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  2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor NF-κB
  3. Glucocorticoid Receptor NF-κB
  4. 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione 

目錄號: HY-136340 純度: 99.93%
COA 產(chǎn)品使用指南 技術支持

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione 是 delta 9,11 類固醇類合成的中間體 (intermediate)，如 Vamorolone?(HY-109017)。delta 9,11 steroids 是糖皮質(zhì)激素的修飾后的產(chǎn)物，具有抗炎 (anti-inflammatory) 特性。delta 9,11 類固醇類可以用作保護細胞損傷(脂質(zhì)過氧化)和抑制新生血管的試劑。

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21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione Chemical Structure

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione Chemical Structure

CAS No. : 37413-91-5

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥550
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5 mg ￥312
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10 mg ￥500
In-stock
25 mg ￥1000
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查看 NF-κB 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate of delta 9,11 steroids synthesis, for example, Vamorolone?(HY-109017). The delta 9,11 steroids are modifications of glucocorticoids and has anti-inflammatory properties. The delta 9,11 steroids are agents for protection against cell damage (lipid peroxidation) and inhibition of neovascularization[1].

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
C2C12 EC50
9.36 x 10-2 μM
Compound: VBP5
Inhibition of TNFalpha-induced NFkappaB activation in mouse C2C12 cells incubated for 24 hrs prior to TNFalpha induction measured after 24 hrs by luciferase reporter gene assay
Inhibition of TNFalpha-induced NFkappaB activation in mouse C2C12 cells incubated for 24 hrs prior to TNFalpha induction measured after 24 hrs by luciferase reporter gene assay
[PMID: 23498916]
體外研究
(In Vitro)

Δ9,11 derivatives are designed and developed to stably incorporate into cell membranes and inhibit lipid peroxidation without glucocorticoid or mineralocorticoid activities, thus avoiding side effects associated with traditional corticosteroids[1].
VBP15 acts as a lead compound due to potent NF-κB inhibition and GR translocation similar to prednisone and dexamethasone, lack of transactivation properties, and good bioavailability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

366.45

Formula

C23H26O4
CAS 號
性狀

固體

顏色

White to off-white

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 100 mg/mL (272.89 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.7289 mL 13.6444 mL 27.2889 mL
5 mM 0.5458 mL 2.7289 mL 5.4578 mL
查看完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

  • 摩爾計算器

  • 稀釋計算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動物溶解方案計算器
請輸入動物實驗的基本信息：

給藥劑量

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動物的平均體重

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每只動物的給藥體積

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動物數(shù)量

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由于實驗過程有損耗，建議您多配一只動物的量
計算結果
工作液所需濃度 : mg/mL
純度 & 產(chǎn)品資料
參考文獻

完整儲備液配制表

* 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7289 mL 13.6444 mL 27.2889 mL 68.2221 mL
5 mM 0.5458 mL 2.7289 mL 5.4578 mL 13.6444 mL
10 mM 0.2729 mL 1.3644 mL 2.7289 mL 6.8222 mL
15 mM 0.1819 mL 0.9096 mL 1.8193 mL 4.5481 mL
20 mM 0.1364 mL 0.6822 mL 1.3644 mL 3.4111 mL
25 mM 0.1092 mL 0.5458 mL 1.0916 mL 2.7289 mL
30 mM 0.0910 mL 0.4548 mL 0.9096 mL 2.2741 mL
40 mM 0.0682 mL 0.3411 mL 0.6822 mL 1.7056 mL
50 mM 0.0546 mL 0.2729 mL 0.5458 mL 1.3644 mL
60 mM 0.0455 mL 0.2274 mL 0.4548 mL 1.1370 mL
80 mM 0.0341 mL 0.1706 mL 0.3411 mL 0.8528 mL
100 mM 0.0273 mL 0.1364 mL 0.2729 mL 0.6822 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione
目錄號：
HY-136340
需求量：