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  2. GPCR/G Protein Neuronal Signaling PI3K/Akt/mTOR
  3. Dopamine Receptor Akt
  4. Quinagolide hydrochloride

Quinagolide hydrochloride  (Synonyms: 鹽酸喹高利特; CV205-502 hydrochloride)

目錄號: HY-13736A
產(chǎn)品使用指南

Quinagolide hydrochloride (CV205-502 hydrochloride) 是選擇性的、具有口服活性的多巴胺 D2 受體 激動劑。Quinagolide hydrochloride 是催乳素抑制劑。Quinagolide hydrochloride 下調(diào) AKT 的水平及其磷酸化。Quinagolide hydrochloride 具有抗腫瘤活性，可用于癌癥的研究。

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Quinagolide hydrochloride Chemical Structure

Quinagolide hydrochloride Chemical Structure

CAS No. : 94424-50-7

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥1250
In-stock
5 mg ￥2800
In-stock
10 mg ￥4100
In-stock
50 mg   詢價  
100 mg   詢價  

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Customer Review

Other Forms of Quinagolide hydrochloride:

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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Quinagolide hydrochloride (CV205-502 hydrochloride) is a selective and orally active dopamine D2 receptor agonist. Quinagolide hydrochloride is an inhibitor of prolactin. Quinagolide hydrochloride down-regulates AKT levels and its phosphorylation. Quinagolide hydrochloride shows antitumor effects, it can be used for the research of cancer[1][2].

體外研究
(In Vitro)

Quinagolide hydrochloride (100 nM; 48 h) reduces non-ergot dopamine receptor 2 (DRD2) mRNA expression in ectopic lines[2].
Quinagolide hydrochloride (100 nM; 48 h) inhibits the invasive properties of endometrial mesenchymal stromal cells (E-MSCs)[2].
Quinagolide hydrochloride (100 nM; 24 h) significantly reduces the endothelial differentiation of E-MSCs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: Eutopic and ectopic E-MSCs
Concentration: 100 nM
Incubation Time: 24 h
Result: Reduced total AKT levels in ectopic E-MSCs and significantly decreased AKT phosphorylation in both eutopic and ectopic cell lines.
體內(nèi)研究
(In Vivo)

Quinagolide hydrochloride (0.03-0.6 mg/kg; s.c. once daily for 2 month) effectively inhibits tumor growth in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Wistar-Furth rats bearing SMtTW tumors[1]
Dosage: 0.03-0.6 mg/kg
Administration: Subcutaneous injection; 0.03-0.6 mg/kg once daily for 2 month
Result: Induced normalization of plasma PRL levels in all animals, reduced the tumor size compared with the control group at a dose of 0.3 mg/kg. Showed maximal inhibitory effects on PRL secretion and tumor growth at a dose of 0.3 mg/kg.
Clinical Trial
分子量

432.02

Formula

C20H34ClN3O3S
CAS 號
性狀

固體

顏色

White to off-white

中文名稱

鹽酸喹高利特
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 3.85 mg/mL (8.91 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.3147 mL 11.5735 mL 23.1471 mL
5 mM 0.4629 mL 2.3147 mL 4.6294 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結(jié)果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3147 mL 11.5735 mL 23.1471 mL 57.8677 mL
5 mM 0.4629 mL 2.3147 mL 4.6294 mL 11.5735 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Quinagolide hydrochloride
目錄號：
HY-13736A
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