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  2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. STAT Apoptosis
  4. Stattic

Stattic 是一種有效的 STAT3 抑制劑，可以抑制 STAT3 磷酸化 (磷酸化位點為 Y705 和 S727)。Stattic 抑制高親和力磷酸肽與 STAT3 的 SH2 域結合。Stattic 可改善 Alport 綜合征 (AS) 小鼠的腎功能不全。

MCE 的所有產(chǎn)品僅用作科學研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務

Stattic Chemical Structure

Stattic Chemical Structure

CAS No. : 19983-44-9

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥550
In-stock
5 mg ￥312
In-stock
10 mg ￥500
In-stock
25 mg ￥800
In-stock
50 mg ￥1300
In-stock
100 mg ￥2000
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200 mg   詢價  
500 mg   詢價  

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Customer Review

MCE 顧客使用本產(chǎn)品發(fā)表的 178 篇科研文獻

WB
Proliferation Assay

    Stattic purchased from MCE. Usage Cited in: Mol Med Rep. 2023 Apr;27(4):81.  [Abstract]

    Stattic (5, 15, 30 μM; 4 h) markedly inhibits Y705 STAT3 phosphorylation in both senescent TC?1 (Fig. C) and TRAMP?C2 (Fig. D) cells in a concentration?dependent manner.

    Stattic purchased from MCE. Usage Cited in: Ecotoxicol Environ Saf. 2022 Nov 11;248:114268.  [Abstract]

    Stattic (10 μM) effectively attenuates the SCCP-mediated increase in iNOS and GFAP expression in C6 cells.

    Stattic purchased from MCE. Usage Cited in: Mol Cancer. 2019 Mar 30;18(1):64.  [Abstract]

    Western blot analysis of HCT116 cells alone, IL6-supplemented HCT116, TAMs-co-cultured HCT116 in the presence or absence of Stattic (15 μM).

    Stattic purchased from MCE. Usage Cited in: Cell Signal. 2019 Mar;55:65-72.  [Abstract]

    Western blotting and densitometric analysis of p-STAT3 in Lo2 cells after 24 h of treatment with the indicated concentrations of the STAT3 inhibitor stattic.

    Stattic purchased from MCE. Usage Cited in: IUBMB Life. 2018 Jan;70(1):81-91.  [Abstract]

    A549 cells are treated with TG101348 (3 nM), BMS-911543 (1.5 nM), and Stattic (2.5 lM) for 24 h, and the conditioned media are collected and applied for tube formation assay in HUVECs.

    Stattic purchased from MCE. Usage Cited in: Mol Carcinog. 2017 Nov;56(11):2434-2445.  [Abstract]

    Cells are treated with the STAT3 inhibitor Stattic. The inhibitory action of Stattic on STAT3 phosphorylation is confirmed by Western blot.

    查看 STAT 亞型特異性產(chǎn)品:

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻

    生物活性

    Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727)[1]. Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3[2]. Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice[3].

    IC50 & Target[1][2]

    STAT3

     

    細胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    A549 IC50
    2.5 μM
    Compound: Stattic
    Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay
    		[PMID: 26396689]
    A549 IC50
    4.4 μM
    Compound: Stattic
    Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
    Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
    		[PMID: 27718470]
    ASPC1 IC50
    1.32 μM
    Compound: Stattic
    Antiproliferative activity against human AsPC1 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay
    Antiproliferative activity against human AsPC1 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay
    		[PMID: 24904966]
    DU-145 IC50
    2.5 μM
    Compound: Stattic
    Cytotoxicity against human DU145 cells assessed as growth inhibition after 48 hrs by MTT assay
    Cytotoxicity against human DU145 cells assessed as growth inhibition after 48 hrs by MTT assay
    		[PMID: 26396689]
    HCT-116 IC50
    1.08 μM
    Compound: Stattic
    Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
    Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
    		[PMID: 27718470]
    HCT-116 IC50
    2.16 μM
    Compound: Stattic
    Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 31048139]
    HEL IC50
    1.59 μM
    Compound: Stattic
    Antiproliferative activity against human HEL cells harboring JAK2 V617F mutant assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against human HEL cells harboring JAK2 V617F mutant assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 33689932]
    HepG2 IC50
    3.52 μM
    Compound: Stattic
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 31048139]
    L02 IC50
    5.2 μM
    Compound: Stattic
    Cytotoxicity against human LO2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Cytotoxicity against human LO2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 31048139]
    MCF-10A IC50
    6.11 μM
    Compound: Stattic
    Cytotoxicity against human MCF10A cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Cytotoxicity against human MCF10A cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 31048139]
    MCF7 IC50
    1.7 μM
    Compound: Stattic
    Antiproliferative activity against human MCF7 cells expressing low levels of STAT3 assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells expressing low levels of STAT3 assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 33689932]
    MCF7 IC50
    2.16 μM
    Compound: Stattic
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay
    Cytotoxicity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay
    		[PMID: 26396689]
    MCF7 IC50
    2.36 μM
    Compound: Stattic
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
    		[PMID: 27718470]
    MCF7 IC50
    3.6 μM
    Compound: Stattic
    Antiproliferative activity against ER-positive human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay
    Antiproliferative activity against ER-positive human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay
    		[PMID: 24904966]
    MCF7 IC50
    3.71 μM
    Compound: Stattic
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 31048139]
    MDA-MB-231 IC50
    1.56 μM
    Compound: Stattic
    Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by MTT assay
    Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by MTT assay
    		[PMID: 26396689]
    MDA-MB-231 IC50
    1.68 μM
    Compound: Stattic
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
    		[PMID: 27718470]
    MDA-MB-231 IC50
    1.81 μM
    Compound: Stattic
    Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
    		[PMID: 31048139]
    MDA-MB-231 IC50
    2.64 μM
    Compound: Stattic
    Antiproliferative activity against human MDA-MB-231 cells overexpressing STAT3 assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay
    Antiproliferative activity against human MDA-MB-231 cells overexpressing STAT3 assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay
    		[PMID: 32603980]
    MDA-MB-231 IC50
    2.89 μM
    Compound: Stattic
    Antiproliferative activity against ER-negative and triple-negative human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay
    Antiproliferative activity against ER-negative and triple-negative human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay
    		[PMID: 24904966]
    MDA-MB-435S IC50
    1.87 μM
    Compound: Stattic
    Cytotoxicity against human MDA-MB-435S cells assessed as growth inhibition after 48 hrs by MTT assay
    Cytotoxicity against human MDA-MB-435S cells assessed as growth inhibition after 48 hrs by MTT assay
    		[PMID: 26396689]
    MDA-MB-453 IC50
    4.4 μM
    Compound: Stattic
    Antiproliferative activity against human MDA-MB-453 cells expressing low levels of STAT3 assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-453 cells expressing low levels of STAT3 assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 33689932]
    MDA-MB-468 IC50
    1.92 μM
    Compound: Stattic
    Antiproliferative activity against human MDA-MB-468 cells overexpressing STAT3 assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay
    Antiproliferative activity against human MDA-MB-468 cells overexpressing STAT3 assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay
    		[PMID: 32603980]
    MDA-MB-468 IC50
    1.92 μM
    Compound: Stattic
    Antiproliferative activity against human MDA-MB-468 cells overexpressing STAT3 assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    Antiproliferative activity against human MDA-MB-468 cells overexpressing STAT3 assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
    		[PMID: 33689932]
    PANC-1 IC50
    2.9 μM
    Compound: Stattic
    Cytotoxicity against human PANC1 cells assessed as growth inhibition after 48 hrs by MTT assay
    Cytotoxicity against human PANC1 cells assessed as growth inhibition after 48 hrs by MTT assay
    		[PMID: 26396689]
    PANC-1 IC50
    3.77 μM
    Compound: Stattic
    Antiproliferative activity against human PANC1 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay
    Antiproliferative activity against human PANC1 cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay
    		[PMID: 24904966]
    體外研究
    (In Vitro)

    Stattic (20 μM；24 小時) 抑制 STAT3 磷酸化 (Y705) 并選擇性抑制 P-STAT3，正如在 Panc-1 和 HPAC 胰腺癌細胞系的 ALDH+ 和 D44+/CD24+ 亞群中，缺乏對 P-ERK1/2 的抑制所證明的那樣[1]。
    Stattic (2.5、5、10 μM；4 小時) 在 10 μM 時顯著降低 PC3M-1E8 細胞中 pSTAT3 和存活蛋白的核水平。Stattic (2.5-10 μM；24 小時) 以劑量依賴性方式抑制 IL-6 誘導的 STAT3 激活[2]。
    Stattic (2.5，5，10 μM；48 小時) 在 10 μM 時抑制前列腺癌細胞 (PC3M-1E8 細胞) 的生長并誘導其凋亡。Stattic 在 2.5 μM、5 μM 時不會誘導顯著的細胞凋亡[2]。
    Stattic (2.5，5，10 μM；48 小時) 顯示出顯著的 S 期積累[2]。
    Stattic 在 A2780 細胞和 HUVEC 細胞中不會導致顯著的形態(tài)學改變或細胞凋亡，并且導致 STAT3 磷酸化水平很低[2]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    體內(nèi)研究
    (In Vivo)

    Stattic (10 mg/kg；腹腔注射；每周 3 次，持續(xù) 10 周) 改善 Alport 綜合征 (AS) 小鼠的腎功能障礙[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Age-matched wild-type (WT) C57BL/6 mice[3]
    Dosage: 10 mg/kg
    Administration: IP; three timesper week for 10 week
    Result: Increased levels of proteinuria, BUN and serum creatinine.
    Significantly suppressed the gene expression levels of renal injury markers (Lcn2, Kim-1), pro-inflammatory cytokines (Il-6, KC), pro-fibrotic genes (Tgf-β, Col1a1, α-Sma) and Mmp9.
    分子量

    211.19

    Formula

    C8H5NO4S
    CAS 號
    性狀

    固體

    顏色

    Off-white to yellow

    運輸條件

    Room temperature in continental US; may vary elsewhere.
    儲存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    溶解性數(shù)據(jù)
    細胞實驗： 

    DMSO 中的溶解度 : 50 mg/mL (236.75 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

    配制儲備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 4.7351 mL 23.6754 mL 47.3507 mL
    5 mM 0.9470 mL 4.7351 mL 9.4701 mL
    查看完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

    • 摩爾計算器

    • 稀釋計算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動物實驗：

    請根據(jù)您的 實驗動物和給藥方式 選擇適當?shù)娜芙夥桨浮?

    以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：
    ——為保證實驗結果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當天使用；
    以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

    • 方案 一

      請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (11.84 mM); 澄清溶液

      此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液。

      以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 400 μL PEG300 中，混合均勻；再向上述體系中加入 50 μL Tween-80，混合均勻；然后再繼續(xù)加入 450 μL 生理鹽水 定容至 1 mL。

      生理鹽水的配制：將 0.9 g 氯化鈉，溶解于 ddH?O 并定容至 100 mL，可以得到澄清透明的生理鹽水溶液。
    • 方案 二

      請依序添加每種溶劑： 10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (11.84 mM); 澄清溶液

      此方案可獲得 ≥ 2.5 mg/mL（飽和度未知）的澄清溶液，此方案實驗周期在半個月以上的動物實驗酌情使用。

      以 1 mL 工作液為例，取 100 μL 25.0 mg/mL 的澄清 DMSO 儲備液加到 900 μL玉米油中，混合均勻。

    以下溶解方案，請直接配制工作液。建議現(xiàn)用現(xiàn)配，在短期內(nèi)盡快用完。 以下溶劑前顯示的百分比是指該溶劑在您配制終溶液中的體積占比； 如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶。

    • 方案 一

      請依序添加每種溶劑： 50% PEG300    50% Saline

      Solubility: 1.67 mg/mL (7.91 mM); 懸濁液; 超聲助溶

    動物溶解方案計算器
    請輸入動物實驗的基本信息：

    給藥劑量

    mg/kg

    動物的平均體重

    g

    每只動物的給藥體積

    μL

    動物數(shù)量

    只
    由于實驗過程有損耗，建議您多配一只動物的量
    請輸入您的動物體內(nèi)配方組成：
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    如果您的動物是免疫缺陷鼠或者體弱鼠，建議 DMSO 中的在最后工作液體系中的占比盡量不超過 2%。
    方案所需 助溶劑 包括：DMSO， ，均可在 MCE 網(wǎng)站選購。 ，Tween 80，均可在 MCE 網(wǎng)站選購。
    計算結果
    工作液所需濃度 : mg/mL
    儲備液配制方法 : mg 藥物溶于 μL  DMSO（母液濃度為 mg/mL）。
    您所需的儲備液濃度超過該產(chǎn)品的實測溶解度，以下方案僅供參考，如有需要，請與 MCE 中國技術支持聯(lián)系。
    動物實驗體內(nèi)工作液的配制方法 : 取 μL DMSO 儲備液，加入 μL 。 μL ，混合均勻至澄清，再加 μL Tween 80，混合均勻至澄清，再加 μL 生理鹽水。
    連續(xù)給藥周期超過半月以上，請謹慎選擇該方案。
    請確保第一步儲備液溶解至澄清狀態(tài)，從左到右依次添加助溶劑。您可采用超聲加熱 （超聲清洗儀，建議頻次 20-40 kHz），渦旋吹打等方式輔助溶解。
    純度 & 產(chǎn)品資料

    純度: 99.60%

    參考文獻

    完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C儲存時，請在2年內(nèi)使用， -20°C儲存時，請在1年內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 4.7351 mL 23.6754 mL 47.3507 mL 118.3768 mL
    5 mM 0.9470 mL 4.7351 mL 9.4701 mL 23.6754 mL
    10 mM 0.4735 mL 2.3675 mL 4.7351 mL 11.8377 mL
    15 mM 0.3157 mL 1.5784 mL 3.1567 mL 7.8918 mL
    20 mM 0.2368 mL 1.1838 mL 2.3675 mL 5.9188 mL
    25 mM 0.1894 mL 0.9470 mL 1.8940 mL 4.7351 mL
    30 mM 0.1578 mL 0.7892 mL 1.5784 mL 3.9459 mL
    40 mM 0.1184 mL 0.5919 mL 1.1838 mL 2.9594 mL
    50 mM 0.0947 mL 0.4735 mL 0.9470 mL 2.3675 mL
    60 mM 0.0789 mL 0.3946 mL 0.7892 mL 1.9729 mL
    80 mM 0.0592 mL 0.2959 mL 0.5919 mL 1.4797 mL
    100 mM 0.0474 mL 0.2368 mL 0.4735 mL 1.1838 mL
    Help & FAQs
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    產(chǎn)品名稱：
    Stattic
    目錄號：
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