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  2. 誘導(dǎo)疾病模型產(chǎn)品 Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein Autophagy
  3. 心血管系統(tǒng)疾病模型 Endogenous Metabolite Adrenergic Receptor Autophagy
  4. 心臟疾病模型
  5. Norepinephrine tartrate

Norepinephrine tartrate  (Synonyms: 去甲腎上腺素酒石酸鹽; Levarterenol tartrate; L-Noradrenaline tartrate)

目錄號(hào): HY-13715C 純度: 99.45%
COA 產(chǎn)品使用指南

Norepinephrine (Levarterenol; L-Noradrenaline) tartrate 是一種有效的腎上腺素能受體 (AR) 激動(dòng)劑。Norepinephrine tartrate 可以激活 α1、α2、β1 受體。

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Norepinephrine tartrate Chemical Structure

Norepinephrine tartrate Chemical Structure

CAS No. : 51-40-1

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Other Forms of Norepinephrine tartrate:

MCE 顧客使用本產(chǎn)品發(fā)表的 35 篇科研文獻(xiàn)

IF
WB

    Norepinephrine tartrate purchased from MCE. Usage Cited in: Cardiovasc Res. 2018 Feb 1;114(2):300-311.  [Abstract]

    Knockdown of GATA4 ameliorated morphology and functional changes in a Meox1 cell line with NE stimulation. Immunodetection of actin in HL-1 cells. Actin staining appeared green, and sections are counterstained blue with DAPI (40,6-diamidino-2-phenylindole).

    Norepinephrine tartrate purchased from MCE. Usage Cited in: J Nutr Biochem. 2018 May 1;58:110-118.  [Abstract]

    PASMCs are pretreated with or not Norepinephrine (50 μM) or ICI 118,551 (5 nM), and α-SMA (D) are analyzed.

    查看 Adrenergic Receptor 亞型特異性產(chǎn)品:

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is a potent adrenergic receptor (AR) agonist. Norepinephrine tartrate activates α1, α2, β1 receptors[1][2][3][4].

    IC50 & Target[1]

    α1-adrenergic receptor

     

    α2-adrenergic receptor

     

    Beta-1 adrenergic receptor

     

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    細(xì)胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    CHO EC50
    1019 nM
    Compound: noradrenaline
    Agonist activity at human alpha1L-adrenoceptor expressed in CHO cells co-expressing CRELD1alpha assessed as induction of calcium mobilization after 60 mins by fluorometric imaging plate reader assay
    Agonist activity at human alpha1L-adrenoceptor expressed in CHO cells co-expressing CRELD1alpha assessed as induction of calcium mobilization after 60 mins by fluorometric imaging plate reader assay
    		[PMID: 26087939]
    體外研究
    (In Vitro)

    Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is generally considered to be a β1-subtype selective adrenergic agonist over β2-adrenoceptor. Norepinephrine(NE) tartrate also has direct activity at the β2-adrenoceptor in higher concentrations[2].
    Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 μM) with or without CGP (10 nM) co-treatment.
    Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect
    Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    RT-PCR[2]

    Cell Line: Subcutaneous preadipocytes Adipocytes.
    Concentration: 10 μM.
    Incubation Time: 6 hours.
    Result: AT2 activation suppressed Norepinephrine induced UCP1 in white adipocytes (iWA)
    體內(nèi)研究
    (In Vivo)

    誘導(dǎo)心肌病[5][6]

    致病原理
    Norepinephrine 是心肌細(xì)胞的一種強(qiáng)效生長(zhǎng)因子，通過(guò)在動(dòng)物體內(nèi)長(zhǎng)期輸注亞高壓劑量的Norepinephrine 可引起心肌質(zhì)量和左心室壁厚度的增加。Norepinephrine 通過(guò) α1 和 β腎上腺素能刺激激活 raf-1 激酶/MAP 激酶級(jí)聯(lián)，來(lái)自兩個(gè)受體的信號(hào)通路協(xié)同誘導(dǎo)心肌細(xì)胞肥大。
    具體造模方法
    Rat: Spragues-Dawley rats • adult (6 months old) • Male &bull.
    Administration: Each rat was continuously injected with 100 μg/kg/h (Norepinephrine; HY-13715) or 200 μg/kg/h (Norepinephrine; HY-13715) through an osmotic minipump.
    造模成功指標(biāo)
    分子變化：顯著增加左心室 Dnmt活性和Dnmt1、3a 和 3b 的表達(dá)。
    顯著增加左心室中胎兒基因 ANP、BNP 和 βMHC 的 mRNA 表達(dá)。
    顯著增加左心室 ROS 生成并以濃度依賴方式增加整體基因組 DNA 甲基化和左心室 PKCε 啟動(dòng)子區(qū)域 Egr-1 結(jié)合位點(diǎn)基因特異性 CpG 甲基化。
    以濃度依賴性方式增加乳酸脫氫酶釋放。
    顯著降低左心室發(fā)育壓力和 dP/dtmax、誘導(dǎo)了肌營(yíng)養(yǎng)蛋白的上調(diào)和四加半LIM域蛋白2 (FHL2) 的下調(diào)。
    表型觀測(cè)：增加心肌梗死面積并持續(xù)升高血壓。
    誘導(dǎo)心臟肥厚和心臟收縮力降低。
    增加左心室體重。
    拮抗產(chǎn)品 5-Aza-2’-deoxycytidine (HY-A0004), Prazosin (HY-B0193), Propranolol (HY-B0573B)

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    分子量

    319.26

    Formula

    C12H17NO9
    CAS 號(hào)
    性狀

    固體

    顏色

    White to off-white

    中文名稱

    去甲腎上腺素酒石酸鹽
    結(jié)構(gòu)分類
    初始來(lái)源
    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲(chǔ)存方式

    4°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

    純度 & 產(chǎn)品資料
    參考文獻(xiàn)

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    產(chǎn)品名稱：
    Norepinephrine tartrate
    目錄號(hào)：
    HY-13715C
    需求量：