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  2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. m-PEG4-Br

m-PEG4-Br 是可降解 (cleavable) 的 ADC linker，用于合成曲妥珠單抗 (HY-P9907) 的抗體偶聯(lián)活性分子 (ADC)。m-PEG4-Br 被置于單甲基澳瑞他汀 E (MMAE) 有效載荷的遠(yuǎn)端，以產(chǎn)生具有改變的親水性，抗原結(jié)合和體外效能的 ADC。Tetraethylene glycol monotosylate 也可用作 PROTAC 的 Linker，可用于 PROTAC 的合成。

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m-PEG4-Br Chemical Structure

m-PEG4-Br Chemical Structure

CAS No. : 110429-45-3

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規(guī)格 價(jià)格 是否有貨
500 mg ￥120
詢問價(jià)格 & 貨期
1 g ￥239
詢問價(jià)格 & 貨期
5 g ￥972
詢問價(jià)格 & 貨期
10 g ￥1788
詢問價(jià)格 & 貨期
25 g ￥3455
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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab (HY-P9907). m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency[1]. m-PEG4-Br also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.

IC50 & Target[1]

Cleavable Linker

 

PEGs

 

體外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

271.15

Formula

C9H19BrO4
CAS 號(hào)
性狀

液體（密度：1.256 g/cm3）

顏色

Colorless to light yellow

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料
參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
m-PEG4-Br
目錄號(hào)：
HY-130161
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