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  2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Withanone

Withanone 是來(lái)自 Withania somnifera 根的活性成分，在減輕認(rèn)知功能障礙方面具有多功能的神經(jīng)保護(hù)作用。在神經(jīng)元樣細(xì)胞中，Withanone 可以抑制 NMDA 誘導(dǎo)的興奮性毒性。

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Withanone Chemical Structure

Withanone Chemical Structure

CAS No. : 27570-38-3

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1 mg ￥5714
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Other Forms of Withanone:

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

查看 iGluR 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Withanone is an active constituent from Withania somnifera roots with multifunctional neuroprotective effect in alleviating cognitive dysfunction. Withanone affords protection against N-methyl-D-aspartate (NMDA)-induced excitotoxicity in Neuron-like cells[1][2].

IC50 & Target

NMDA Receptor

 

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 10 μM
Compound: 11
Cytotoxicity against human A549 cells after 72 hrs by SRB assay
Cytotoxicity against human A549 cells after 72 hrs by SRB assay
[PMID: 30776236]
HCT-15 IC50
5.9 μM
Compound: 11
Cytotoxicity against human HCT15 cells after 72 hrs by SRB assay
Cytotoxicity against human HCT15 cells after 72 hrs by SRB assay
[PMID: 30776236]
SK-MEL-2 IC50
6.1 μM
Compound: 11
Cytotoxicity against human SK-MEL-2 cells after 72 hrs by SRB assay
Cytotoxicity against human SK-MEL-2 cells after 72 hrs by SRB assay
[PMID: 30776236]
SK-OV-3 IC50
> 10 μM
Compound: 11
Cytotoxicity against human SKOV3 cells after 72 hrs by SRB assay
Cytotoxicity against human SKOV3 cells after 72 hrs by SRB assay
[PMID: 30776236]
體外研究
(In Vitro)

Withanone (5-20 μM; Neuro2a cells) treatment significantly reverses the cell death induced by NMDA in N2a cells[1].
Withanone (5-20 μM; Neuro2a cells) treatment significantly normalizes Bax and Bcl-2 levels[1].
Attenuation of NMDA-induced intracellular calcium releases by Withanone in N2a cells[1].
Withanone attenuates NMDA-induced Reactive Oxygen Species generation in N2a cells and induces attenuation of mitochondrial membrane motential loss[1].
Withanone treatment down-regulates the expression of cytochrome c[1].
Withanone treatment decteases the Malondialdehyde levels in NMDA-induced excitotoxicity[1].
Withanone shows promise in Alzheimer's disease (AD) treatment because of cognitive benefits and more importantly, mechanisms of action with respect to the fundamental pathophysiology of the disease, not limited to the inhibition of AChE, but also include the modification of Aβ processing, protection against oxidative stress and anti-inflammatory effects. Withanone (24 hours) treatment shows significant protective effect against amyloid β (Aβ) toxicity in Aβ induced toxicity in PC-12 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Neuro2a (N2a) cells
Concentration: 5 μM, 10 μM, 20 μM
Incubation Time:
Result: Attenuated NMDA-Induced cell death in N2a cells.

Western Blot Analysis[1]

Cell Line: Neuro2a (N2a) cells
Concentration: 5 μM, 10 μM, 20 μM
Incubation Time:
Result: Normalized NMDA-induced alterations in Bax and Bcl-2.
體內(nèi)研究
(In Vivo)

Withanone (5-20 mg/kg; oral administration; daily; for 21 days; male Wistar rats) treatment shows significant improvement in the cognitive skill by inhibiting amyloid β-42 and attenuates the elevated levels of pro-inflammatory cytokines like TNF α, IL-1β, IL-6, MCP-1, Nitric oxide, lipid peroxidation and both β- and γ- secretase enzymatic activity. Administration of Withanone also significantly reverses the decline in acetyl choline and Glutathione (GSH) activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (20-24 weeks; 320-360 g) received ICV injection of STZ[1]
Dosage: 5 mg/kg, 10 mg/kg and 20 mg/kg
Administration: Oral administration; daily; for 21 days
Result: Showed significant improvement in the cognitive skill by inhibiting amyloid β-42 and attenuated the elevated levels of pro-inflammatory cytokines like TNF alpha, IL-1β, IL-6, MCP-1, Nitric oxide, lipid peroxidation and both β- and γ- secretase enzymatic activity. Also significantly reversed the decline in acetyl choline and Glutathione (GSH) activity.
分子量

470.60

Formula

C28H38O6
CAS 號(hào)
性狀

固體

顏色

White to off-white

結(jié)構(gòu)分類
初始來(lái)源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料
參考文獻(xiàn)

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  • 稀釋計(jì)算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Withanone
目錄號(hào)：
HY-129692
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