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  2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. QD394

QD394 是一種活性氧 (ROS) 誘導(dǎo)劑，可以誘導(dǎo)脂質(zhì)過氧化，增加細胞內(nèi)活性氧的積累，抑制 STAT3 磷酸化，誘導(dǎo)鐵死亡。

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QD394 Chemical Structure

QD394 Chemical Structure

CAS No. : 2132411-21-1

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥1691
In-stock
1 mg ￥1037
In-stock
5 mg ￥2200
In-stock
10 mg ￥3930
In-stock
25 mg 現(xiàn)貨 詢價
50 mg 現(xiàn)貨 詢價
100 mg 現(xiàn)貨 詢價
200 mg   詢價  
500 mg   詢價  

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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

QD394 is a reactive oxygen species (ROS) inducer that can induce lipid peroxidation, increase intracellular ROS accumulation, inhibit STAT3 phosphorylation, and induce ferroptosis[1].

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
BXPC-3 IC50
0.9 μM
Compound: QD394
Cytotoxicity against human BXPC-3 cells measured after 72 hrs by MTT assay
Cytotoxicity against human BXPC-3 cells measured after 72 hrs by MTT assay
[PMID: 32809827]
MIA PaCa-2 IC50
0.53 μM
Compound: QD394
Cytotoxicity against human MIA PaCa-2 cells measured after 72 hrs by MTT assay
Cytotoxicity against human MIA PaCa-2 cells measured after 72 hrs by MTT assay
[PMID: 32809827]
MIA PaCa-2 IC50
1.11 μM
Compound: QD394
Cytotoxicity against human MIA PaCa-2 cells measured after 72 hrs in presence of N-acetylcysteine by MTT assay
Cytotoxicity against human MIA PaCa-2 cells measured after 72 hrs in presence of N-acetylcysteine by MTT assay
[PMID: 32809827]
PANC-1 IC50
0.34 μM
Compound: QD394
Cytotoxicity against human PANC-1 cells measured after 72 hrs by MTT assay
Cytotoxicity against human PANC-1 cells measured after 72 hrs by MTT assay
[PMID: 32809827]
體外研究
(In Vitro)

QD394 (0-10 μM, 24 h) is cytotoxic with the IC50 values of 0.64, 0.34 and 0.9 μM for MIA PaCa-2, PANC-1 and BxPC-3 cell lines, respectively. And QD394 can inhibit the phosphorylation of STAT3 in cells and increase the phosphorylation of H2AX[1].
QD394(1-10 μM, 4 h) mediates cell death by increasing cellular ROS levels and decreases GSH/GSSG ratio in MIA PaCa-2 cells; also induces iron-dependent and GPX4-mediated ferroptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

349.39

Formula

C19H19N5O2
CAS 號
性狀

固體

顏色

Brown to black

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 5 mg/mL (14.31 mM; 超聲加熱助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.8621 mL 14.3107 mL 28.6213 mL
5 mM 0.5724 mL 2.8621 mL 5.7243 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料

純度: ≥99.0%

參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8621 mL 14.3107 mL 28.6213 mL 71.5533 mL
5 mM 0.5724 mL 2.8621 mL 5.7243 mL 14.3107 mL
10 mM 0.2862 mL 1.4311 mL 2.8621 mL 7.1553 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
QD394
目錄號：
HY-139369
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