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  2. PI3K/Akt/mTOR Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Apoptosis Autophagy
  3. Akt Reactive Oxygen Species Apoptosis Autophagy
  4. Isobavachalcone

Isobavachalcone  (Synonyms: 補(bǔ)骨脂乙素; Corylifolinin; Isobacachalcone)

目錄號: HY-13065 純度: 99.01%
COA 產(chǎn)品使用指南 技術(shù)支持

Isobavachalcone (Corylifolinin) 來源于補(bǔ)骨脂，是一種 Akt 信號通路的有效抑制劑，可誘導(dǎo)人類癌細(xì)胞凋亡 (以 IC50 值為 7.92 μM 抑制 OVCAR-8 癌細(xì)胞生長)，具有抗癌和抗增殖活性。Isobavachalcone 還能誘導(dǎo) OVCAR-8 細(xì)胞中活性氧的產(chǎn)生。

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Isobavachalcone Chemical Structure

Isobavachalcone Chemical Structure

CAS No. : 20784-50-3

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥924
In-stock
1 mg ￥320
In-stock
5 mg ￥804
In-stock
10 mg ￥1413
In-stock
25 mg ￥2863
In-stock
50 mg ￥3660
In-stock
100 mg ￥5400
In-stock
200 mg   詢價  
500 mg   詢價  

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Customer Review

Other Forms of Isobavachalcone:

    Isobavachalcone purchased from MCE. Usage Cited in: Int Immunopharmacol. 2013 Jan;15(1):38-41.  [Abstract]

    IBC inhibits iNOS protein induced by TLRs agonists. A–C) RAW264.7 cells are pretreated with 20 or 50 μM IBC for 1 h and then further stimulated with MALP-2 (10 μg/mL) (A), LPS (10 μg/mL) (B), or poly[I:C] (10 μg/mL) (C) for an additional 8 h. Cell lysates are analyzed for iNOS and β-actin protein by immunoblots. Veh, vehicle; IBC, isobavachalcone.

    查看 Akt 亞型特異性產(chǎn)品:

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity[1].

    IC50 & Target

    IC50: 7.92 μM (OVCAR-8 cell)[1]
    細(xì)胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    A549 IC50
    > 10 μM
    Compound: 8
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    Cytotoxicity against human A549 cells after 48 hrs by MTT assay
    		[PMID: 25710081]
    HUVEC IC50
    > 100 μM
    Compound: 1c
    Toxicity against HUVEC incubated for 48 hrs by MTT assay
    Toxicity against HUVEC incubated for 48 hrs by MTT assay
    		[PMID: 25590864]
    K562 IC50
    > 10 μM
    Compound: 8
    Cytotoxicity against human K562 cells after 48 hrs by MTT assay
    Cytotoxicity against human K562 cells after 48 hrs by MTT assay
    		[PMID: 25710081]
    K562 IC50
    29.49 μM
    Compound: 1c
    Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay
    Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay
    		[PMID: 25590864]
    OVCAR-8 IC50
    7.92 μM
    Compound: 60; IBC
    Cytotoxicity against human OVCAR-8 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
    Cytotoxicity against human OVCAR-8 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
    		[PMID: 35151222]
    PC-3 IC50
    15.06 μM
    Compound: 60; IBC
    Cytotoxicity against human PC3 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
    Cytotoxicity against human PC3 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
    		[PMID: 35151222]
    Platelet IC50
    0.5 μM
    Compound: 1
    Antiplatelet activity against rabbit platelet assessed as inhibition of arachidonic acid-induced platelet aggregation preincubated for 3 mins by turbidimetric method
    Antiplatelet activity against rabbit platelet assessed as inhibition of arachidonic acid-induced platelet aggregation preincubated for 3 mins by turbidimetric method
    		[PMID: 8759164]
    Platelet IC50
    41.6 μM
    Compound: 1
    Antiplatelet activity against rabbit platelet assessed as inhibition of platelet-activating factor-induced platelet aggregation preincubated for 3 mins by turbidimetric method
    Antiplatelet activity against rabbit platelet assessed as inhibition of platelet-activating factor-induced platelet aggregation preincubated for 3 mins by turbidimetric method
    		[PMID: 8759164]
    Platelet IC50
    65.1 μM
    Compound: 1
    Antiplatelet activity against rabbit platelet assessed as inhibition of collagen-induced platelet aggregation preincubated for 3 mins by turbidimetric method
    Antiplatelet activity against rabbit platelet assessed as inhibition of collagen-induced platelet aggregation preincubated for 3 mins by turbidimetric method
    		[PMID: 8759164]
    RAW264.7 IC50
    16.4 μM
    Compound: 2
    Cytotoxicity against mouse RAW264.7 cells by MTT assay
    Cytotoxicity against mouse RAW264.7 cells by MTT assay
    		[PMID: 16643064]
    RAW264.7 IC50
    6.4 μM
    Compound: 2
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite accumulation after 20 hrs
    Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite accumulation after 20 hrs
    		[PMID: 16643064]
    THP-1 CC50
    35.95 μM
    Compound: 1
    Cytotoxicity against human THP1 cells assessed as cell viability after 72 hrs by MTT assay
    Cytotoxicity against human THP1 cells assessed as cell viability after 72 hrs by MTT assay
    		[PMID: 26906638]
    Vero IC50
    31.25 μg/mL
    Compound: 14, 4-hydroxy-isocordoin
    Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell growth after 72 hrs by MTT assay
    Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell growth after 72 hrs by MTT assay
    		[PMID: 22169259]
    Vero CC50
    726.82 μg/mL
    Compound: 14, 4-hydroxy-isocordoin
    Cytotoxicity against african green monkey Vero cells assessed as cell death after 72 hrs by MTT assay
    Cytotoxicity against african green monkey Vero cells assessed as cell death after 72 hrs by MTT assay
    		[PMID: 22169259]
    體外研究
    (In Vitro)

    Isobavachalcone (6.0-48.0 μM；72 小時；OVCAR-8、PC3、A549、MCF-7、L-02 和 HUVEC 細(xì)胞) 處理可抑制人類癌細(xì)胞的增殖。Isobavachalcone 抑制 PC3、A549、MCF-7、L-02 和 HUVEC 細(xì)胞生長，IC50 值分別為 15.06 μM、32.2 μM、28.29 μM、31.61 μM 和 31.3 μM[1]。
    Isobavachalcone (0-18 μM；6 小時；OVCAR-8 和 PC3 細(xì)胞) 處理導(dǎo)致 Akt 的 Ser-473 磷酸化和 GSK3b 磷酸化的濃度和時間依賴性下調(diào)[1]。
    Isobavachalcone (0-18 μM；72 小時；OVCAR-8 和 PC3 細(xì)胞) 處理通過 caspase 和 ROS 參與的線粒體途徑引起細(xì)胞凋亡[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Proliferation Assay[1]

    Cell Line: OVCAR-8, PC3, A549, MCF-7, L-02 and HUVEC cells
    Concentration: 6.0-48.0 μM
    Incubation Time: 72 hours
    Result: Inhibited the proliferation of human cancer cells.

    Western Blot Analysis[1]

    Cell Line: OVCAR-8 or PC3 cells
    Concentration: 0 μM, 6 μM, 12 μM, and 18 μM
    Incubation Time: 6 hours
    Result: A concentration-and time-dependent down-regulation of the Ser-473 phosphorylation of Akt. GSK3b phosphorylation was also inhibited in a concentration- and time-dependent manner.

    Apoptosis Analysis[1]

    Cell Line: OVCAR-8 cells and PC3 cells
    Concentration: 0 μM, 6 μM, 12 μM, and 18 μM
    Incubation Time: 72 hours
    Result: Led to dose dependent increase of apoptosis.
    體內(nèi)研究
    (In Vivo)

    Isobavachalcone (20 mg/kg；腹腔注射；持續(xù) 0.5-24 小時；雌性昆明小鼠) 處理導(dǎo)致血糖水平升高，在 1 小時內(nèi)達(dá)到最大值并維持至給藥后 4 小時[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Seven-week-old specific pathogen-free female Kunming mice (18-22 g)[1]
    Dosage: 20 mg/kg
    Administration: Intraperitoneal injection; for 0.5, 1, 2, 4, 6, 8, 12, 24 hours
    Result: Increased in blood glucose levels.
    分子量

    324.37

    Formula

    C20H20O4
    CAS 號
    性狀

    固體

    顏色

    Light yellow to yellow

    中文名稱

    補(bǔ)骨脂乙素；補(bǔ)骨酯乙素；異補(bǔ)骨脂查耳酮；異補(bǔ)骨脂查爾酮
    結(jié)構(gòu)分類
    初始來源
    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲存方式

    4°C, protect from light

    *In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

    溶解性數(shù)據(jù)
    細(xì)胞實(shí)驗(yàn)： 

    DMSO 中的溶解度 : 11 mg/mL (33.91 mM; 超聲加熱助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

    配制儲備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 3.0829 mL 15.4145 mL 30.8290 mL
    5 mM 0.6166 mL 3.0829 mL 6.1658 mL
    查看完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 1 year; -20°C, 6 months (protect from light)。-80°C儲存時，請在1年內(nèi)使用， -20°C儲存時，請在6個月內(nèi)使用。

    • 摩爾計算器

    • 稀釋計算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質(zhì)量
    =
    濃度
    ×
    體積
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    濃度 (start)

    C1

    ×
    體積 (start)

    V1

    =
    濃度 (final)

    C2

    ×
    體積 (final)

    V2

    動物溶解方案計算器
    請輸入動物實(shí)驗(yàn)的基本信息：

    給藥劑量

    mg/kg

    動物的平均體重

    g

    每只動物的給藥體積

    μL

    動物數(shù)量

    只
    由于實(shí)驗(yàn)過程有損耗，建議您多配一只動物的量
    計算結(jié)果
    工作液所需濃度 : mg/mL
    純度 & 產(chǎn)品資料

    純度: 99.01%

    參考文獻(xiàn)

    完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 1 year; -20°C, 6 months (protect from light)。-80°C儲存時，請在1年內(nèi)使用， -20°C儲存時，請在6個月內(nèi)使用。

    可選溶劑 濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.0829 mL 15.4145 mL 30.8290 mL 77.0725 mL
    5 mM 0.6166 mL 3.0829 mL 6.1658 mL 15.4145 mL
    10 mM 0.3083 mL 1.5414 mL 3.0829 mL 7.7072 mL
    15 mM 0.2055 mL 1.0276 mL 2.0553 mL 5.1382 mL
    20 mM 0.1541 mL 0.7707 mL 1.5414 mL 3.8536 mL
    25 mM 0.1233 mL 0.6166 mL 1.2332 mL 3.0829 mL
    30 mM 0.1028 mL 0.5138 mL 1.0276 mL 2.5691 mL
    Help & FAQs
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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    產(chǎn)品名稱：
    Isobavachalcone
    目錄號：
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