074]
BSC-1 CC50
25.3 μM
Compound: 1, HDP-CDV
Cytotoxicity against african green monkey BSC1 cells after 2 to 4 hrs by MTS assay
Cytotoxicity against african green monkey BSC1 cells after 2 to 4 hrs by MTS assay
[PMID: 21493074]
HFF EC50
0.08 μM
Compound: 1, HDP-CDV
Antiviral activity against Vaccinia virus Copenhagen infected in human HFF cells after 3 days by plaque reduction assay
Antiviral activity against Vaccinia virus Copenhagen infected in human HFF cells after 3 days by plaque reduction assay
[PMID: 21493074]
HFF EC50
0.13 μM
Compound: CMX001
Antiviral activity against Vaccinia virus WR in HFF cells assessed as reduction plaque formation after 3 days
Antiviral activity against Vaccinia virus WR in HFF cells assessed as reduction plaque formation after 3 days
[PMID: 17724153]
HFF EC50
0.14 μM
Compound: CMX001
Antiviral activity against Vaccinia virus Copenhagen in HFF cells assessed as reduction plaque formation after 3 days
Antiviral activity against Vaccinia virus Copenhagen in HFF cells assessed as reduction plaque formation after 3 days
[PMID: 17724153]
HFF EC50
0.2 μM
Compound: 1, HDP-CDV
Antiviral activity against Cowpox virus (Brighton Red) infected in human HFF cells after 3 days by plaque reduction assay
Antiviral activity against Cowpox virus (Brighton Red) infected in human HFF cells after 3 days by plaque reduction assay
[PMID: 21493074]
HFF EC50
0.24 μM
Compound: CMX001
Antiviral activity against Cowpox virus Brighton in HFF cells assessed as reduction plaque formation after 3 days
Antiviral activity against Cowpox virus Brighton in HFF cells assessed as reduction plaque formation after 3 days
[PMID: 17724153]
HFF EC50
0.6 μM
Compound: HDP-CDV
Antiviral activity against Cowpox virus Brighton in HFF cells assessed as reduction of viral replication after 3 days
Antiviral activity against Cowpox virus Brighton in HFF cells assessed as reduction of viral replication after 3 days
[PMID: 17846137]
HFF EC50
0.8 μM
Compound: HDP-CDV
Antiviral activity against Vaccinia virus Copenhagen in HFF cells assessed as reduction of viral replication after 3 days
Antiviral activity against Vaccinia virus Copenhagen in HFF cells assessed as reduction of viral replication after 3 days
[PMID: 17846137]
HFF EC50
1.1 μM
Compound: HDP-CDV
Antiviral activity against Vaccinia virus WR in HFF cells assessed as reduction of viral replication after 3 days
Antiviral activity against Vaccinia virus WR in HFF cells assessed as reduction of viral replication after 3 days
[PMID: 17846137]
HFF CC50
25 μM
Compound: 1, HDP-CDV
Cytotoxicity against human HFF cells assessed as reduction in cell viability after 7 days by neutral red uptake assay
Cytotoxicity against human HFF cells assessed as reduction in cell viability after 7 days by neutral red uptake assay
[PMID: 21493074]
HFF CC50
31 μM
Compound: HDP-CDV
Cytotoxicity against HFF cells after 7 days
Cytotoxicity against HFF cells after 7 days
[PMID: 17846137]
HFF CC50
42 μM
Compound: CMX001
Cytotoxicity against HFF cells after 7 days by neutral red assay
Cytotoxicity against HFF cells after 7 days by neutral red assay
[PMID: 17724153]
體內研究
(In Vivo)

Brincidofovir (BCV) (20 mg/kg；口服；在第 1、3、5、7、10、14、17、21 和 24 天) 延長 IHD-J-Luc VACV 處理的免疫缺陷 BALB/c nu/nu 小鼠的存活期[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nu/nu mice (infected with IHD-J-Luc VACV)[3]
Dosage: 20 mg/kg
Administration: P.o.; on days 1, 3, 5, 7, 10, 14, 17, 21, and 24
Result: On days 1, 3, and 5 maintained their weights initially but started to lose weight beginning on day 9 and succumbed between days 24 and 29 postchallenge.
Clinical Trial
分子量

561.69

Formula

C27H52N3O7P
CAS 號
性狀

固體

顏色

White to off-white

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 1 mg/mL (1.78 mM; adjust pH to 8 with NaOH and heat to 50°C; 吸濕的 DMSO 對產品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 1.7803 mL 8.9017 mL 17.8034 mL
5 mM --- --- ---
查看完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產品資料
參考文獻

Brincidofovir 相關分類

完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7803 mL 8.9017 mL 17.8034 mL 44.5085 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
Brincidofovir
目錄號：
HY-14532
需求量：