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  2. Antibody-drug Conjugate/ADC Related PROTAC Anti-infection
  3. ADC Linker PROTAC Linkers Bacterial
  4. Propargyl-PEG8-acid

Propargyl-PEG8-acid 是一種 PROTAC 連接橋，屬于 PEG 類(lèi)。Propargyl-PEG8-acid 可用于合成一系列 PROTAC 分子。Propargyl-PEG8-acid 是一種可降解 (cleavable) 的 ADC 連接橋，用于抗體活性分子結(jié)合物 (ADCs) 的合成。這些 ADCs 可用于革蘭氏陰性細(xì)菌引起的細(xì)菌感染。Propargyl-PEG8-acid 是一種點(diǎn)擊化學(xué)試劑。它含有 Alkyne 基團(tuán)，可以和含有 Azide 基團(tuán)的分子發(fā)生銅催化的疊氮-炔環(huán)加成反應(yīng) (CuAAc)。

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Propargyl-PEG8-acid Chemical Structure

Propargyl-PEG8-acid Chemical Structure

CAS No. : 2055014-94-1

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規(guī)格 價(jià)格 是否有貨
25 mg ￥740
詢(xún)問(wèn)價(jià)格 & 貨期
50 mg ￥1180
詢(xún)問(wèn)價(jià)格 & 貨期
100 mg ￥2314
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250 mg ￥3544
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1 g 現(xiàn)貨 詢(xún)問(wèn)價(jià)格 & 貨期

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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Propargyl-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The ADCs can be used in bacterial infections caused by Gram-negative bacteria[1]. Propargyl-PEG8-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

Cleavable Linker

 

PEGs

 

體外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

436.49

Formula

C20H36O10
CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

純度 & 產(chǎn)品資料
參考文獻(xiàn)

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱(chēng)：
Propargyl-PEG8-acid
目錄號(hào)：
HY-130379
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