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  2. Metabolic Enzyme/Protease PI3K/Akt/mTOR Immunology/Inflammation NF-κB Apoptosis Epigenetics
  3. Endogenous Metabolite PI3K Akt HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species Caspase Interleukin Related MicroRNA
  4. Protectin D1

Protectin D1  (Synonyms: Neuroprotectin D1; NPD1)

目錄號(hào): HY-130413 純度: 99.10%
COA 產(chǎn)品使用指南 技術(shù)支持

Protectin D1，神經(jīng)細(xì)胞產(chǎn)生的神經(jīng)保護(hù)素 D1，是由二十二碳六烯酸產(chǎn)生的一個(gè)新的生物活性產(chǎn)品家族的成員。Protectin D1 還是一種專門的促分解介質(zhì)，在多種人類疾病模型中具有有效的體內(nèi)促分解作用。同時(shí)，Protectin D1 是一種 NALP3 炎性小體的抑制劑，能夠調(diào)節(jié) PI3K/AKT 和 HIF-1α 信號(hào)通路。Protectin D1 通過降低 ROS 水平，抑制 NALP3、ASC 和 Caspase-1 的表達(dá)，從而減少 IL-1β 和 IL-18 等促炎因子的釋放，發(fā)揮抗炎作用。此外，Protectin D1 通過上調(diào) miRNA-210，促進(jìn) PI3K/AKT 信號(hào)通路激活，發(fā)揮心臟保護(hù)作用。Protectin D1 有望用于心血管疾病和炎癥疾病的研究。

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Protectin D1 Chemical Structure

Protectin D1 Chemical Structure

CAS No. : 660430-03-5

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 μg (138.7 μM * 200 μL in ethanol) ￥2950
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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Protectin D1, a neuroprotectin D1 produced by neuronal cells, is a member of a newly discovered family of bioactive products derived from docosahexaenoic acid. Protectin D1 also serves as a specialized pro-resolving mediator, exhibiting effective in vivo pro-resolving activity in various human disease models. Additionally, Protectin D1 is an inhibitor of NALP3 inflammasomes and regulates the PI3K/AKT and HIF-1α signaling pathways. Protectin D1 exerts anti-inflammatory effects by reducing ROS levels, inhibiting the expression of NALP3, ASC, and Caspase-1, and consequently decreasing the release of pro-inflammatory cytokines IL-1β and IL-18. Furthermore, Protectin D1 enhances miRNA-210 expression, activates the PI3K/AKT signaling pathway, and exerts cardioprotective effects. Protectin D1 holds promise for research in cardiovascular diseases and inflammatory disorders[1][2].

IC50 & Target

Human Endogenous Metabolite

 

IL-1β

 

體外研究
(In Vitro)

Protectin D1 (1 μM, 24h) 通過上調(diào) miRNA-210 表達(dá)和激活 PI3K/AKT 信號(hào)通路，在新生大鼠心肌細(xì)胞中發(fā)揮保護(hù)作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR[3]

Cell Line: Primary neonatal rat cardiomyocytes
Concentration: 1 μM
Incubation Time: 24h
Result: Upregulated miRNA-210 expression.

Western Blot Analysis[3]

Cell Line: Primary neonatal rat cardiomyocytes
Concentration: 1 μM
Incubation Time: 24h
Result: Increased p-AKT and HIF-1α protein levels.
體內(nèi)研究
(In Vivo)

Protectin D1 (0.5 和 1 μM/kg，腹腔注射，一天一次共 3 天) 通過抑制氧化應(yīng)激和炎癥，改善 I/R 誘導(dǎo)的急性心肌梗死大鼠模型中的心臟功能，并減少梗死面積[3]。
Protectin D1 (0.08 mg/kg，腹腔注射，單次給藥) 通過降低 ROS 濃度來抑制 NALP3 炎性小體的激活，并減少促炎細(xì)胞因子水平，在 CLP 誘導(dǎo)的膿毒癥大鼠模型中發(fā)揮抗炎作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: I/R-induced acute myocardial infarction (AMI) rat model, male Sprague Dawley rats (8 weeks old)[3]
Dosage: 0.5 μM/kg, 1 μM/kg
Administration: Intraperitoneal injection (i.p.), once daily for 3 days before surgery
Result: Significantly reduced I/R-induced heart rate (HR), improved left ventricular ejection fraction (EF%) and fractional shortening (FS%), and reduced myocardial infarction area.
Animal Model: Cecal ligation and puncture (CLP)-induced sepsis Wistar rat model (8 weeks old, 200 g)[4]
Dosage: 0.08 mg/kg
Administration: Intraperitoneal injection (i.p.), single dose (12 hours before surgery)
Result: Significantly reduced ROS concentration in hepatocytes of CLP-induced rats, decreased NALP3, ASC, and Caspase-1 expression levels, and lowered serum IL-18 and IL-1β concentrations.
分子量

360.49

Formula

C22H32O4
CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

結(jié)構(gòu)分類
初始來源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Solution, -20°C, 2 years
純度 & 產(chǎn)品資料

純度: 99.10%

參考文獻(xiàn)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Protectin D1
目錄號(hào)：
HY-130413
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