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  2. PROTAC Antibody-drug Conjugate/ADC Related
  3. PROTAC Linkers ADC Linker
  4. Azido-PEG6-amine

Azido-PEG6-amine 是一種 PROTAC linker，屬于 PEG 類，可用于合成 PROTAC 分子。Azido-PEG6-amine 也是一種不可降解 (non-cleavable) 的含 6 個(gè)單元 PEG 的 ADC linker，可用于合成抗體偶聯(lián)活性分子 (ADC)。Azido-PEG6-amine 是一種點(diǎn)擊化學(xué)試劑。它含有 Azide 基團(tuán)，可以和含有 Alkyne 基團(tuán)的分子發(fā)生銅催化的疊氮-炔環(huán)加成反應(yīng)（CuAAc)。它還可以和含有 DBCO 或 BCN 基團(tuán)的分子發(fā)生環(huán)張力驅(qū)動(dòng)的炔-疊氮環(huán)加成反應(yīng) (SPAAC)。

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Azido-PEG6-amine Chemical Structure

Azido-PEG6-amine Chemical Structure

CAS No. : 957486-82-7

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規(guī)格 價(jià)格 是否有貨 數(shù)量
50 mg ￥355
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100 mg ￥568
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250 mg ￥666
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500 mg ￥1111
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1 g ￥1482
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5 g ￥4448
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10 g 現(xiàn)貨 詢價(jià)
50 g   詢價(jià)  

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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Azido-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-amine is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. Azido-PEG6-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target[1][2]

PEGs

 

Non-cleavable Linker

 

體外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

350.41

Formula

C14H30N4O6
CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料

純度: ≥97.0%

參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Azido-PEG6-amine
目錄號(hào)：
HY-140215
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