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  2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. STAT Apoptosis
  4. 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea 

目錄號: HY-136658 純度: 98.02%
COA 產品使用指南 技術支持

STAT3-IN-7 是一種 Sorafenib 的衍生物，可有效抑制 STAT3 的磷酸化。STAT3-IN-7 通過依賴 SHP-1 的 STAT3 失活誘導細胞凋亡 (apoptosis)，不抑制激酶活性，并具有抗癌作用。

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1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea Chemical Structure

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea Chemical Structure

CAS No. : 1313019-65-6

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥1530
In-stock
5 mg ￥2970
In-stock
10 mg ￥4680
In-stock
25 mg 現(xiàn)貨 詢價
50 mg 現(xiàn)貨 詢價
100 mg 現(xiàn)貨 詢價
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Customer Review

MCE 顧客使用本產品發(fā)表的 1 篇科研文獻

查看 STAT 亞型特異性產品:

  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

STAT3-IN-7 is a Sorafenib analogue and potently inhibits the phosphorylation of STAT3. STAT3-IN-7 induces cell apoptosis through SHP-1 dependent STAT3 inactivation. STAT3-IN-7 does not inhibit kinase activity and has anticancer effects[1].

IC50 & Target[1]

p-STAT3

 

體外研究
(In Vitro)

STAT3-IN-7 (SC-1; 1-10 μM; 48 hours; breast cancer cells) treatment demonstrates dose-dependent suppression of cell viability in all tested breast cancer cells[1].
STAT3-IN-7 (SC-1; 1-10 μM; 36 hours; breast cancer cells) treatment induces potent apoptotic activity[1].
STAT3-IN-7 (SC-1; 1-10 μM; 36 hours; breast cancer cells) treatment shows downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells
Concentration: 1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM
Incubation Time: 48 hours
Result: Demonstrated dose-dependent suppression of cell viability in all tested breast cancer cells.

Apoptosis Analysis[1]

Cell Line: HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells
Concentration: 1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM
Incubation Time: 36 hours
Result: Induced potent apoptotic activity.

Western Blot Analysis[1]

Cell Line: HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells
Concentration: 1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM
Incubation Time: 36 hours
Result: Showed downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines.
體內研究
(In Vivo)

STAT3-IN-7 (10 mg/kg; oral gavage; daily; for 28 days; female NCr athymic nude mice) treatment shows efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NCr athymic nude mice (4-6 weeks of age) injected with breast cancer cells [1]
Dosage: 10 mg/kg
Administration: Oral gavage; daily; for 28 days
Result: Showed efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors.
分子量

431.80

Formula

C21H13ClF3N3O2
CAS 號
性狀

固體

顏色

White to off-white

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 250 mg/mL (578.97 mM; 超聲助溶; 吸濕的 DMSO 對產品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質量 1 mg 5 mg 10 mg
1 mM 2.3159 mL 11.5794 mL 23.1589 mL
5 mM 0.4632 mL 2.3159 mL 4.6318 mL
查看完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

mg/kg

動物的平均體重

g

每只動物的給藥體積

μL

動物數(shù)量

只
由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產品資料
參考文獻

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea 相關分類

完整儲備液配制表

* 請根據(jù)產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內使用，-20°C儲存時，請在1個月內使用。

可選溶劑 濃度 溶劑體積 質量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3159 mL 11.5794 mL 23.1589 mL 57.8972 mL
5 mM 0.4632 mL 2.3159 mL 4.6318 mL 11.5794 mL
10 mM 0.2316 mL 1.1579 mL 2.3159 mL 5.7897 mL
15 mM 0.1544 mL 0.7720 mL 1.5439 mL 3.8598 mL
20 mM 0.1158 mL 0.5790 mL 1.1579 mL 2.8949 mL
25 mM 0.0926 mL 0.4632 mL 0.9264 mL 2.3159 mL
30 mM 0.0772 mL 0.3860 mL 0.7720 mL 1.9299 mL
40 mM 0.0579 mL 0.2895 mL 0.5790 mL 1.4474 mL
50 mM 0.0463 mL 0.2316 mL 0.4632 mL 1.1579 mL
60 mM 0.0386 mL 0.1930 mL 0.3860 mL 0.9650 mL
80 mM 0.0289 mL 0.1447 mL 0.2895 mL 0.7237 mL
100 mM 0.0232 mL 0.1158 mL 0.2316 mL 0.5790 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea
目錄號：
HY-136658
需求量：