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  2. PROTAC
  3. PROTAC Linkers
  4. TCO-PEG4-NHS ester

TCO-PEG4-NHS ester 是一種 PROTAC linker，屬于 PEG 類?？捎糜诤铣?PROTAC 分子。TCO-PEG4-NHS ester 是一種點(diǎn)擊化學(xué)試劑。它含有 TCO 基團(tuán)，可以和含有 Tetrazine 基團(tuán)的分子發(fā)生逆電子需求 Diels-Alder 反應(yīng) (iEDDA)。

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TCO-PEG4-NHS ester Chemical Structure

TCO-PEG4-NHS ester Chemical Structure

CAS No. : 1621096-79-4

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規(guī)格 價(jià)格 是否有貨 數(shù)量
5 mg ￥750
In-stock
10 mg ￥1125
In-stock
25 mg ￥1860
In-stock
50 mg ￥2500
In-stock
100 mg ￥3400
In-stock
200 mg   詢價(jià)  
500 mg   詢價(jià)  

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Customer Review

Other Forms of TCO-PEG4-NHS ester:

查看 PROTAC Linkers 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

TCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. TCO-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

IC50 & Target

PEGs

 

體外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

514.57

Formula

C24H38N2O10
CAS 號(hào)
性狀

油狀物

顏色

Colorless to light yellow

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料
參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
TCO-PEG4-NHS ester
目錄號(hào)：
HY-141167A
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