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  2. PROTAC Antibody-drug Conjugate/ADC Related
  3. PROTAC Linkers ADC Linker
  4. Bis-PEG13-NHS ester

Bis-PEG13-NHS ester 是一種 PROTAC 連接橋，屬于 PEG 類和 Alkyl/ether 類。Bis-PEG13-NHS ester 可用于合成一系列 PROTAC 分子。Bis-PEG13-NHS ester 是一種可降解 (cleavable) 的 ADC 連接橋，用于抗體活性分子結合物 (ADCs) 的合成。

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Bis-PEG13-NHS ester Chemical Structure

Bis-PEG13-NHS ester Chemical Structure

CAS No. : 2221949-00-2

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規(guī)格 價格 是否有貨 數量
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5 mg ￥155
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10 mg ￥230
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25 mg ￥360
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50 mg ￥523
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100 mg ￥786
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250 mg ￥1334
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1 g ￥3600
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  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

Bis-PEG13-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG13-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

PEGs

 

Alkyl/ether

 

Cleavable Linker

 

體外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

884.92

Formula

C38H64N2O21
CAS 號
性狀

固液混合物

顏色

Colorless to off-white

運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

純度 & 產品資料

純度: ≥98.0%

參考文獻

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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產品名稱：
Bis-PEG13-NHS ester
目錄號：
HY-130825
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